Báo cáo y học: "Location of DNA damage by charge exchanging repair enzymes: effects of cooperativity on location time" doc

... [4Fe-4S] 2+ -containing T / τ t N N t location MutY MutY location = () .4 tT T location MutY MutY ≈ () τ .5 T / τ vk/ t location MutY t location MutY t location MutY tT vT v k location MutY MutY where ... all the repair enzymes, the location time only varies as N -1/2 and not as 1/N. Conclusion: The revolutionary hypothesis that DNA repair enzymes use charge exchange...

Ngày tải lên: 13/08/2014, 22:22

... actions (especially at higher doses) and the genomic actions transrepression and transactivation are not fully synonymous with inflammatory and immunosuppressive activity and with adverse effects, ... GR, Avery W, Finelli AL, Farwell M, Fraser CC, Borisy AA: Selective amplification of glucocorticoid anti- inflammatory activity through synergistic multi-target action of a combination drug...

Ngày tải lên: 09/08/2014, 01:22

... characterized by both raining season of heavy rainfall with 90% humi dity and dry season of few rains with drought. The rainfall is about 2,700-4,700 mm per year. Gongshan is anationallevelpovertycountyaccordingtostatecri- teria, ... villages, Gongshan County [9]. The livelihood of Nu communities is typically agro-pastoralist and dependent on animal production. There are a great var...

Ngày tải lên: 10/08/2014, 09:21

... acquisition of data. NP: Has made substantial contributions to acquisition of data. SZ: Has made substantial contributions to acquisition of data. EA: Has made substantial contributions to conception ... Greece. Authors’ contributions PD: Has made substantial contributions to conception and design, acquisition of data and analysis and interpretation of data. Also, has given final ap...

Ngày tải lên: 10/08/2014, 09:22

... activity on the 3rd postop- erative day, which contrasts the regenerative peak observed in rats after only 24 h post liver injury. To test our hypothesis that liver regeneration by compensatory hyperplasia ... telomerase activity in regenerative liver nodules. This conclusion is supported by the significant correlation of telomerase activity to the number of mitotic hepatocytes in o...

Ngày tải lên: 13/08/2014, 13:20

... test. Results Optimization of the PCR conditions The optimum concentration of MgCl 2 for PCR amplifica- tion of mtDNA was determined by analyzing PCR reac- tions containing various concentrations (2.0, 3.0, ... infiltration of new inflammatory cells, the death of resident cells, and the continuous secretion of DNA adducts, all of which contribute to the inflammatory outcome....

Ngày tải lên: 09/08/2014, 01:23

... regu- latory and full length of exon 1 regions of the HLA-G gene. Nevertheless, 98–99% of the same regions in our study matched with the previously published sequence of that region by Geraghty et ... perinatal transmis- sion of HIV-1 [9]. Although, the mutation in exon 2 region was considered as a silent mutation, a study by Duan et al., [17] has demonstrated that a silent muta...

Ngày tải lên: 10/08/2014, 05:20

... enhanced frequency of spontaneous mutations, recombinations and DNA fragmentation [35-39]. The BER process is one of the cellular DNA repair mecha- nisms responsible for correcting most of common forms of DNA ... The (cytosine-5)-methyl- transferase, is in charge of the conversion of cytosines within CpG islets to 5-methylcytosines. In mammalian cells, 5-methylcytosines...

Ngày tải lên: 13/08/2014, 05:20

... of errors in the VSG interaction, additional variance analyses were performed with combinations of 2 slides: (i) by omitting slide 1 (S1; containing a self-hybridization) the VSG interaction ... relatively large contribution of the total variance to specific sources of errors (67 %) because of the efficient design of the validation experiment described here. Since the contri...

Ngày tải lên: 14/08/2014, 14:21

... Genome Biology 2005, 6:404 Correction Correction: A DNA microarray survey of gene expression in normal human tissues Radha Shyamsundar* † , Young H Kim*, John P Higgins*, Kelli Montgomery*, Michelle ... Ltd Received: 22 July 2005 Accepted: 29 July 2005 We wish to report two corrections to our study [1], neither of which alters the interpretation of the data or the conclu- sions drawn...

Ngày tải lên: 14/08/2014, 14:22