Báo cáo y học: "A steady state analysis indicates that negative feedback regulation of PTP1B by Akt elicits bistability in insulin-stimulated GLUT4 translocation" potx

... purposes) Theoretical Biology and Medical Modelling Open Access Research A steady state analysis indicates that negative feedback regulation of PTP1B by Akt elicits bistability in insulin-stimulated GLUT4 translocation Lopamudra ... providing insights into possible pathological conditions. Conclusion: A steady state analysis indicates that negati...

Ngày tải lên: 13/08/2014, 22:22

... effect of TM on thrombin inhibition by ATIII and protein C inhibitor, these findings indicate that TM considerably reduces the rate of thrombin inhibition by PAI-1. The poor rate of inhibition of ... TP disappears in time at steady state after the rapid initial increase. The pronounced biphasic character of the inhibi- tion profiles in Fig. 1A–C is explained by the pre...

Ngày tải lên: 23/03/2014, 17:21

... Pellegrin JL, Viallard JF: Steady- state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical  ares: an observational cohort study. Arthritis ... Ltd Correction: Steady- state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical  ares: anobservational cohort study Sa...

Ngày tải lên: 12/08/2014, 15:22

... events occurring in single cells, even complex interactions in path- ways, may reveal themselves through the analysis of samples of mesoscopic size. In many ways, this situation is analogous to one in ... http://genomebiology.com/2006/7/12/R119 Genome Biology 2006, 7:R119 developed a microfluidic-based assay to observe proteins being produced in real-time inside a living cell....

Ngày tải lên: 14/08/2014, 17:22

... availability of the regulatory proteintointeractwithDNAmaydependonitsactivity, which is generally established through a protein–protein interaction [6,7]. It should be noted that the two interacting molecules ... uniquely determined by (a) resources available in terms of total concentrations; (b) in v ivo mechanisms reflected by the sequence of interactions; (c) parameters quan...

Ngày tải lên: 07/03/2014, 16:20

... past year? YES NO If yes, how many times? Have you been in a physical fight in the past year? YES NO If yes, how many times? Have you been arrested in the past year? YES NO If yes, how many times? Do ... thoughts of playing video games? 11. How often do you find yourself anticipating when you will play video games again? 12. How often do you fear that life without video games woul...

Ngày tải lên: 08/08/2014, 21:20

... induced reduc- tion of BP [23]. Study recruitment was only 11% of that for which it was powered, for a variety of reasons including the inherent difficulty in recruiting patients within the allowed ... with the highest probability of being cost-effective at varying threshol ds of willingness to pay for a unit of outcome, and is a means of expressing uncertainty around point...

Ngày tải lên: 13/08/2014, 11:22

... Forest University School of Medicine, Winston-Salem, NC, USA, 2 Laboratory of Clinical Epidemiology, INRCA Geriatric Department, Florence, Italy and 3 Department of Internal Medicine, Wake Forest ... drug therapy offers greater economic benefits for controlling isolated systolic hypertension in the elderly than other antihyper- tensive drug treatments. Using a decision analysis m...

Ngày tải lên: 13/08/2014, 13:20

... function of Sirtuins as, in yeast, they are known to play roles in telomeric silencing Table 3 Genes differentially regulated in cdc13-1 strains that suppress temperature sensitivity of cdc13-1 Common ... Function CPA2 YJR109C Large subunit of carbamoyl phosphate synthetase TPS1 YBR126C Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex YIL055C Hypothetical...

Ngày tải lên: 14/08/2014, 21:20

... an enzyme involved in the initial steps of the metabolism of 4-amino-3-hydroxybenzoic acid. 4-Amino-3-hydroxybenzoate 2,3-dioxygenase contained 1.9 mol Fe 2+ per mol of enzyme. Addition of Fe 2+ increased ... dioxygenase; 4-amino-3-hydroxybenzoate 2,3-dioxygenase. Dioxygenases catalyzing the fission of benzene rings are key enzymes in the microbial metabolic pathways of aromati...

Ngày tải lên: 21/02/2014, 01:21