Báo cáo y học: " Possible Cis-acting signal that could be involved in the localization of different mRNAs in neuronal axons" potx
Báo cáo y học: " Possible Cis-acting signal that could be involved in the localization of different mRNAs in neuronal axons" potx
... secondary structure of 3'-UTR of cofilin mRNA. The arrow indicates the U-rich signal sequence that could be involved in the localization of the messenger. Signal Sequence Theoretical Biology ... of U-rich mRNAs that could be trans- ported to the axon. The results show that the secondary structures of synuclein and cofilin mRNAs are very...
Ngày tải lên: 13/08/2014, 23:20
Báo cáo y học: "Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability" pptx
... in models might be the cause of difference in the results. In the present study, the abnormal stress on cartilage tissues induced by joint instability was the main cause of degeneration. The ... point to an important role in inflammation[9]. Pro-inflammatory signaling mediators such as IL-1 and TNF-α induce the synthesis of PGE2 by promoting the expression...
Ngày tải lên: 12/08/2014, 18:20
Báo cáo y học: " Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus" potx
... overlapping the active site of the enzyme, suggesting that this site represents the binding site for Env. Analysis of synonymous and non-synonymous nucleotide substitutions in the coding sequences of ... affecting the receptor activity of human Hyal2 [5]. To determine if portions of the amino terminus beyond the signal sequence could be deleted without affect...
Ngày tải lên: 13/08/2014, 09:21
Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"
... that bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously in a specific orientation, in which Tyr-627 binds to the N-SH2 domain and Tyr-659 binds to the ... biologically plausible observation would stimulate interest in the study of the molecular mechanisms of action of this polymorphism. Because these results were based on...
Ngày tải lên: 31/10/2012, 15:37
Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc
... As both the E a of inactivation and the temperature at which the enzyme starts inactivating at a measurable rate increase from the apoenzyme to the Mn 2þ -containing enzyme, loss of the metal cofactor ... cofactor could be the limiting step in BLXI inactivation. Higher E a values of inactivation for the Co 2þ – enzyme and the Mn 2þ –enzyme reflect the higher the...
Ngày tải lên: 22/02/2014, 07:20
Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx
... machinery, the common feature being that they cause dephosphorylation of 4E-BP1 and thus inhibition of eIF4E. In addition to providing further information on the regulation of a number of components involved ... consider their effects on protein synthesis when studying the effects of these stress conditions on cell physiology. Other agents that inhibit protein synthesi...
Ngày tải lên: 18/03/2014, 01:20
Báo cáo y học: "Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action" pps
... and bradykinin synthesis, since HA inhibited their synthesis in a MW-dependent manner [16]. Further, HA has been shown to induce analgesia in a bradykinin-induced model of joint pain in rats ... may be involved in cartilage catabolism by inhibiting the synthesis of colla- gen and PG, enhancing MMP activity, reducing the synthe- sis of an IL-1 receptor antagonist by chond...
Ngày tải lên: 09/08/2014, 01:21
Báo cáo y học: "α Anti-α-fodrin antibodies do not add much to the diagnosis of Sjögren’s syndrome" pot
... autoimmune exocrinopathy of unknown origin. Therefore the diagnosis of SjS, in the absence of a gold standard, is based on cri- teria containing a number of subjective and objective signs and symptoms. In the ... present in SjS sera and that the majority of these antibodies are of the IgG and IgA class, but that their frequency in SjS sera is not higher than...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Patients, their doctors, nonsteroidal anti-inflammatory drugs and the perception of risk" docx
... decision-making process leading to the use of the specific therapy remains daunting. The issue of the relative risk for a therapeutic in the context of its relative benefit should nonetheless continue ... probably the most misunderstood component in determining therapeutic intervention; however, it is probably the most relevant issue to consider in the context of...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "A second-generation autologous chondrocyte implantation approach to the treatment of focal articular cartilage defects" ppsx
... application may be impossible in certain areas of the joint because of anatomic factors, and the fixation of the periosteal flap or collagen sheets covering the chondrocyte suspension may Commentary A ... It is noteworthy that the histologic analysis was derived from 18% of the patients who under- went second-look arthroscopy as a result of grinding, catching, pain...
Ngày tải lên: 09/08/2014, 10:21