Báo cáo y học: "Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b" ppt

... Biology and Medical Modelling Open Access Research Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b Trevor G Marshall* 1 , Robert E Lee 2 and ... from the 1-hydroxyl oxy- gen to the aminoacetal of ARG274 and the hydroxyl of SER237, and another pair from the ligand's O3 oxygen to SER278 and T...

Ngày tải lên: 13/08/2014, 23:20

... study polymorphic effects on the synthesis of IL-6 have shown that its transcription and synthesis are affected by the allelic varia- tions within the gene, although the mechanism and level of the contribution ... expression and plasma levels of IL-6 [17,30], and the same polymorphism has recently been directly linked to hip OA, because the CC genotype was significantl...

Ngày tải lên: 09/08/2014, 10:23

... monocytes and AM from healthy young and elderly non-smokers were observed. The mechanisms of the smoking induced alteration of pulmonary immune functions are poorly understood. On the one hand ... situ hybridization and conceived of the study. TT carried out cell culture experiments and was involved in drafting the manuscript. PZ, KD and BS con- ducted the clinical par...

Ngày tải lên: 12/08/2014, 18:21

... gathered in primary care along with all the cases, and the second made with the controls gathered in the hospitals and the same cases, the first showed significant values in the three pre- dictors ... of the predictors and because it was “coherent” with the clinical and biological reality. The age and CA 19.9 were “predisposing” for the condition with OR’s...

Ngày tải lên: 03/11/2012, 11:34

... to assess the reproducibility of the histology scoring systems by independent observers [25]. Results Graft morphology and histology scores (Table 4) The thickness of the cartilage in the patient ... Certainly in the present study there was no staining with the anti- body 7-D-4 in totally fibrocartilaginous samples (either the ACI biopsy specimens or the meniscus). MRI is...

Ngày tải lên: 09/08/2014, 01:21

... for autoimmune myositis Classification Abbreviation Definition/description Original Bohan and Peter classification PM Primary polymyositis DM Primary dermatomyositis CTM Myositis with another connective ... characterized by involvement of the cellular and humoral immune systems in skeletal muscle pathology, immunogenetic modulation, response to immunotherapies, and the presence of...

Ngày tải lên: 09/08/2014, 10:20

... inhibit the GSK-3/NF-κB pathway and reduce inflammatory markers associated with bone and cartilage degradation Veera Reddy Konda*, Anuradha Desai, Gary Darland, Jeffrey S Bland and Matthew L ... inflammatory genes and proteins. Alternatively, independent of IKK acti- vation, phosphorylation of NF-κB p65 at serine 468 by glycogen synthase kinase (GSK)-3β also activates the NF- κ...

Ngày tải lên: 11/08/2014, 08:22

... (59% of the consumers, 74% carers, 33% of the clinicians). The median age category was 40-49 years f or the consumers, 50-59 years for the carers and 50-59 years for the clinicians. Out of the 27 ... depending on the stage of problem drug use. The guidelines were developed specifically for Western, English speaking countries and may have limited applic- ability to othe...

Ngày tải lên: 11/08/2014, 16:22

... interval may be non- diagnostic. Elevated creatine kinase and aldolase of a non-cardiac cause and endoscopic findings of ischaemic ulceration and difficulty in negotiating the pylorus may raise the ... and finally (3) computed tomography. Conclusion: Non-specific and misleading symptoms and signs may delay the diagnosis of intermittent, subacute volvulus. Imaging studi...

Ngày tải lên: 11/08/2014, 19:21

... MMP-13 synthesis) and anabolism (type II collagen synthesis) are high. It is unclear whether elevated catabolism and enhanced anabolism is achieved by the same cells or by diff erent chondrocyte ... is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis. J Clin Invest 1996, 97:2011-2019. 7. Inada M, Wang Y, Byrne MH, Rahman MU, Miyau...

Ngày tải lên: 12/08/2014, 11:22