... enhanced interleukin-6 type pleiotropic activities. Eur.Cyt. Netw. 8, 359–365.36. Fukada, T., Hibi, M., Yamanaka, Y. , Takahashi Tezuka, M.,Fujitani, Y. , Yamaguchi, T., Nakajima, K. & Hirano, ... reflected by the activationpattern of STAT3 and MAP kinases, mainly p42, wereidentical for BAF/3 cells stimulated with Hyper-IL-6,Hyper-CNTF, and LIF.Analysis of the biological activity of Hyper-CNTF ... concentrations) alone were able to activate theMAPK pathway. MAP kinases and STAT3 are rapidlyactivated within 10 min in response to Hyper-CNTF, thephase of activation lasting for at least 30 min...