Báo cáo y học: "Protective role of statins against ventilator-induced lung injury" doc
Báo cáo y học: "The role of statins as potential targets for bone formation" pptx
... characteristic of
established osteoporosis.
Chemical nature of statins
Statins are specific, competitive inhibitors of the 3-
hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reduc-
tase enzyme. These ... organization of bone
and other mineralized tissues and the mechanism of calcifi-
cation. In: Handbook of physiology, endocrinology, parathyroid
gland. Edited by Aubarch GD. Washin...
Báo cáo y học: " Protective role of vascular endothelial growth factor in endotoxin-induced acute lung injury in mice" potx
...
of Medicine, Tokyo, Japan,
3
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, Tokyo,
Japan and
4
Department of Emergency and Critical Care ... the lung induces pulmonary edema with
increased lung vascular permeability, the role of VEGF in the development of acute lung injury remains to be determined.
Methods: To ev...
Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc
... inhibi-
tion of COX-2 is really significant to the quality or timeli-
ness of the healing. Indeed, the study by Zhang et al. [12]
showed that restoration of PGE
2
levels immediately
rescues the effects of ... activity of a glucocorticoid-regulated inflammatory
cyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892.
7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inf...
Báo cáo y học: " The role of pneumolysin in mediating lung damage in a lethal pneumococcal pneumonia murine model" pot
... number of colony-forming units (CFU).
PLY detection by ELISA
Quantification of PLY was performed by ultrasensitive
enzyme-linked immunoassay (ELISA) as described previ-
ously [27]. Briefly, Triton ... decreased
infiltration of leukocytes in foci of infection [28]. Exagger-
ated inflammatory responses mediated by PLY may favor
microbial survival by promoting premature, auto-oxida-
tive...
Báo cáo y học: "The role of unintegrated DNA in HIV infection" docx
... immunodefi-
ciency virus (FIV) that does not encode nef,butdoes
contain rev [184].
Preintegration latency may contribute to viral RNA
decay dynamics with therapy, but is likely to play only a
minor role ... infections
that yielded no p24 synthesis [88]. This demonstrates
that the means of delivery of viral DNA to the nucleus
might influence the level of tran scription observed;
altern...
Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf
... family, are glycosylated proteins of about 50–90 kDa.
The single polypeptide chain of a kininogen contains three
domains resembling family 2 cystatins.
Cystatins competitively inhibit the activity ... energy to the interaction of
cystatin B with cysteine proteases [37]. The sequence of the
second binding loop of the related family 1 cystatin,
cystatin A, differs appreciably from tha...
Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... methyl ester or the amide as
acyl donor.
It appeared that 6-APA and 7-ADCA were able to
efficiently deacylate the phenylglycyl- and p-hydroxyphe-
nylglycyl-enzyme of bF24A, as indicated by, respectively, ... acylase; PAA, phenylacetic acid; PAAM,
phenylacetamide; PAAOM, phenylacetic acid methyl ester; PG, phe-
nylglycine; (H)PGA, (p-hydroxy)-
D
-phenylglycine amide; (H)PGM,
(p-hydroxy)-
D
-p...
Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc
... catalyzes the
methylation of coenzyme M with methylcob(III)alamin [9].
Several isoenzymes of MtaA, designated MtbA and MtsA
have been found [9–11].
The methylation of coenzyme M to methyl-coenzyme ... Ala
exchange.
Determination of specic activity
Methylcob(III)alamin:coenzyme M activity was determined
at 37 C and pH 7.0 by following the demethylation of
methylcob(III)alamin (50 l
M...
Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... Pharmacy and Pharmacology, The University of Bath, UK
Deacetoxycephalosporin C synthase (DAOCS) catalyses the
oxidative ring expansion of penicillin N, the committed step
in the biosynthesis of cephamycin ... position (Scheme 1).
Our understanding of the catalytic mechanism of
DAOCS [8–10] has been significantly advanced by the
determination of the crystal structure of wild-type...
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