Báo cáo y học: "Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer" potx

... MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer L Michel Espinoza-Fonseca* Address: Department of Biochemistry, Molecular Biology, and Biophysics, ... observed by these compounds would compen- sate their therapeutic deficiencies because of the dynamic nature of the targets involved and the observed pro...

Ngày tải lên: 13/08/2014, 23:20

... indicator development. The final approach to composite indicator development is the result of a com- bination of approaches described by Profit and collea- gues with methods developed by the European Commission ... indicato r development that require empirical research. These include paucity of interactions with the healthc are system, paucity of criti- cal health out...

Ngày tải lên: 11/08/2014, 05:21

... Values of k cat and K 0 m are independent of the enzyme assay. Biosynthesis of N -amidino-2-hydroxypyrrolidine N-Amidino-2-hydroxypyrrolidine was synthesized as fol- lows. Twenty micrograms of P. ... oxidation by P. sativum copper amine oxidase may represent a new biocatalytic route for the synthesis of N-amidino-2-hydroxypyrrolidine, possibly representing a lead compound fo...

Ngày tải lên: 17/03/2014, 23:20

... in the USA [1]. The cause of rhabdomyolysis is often multifacto- rial [2], and approximately 8–20% of such patients develop myoglobinuric ARF [3]. The myoglobin released during rhab- domyolysis ... on myoglobin clearance or the cutoff size of the pores of the membrane used. A potential adverse effect of SHF (high cutoff point) hemofil- tration is the loss of serum al...

Ngày tải lên: 12/08/2014, 20:21

... model of ventilator-induced lung injury. This study is important because it is the first to explore the effects of dopamine on survival, albeit short term. The delivery of dopamine into the airspaces ... but have not yet been shown to reduce mortality [3]. Despite the incorporation of these approaches into clinical practice, the incidence of VILI and mortality in patient...

Ngày tải lên: 13/08/2014, 10:20

... such a way so that there is synergistic effect of both the domains, activa- tion of specific T cell help and neutralization of wild type isolates. The study validates the superiority of hybrid pep- tide ... the activation of macrophages and natural killer cell antibody dependent cellular cytotoxicity whereas IgG1 has very limited activity. In the present study the determ...

Ngày tải lên: 11/08/2014, 10:23

... and the majority indicated that their grief-related loss was due to violent death (70%). Grief was predicted mainly by time since the loss, by the violent natur e of the loss, the severity of symptoms ... particularly relevant in the context of violence. Results of the present study demonstrate that the severity of PTSD is associated with the severity of PGD....

Ngày tải lên: 11/08/2014, 16:22

... of the glyoxylate cycle in yeast grown on carbon sources other t han fatty acids. The only other key enzyme unique to the glyoxylate cycle, Icl1p, is also extra-peroxisomal [4], as are the other enzymes ... dehydrogenase activity speci®cally involved in the glyoxylate cycle is attributed to the cytosolic isoform Mdh2p [7]. The suggestion of an extra-peroxisomal location for...

Ngày tải lên: 22/02/2014, 04:20

... binding of Ca 21 by assuming the presence of four steps of sequential and ordered binding. To identify the site of the EF-hand corresponding to the nth binding of Ca 21 , we measured the affinity for ... order to determine the affinity for Ca 21 and the cooperativity of Ca 21 -binding to p26olf, we next analyzed the stoichiometry of Ca 21 -binding to p26olf by...

Ngày tải lên: 24/03/2014, 04:21

... constructed with the VMD software [36]. Fig. 6. NMR structure of the amphipathic domain of YopD illustrating the hydrophobic and hydrophilic sidedness of the peptide. Thesidechains are displayed for residues ... localized to the host cell cytosol [10]. In addition, we and others observed that a yopD null mutant is constitutively induced for synthesis of Yops in vitro, while...

Ngày tải lên: 31/03/2014, 21:21