Báo cáo y học: "Early norepinephrine resuscitation of lifethreatening hypotensive septic shock: it can do the job, but at what cost" pptx
Báo cáo y học: " Early phase resolution of mucosal eosinophilic inflammation in allergic rhinitis" ppt
... and relativelyuncomplicated. Animal data suggest that corticosteroidtreatment does not prevent but may permit the egression of eosinophils into the airway lumen [8]. In the presentstudy, it was ... toplacebo treatment (Fig. 2A). The epithelial eosinophiliawas not significantly reduced by budesonide treatment(Fig. 2B) but the eosinophilia beneath the epithelium wassignificantly reduced (Fig. ... neither in the placebo-group nor in the steroid-treated group.Immunostaining of CCL5 and CCL11In placebo-treated individuals, the intensity of CCL5immunoreactivity was pronounced in the epithelium,including...
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Báo cáo y học: "Early down-regulation of the pro-inflammatory potential of monocytes is correlated to organ dysfunction in patients after severe multiple injury: a cohort study" pptx
... severely ill patients do not allow pre-cise determinations of cytokine synthesis and secretion invivo. In addition, the interpretation of cytokine data is compli-cated by the fact that some mediators, ... overallinflammatory reaction of the immune system. However, there islittle known about the functional alterations of monocytes in the early posttraumatic phase, characterized by the battle of the individual ... as amonitoring device at the bedside. It seems reasonable to assume that the intensity of monocytictemporal paralysis, that is, the diminished capacity to releaseproinflammatory cytokines...
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Báo cáo y học: " Early fluid resuscitation with hyperoncotic hydroxyethyl starch 200/0.5 (10%) in severe burn injury" ppsx
... statistical situation was the CLARICOR(effect of clarithromycin on mortality and morbidity inpatients with ischemic heart disease) study, in which the analysis of clarithromycin in patients with stable ... debate aboutfluid resuscitation, the role of crystalloids and colloids in the critically ill patient, the safety of HES, and even about the design of the VISEP study [2,3]. In this context and ... in septic patients our studyalso showed that the application of HES 200/0.5 (10%) ina population of severely burned patients may be associ-ated with fatal outcome in comparison to traditional...
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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... study was to evaluate the inhibitory effect of some thioglycosides synthesized in our laboratory on human hSGLT1 and hSGLT2 –as a potential therapeutic alternative for the control of hyperglycemia, ... a substrate, it is possible that other glucoside derivates could also inhibit the activity of SGLT. The role of glucose analogues on SGLT inhibition has been well demonstrated in vitro [19, ... to date [16]. It in-hibits the activity of SGLT in the kidney leading to glycosuria [17]. Its clinical application; however, is restricted due to hydrolysis by β-glucosidases in the intestine...
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Báo cáo y học: "A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome" ppsx
... (Figure 5). Cardiotoxicity and early death rate of CAG The toxicity of CAG in all reports was generally mild. Cardiotoxicity data were reported in 33 studies with 953 patients, and ED was reported ... Remarkably, the CR rate of CAG was significantly higher than those of non-CAG regimens (odds ratio 2.43). CAG regimen was well tolerated, with cardiotoxicity in 2.3% and early death in 5.2% of the ... CR rate. Alternatively, it may be that the first-line induction therapy was substandard in these patients from diverse institutions with different supportive care standards. Therefore, the...
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Báo cáo y học: "Monostotic fibrous dysplasia of a lumbar vertebral body with secondary aneurysmal bone cyst formation: a case report" pptx
... Rapid growth of the secondary ABC withdestruction of the intramedullary and juxtacortical struc-tures of the vertebral body, in combination with the dysplastic bone, may lead to pathological ... vertebrectomy of the L4 vertebralbody with curettage of the entire cyst wall. Stabilizationand reconstruction of the defect was performed with the use of an anterior stackable cage filled with tricalciumphosphate ... histologicalconfirmation.A pathological fracture of the lesion probably causes the initiating symptoms in patients with MFD with super-imposed secondary ABC. Our case also did not have anypreceding signs of low...
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Báo cáo y học: "Increase in markers of airway inflammation after ozone exposure can be observed also in stable treated " ppsx
... evaluations and sputum induction. We also thank Dr. MassimoCorradi from the University of Parma (Italy) for performing the genotypiccharacterization of the patients. The study was supported by ... cohort study. Lancet 2002, 359:386-391.3. Committe of the Environmental and Occupational Health Assembly of the American Toracic Society: Health effect of outdoor air pollution. State of the art. ... showing that the deleted form of Glutathione-S-Transferase M1 enzyme (GSTM1 null),resulting in a complete lack of its enzymatic function,associated with the pro187 form of NAD(P)H:quinoneoxidoreductase...
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Báo cáo y học: "Efficacy and safety of tiotropium in COPD patients in primary care – the SPiRiva Usual CarE (SPRUCE) study" ppsx
... device.Patients were excluded if they had any other significantmedical condition that might interfere with the study orpreclude their use of study medication, such as knownhypersensitivity to ... popu-lations seemingly recruited from secondary care centres[11-14]. The majority of patients with COPD receive treat-ment mainly from primary care; hence, it is probable thatmany patients ... Viatris.Authors' contributionsAll authors participated in the design of the study, inter-pretation of data and the drafting and approval of the final manuscript. AL performed the statistical...
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Báo cáo y học: "Continuous noninvasive monitoring of barbiturate coma in critically ill children using the Bispectral™ index monitor" doc
... in the design of the study and in the interpretation of the data. JHB participatedin the interpretation of the data and helped to draft the manuscript. DT conceived the study and participated ... Underthese conditions, the additional advantages of continuous full-channel EEG probably do not outweigh the practical barriersto this modality. Of course, for objective evaluation of the safety ... Second, in the first four includedpatients, the software available at that time did not allowrecording and exportation of the raw EEG data. Therefore, inthese patients we matched patterns in...
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