Báo cáo y học: "Comment on and reply to "Analysis of variation of amplitudes in cell cycle gene expression" by Liu, Gaido and Wolfinger: On the analysis of gene expression during the normal, eukaryotic, cell cycle" docx

... cycle gene expression& quot; by Liu, Gaido and Wolfinger: On the analysis of gene expression during the normal, eukaryotic, cell cycle Stephen Cooper* Address: Department of Microbiology and Immunology, ... Wolfinger on gene expression during the division cycle of HeLa cells using the data of Whitfield et al. are discussed in orde...

Ngày tải lên: 13/08/2014, 23:20

... binding element, and the mutated bases are indicated by italic type). Western blot analysis The MREa-binding proteins purified from HepG2 cells by the avidin–biotin method and lysates (30 lg) of ... of the Ku-80 subunit and the truncated Ku-80 mutant on WD gene expression To examine the effects of the Ku protein on the regulation of WD gene expr...

Ngày tải lên: 17/03/2014, 23:20

... words: Cystatin C, Creatinine, Digoxin, Serum concentration, Heart failure, Renal clearance 1. Introduction Cystatin C (Cys-C) is a non-glycosylated cationic protein of 13.3 kDa, belonging to the ... concentration to maximize the therapeutic effects and minimize toxicities [16-19]. Since digoxin is mainly eliminated via the kidneys, the renal function of the patient...

Ngày tải lên: 31/10/2012, 17:08

... in the hydroxylases. The mutation of these residues in the desaturases to the corresponding hydroxylase residues resulted in the conversion of desaturase activity to hydroxy- lase activity. The ... catalyzes the condensation of a 16:1 moiety with malonyl-ACP. The crystal structure of KAS II alone and with the mycotoxin inhibitor, cerulenin, revealed that...

Ngày tải lên: 21/02/2014, 15:20

... Krzysztof Blusztajn 1,2 and Brygida Berse 1 1 Department of Pathology and Laboratory Medicine and 2 Department of Psychiatry, Boston University School of Medicine; Boston, MA, USA The expression ... regulatory proteins [13]. Speci®city of MAPK effects in different cell types and in response to different stimuli is achieved by the action of scaffolding protein...

Ngày tải lên: 31/03/2014, 21:21

... as the location and magnitude of bind- ing sites. Our work builds on many of the innovations introduced by Valouev and colleagues [4] to the analysis of ChIP-seq data in their method QuEST, including ... established by mobility shift assays [16], and the relative contribu- tions of the two sites to the induction of acr by DosR under hypoxia correspo...

Ngày tải lên: 09/08/2014, 20:21

... and the interpretation of the data, and revised the manuscript for important intellectual content. PES conceived of the study, contributed to the interpretation of the data, and revised the manuscript ... intellectual content. JHR conceived of the study, contributed to its design and the interpretation of the data, and revised the manuscript for i...

Ngày tải lên: 13/08/2014, 11:23

... implications of amplitudes of cycling genes, referred to as the maximum expression level in one cycle, have not been explored in any previous microarray study of cell cycle or circadian cycle gene expression ... measures of cell culture synchrony, and investigation of the impacts of cell culture with various degrees of synchrony on expression...

Ngày tải lên: 13/08/2014, 23:20

... transthyretin expression after injury. These find- ings provide new insights into the mechanism of the negative transcriptional regulation of the transthyretin gene after injury caused by a decrease in the ... transcription (Fig. 2A), the reduction in binding ability, either by a post-translational alteration in binding efficiency or a change in HNF availability, c...

Ngày tải lên: 23/03/2014, 03:20

... University of Thessaloniki, Thessaloniki, Greece Correspondence to: Dr. Christos P. Panteliadis, Professor of Paediatric Neurology, Aristotle University of Thessaloniki, Vas. Olgas 97, Thessaloniki, ... that the factors retaining their prognostic value were: family history of FS and low age at onset. The rest factors lost their power for the prognosis of multiple recur...

Ngày tải lên: 08/08/2014, 16:23