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Báo cáo y học: "Tranexamic acid in cardiac surgery: is there a cause for concern" pps

Báo cáo y học:

Báo cáo y học: "Tranexamic acid in cardiac surgery: is there a cause for concern" pps

... withdrawal of aprotinin in certain markets has had two major eff ects.  e fi rst was to cause all of the safety and effi cacy data for aprotinin to be independently examined by regulatory authorities ... observational data is published in Critical Care and suggests an increase in mortality, when compared to data from the aprotinin era, in those patients having surgery when a cardiac chamber is ... acid and tranexamic acid. Epsilon aminocaproic acid has no approval in Europe or Canada for human adminis-tration, leading to the exclusive use of tranexamic acid in these countries. is...
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Báo cáo y học: " Mechanical ventilation in the ICU- is there a gap between the time available and time used for nurse-led weaning?" pot

... The aim of this studywas to identify and quantify discrepancies between the time available for weaning and time actuallyused for weaning. Further, we also wished to analyse patient and systemic ... available for weaning.We found that only 46% of the ventilator shifts available for weaning were actually used for weaning. While physician prescription of weaning was associated with increased ... available wean-ing time, we analysed patient and systemic factors associ-ated with the time available for weaning that was actuallyAvailable time for weaning divided into time used and time not...
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Báo cáo y học:

Báo cáo y học: "Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial" doc

... Hematol-ogy Department (Hospital Universitario de Canarias, La Laguna, Spain) for their invaluable collaboration in this study. This study was supported by FUNCIS (Fundación Canaria de Investigación ... The IR in car-Table 1Part 1. Patient characteristics and associations with inflammatory response after cardiopulmonary bypassVariables Inflammatory response (n = 34) No inflammatory response ... aprotinin [5]. Likeaprotinin, tranexamic acid (TA) inhibits fibrinolysis (that is, plas-min activity and D-dimer formation), but its effect on IR remainsunclear. Additionally, there is evidence...
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Báo cáo y học: "Prehospital cooling in cardiac arrest - the next frontier? Eldar Søreide" ppt

... prehospital cooling had been commenced. Somestudies actually reported active hospital warming ofpatients cooled during ambulance transport. This is prob-ably worse than no cooling at all. This should ... Resuscitation; the American Heart AssociationEmergency Cardiovascular Care Committee; the Council onCardiovascular Surgery and Anesthesia; the Council on Car-diopulmonary, Perioperative, and Critical ... Rodriguez-Nunez A, Sellke FW, Spaulding C,Sunde K, Hoek TV: Post -cardiac arrest syndrome: epidemiol-ogy, pathophysiology, treatment, and prognostication. A Scientific Statement from the International Liaison...
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 Báo cáo y học:

Báo cáo y học: "Prion propagation in vitro: are we there yet"

... propagated and prion infectivity was main-tained.5,6 Several in vitro conversion assays have been introduced over the past 15 years to investigate how PrPC is conformationally altered by ... the amyloid fibril formation in real time. This semi-automated assay was particularly useful in studying kinetics of amyloid fibril conversion and screening potential anti-prion drugs in a high-throughput ... PrPSc after 5 amplification cycles.25 A major change in PMCA was achieved by the incorporation of a programmable sonicator and a 96-well plate format, which enabled high through-put assays.26...
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Báo cáo Y học: DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I and DNA gyrase docx

Báo cáo Y học: DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I and DNA gyrase docx

... promoterand the lacIq1gene are surrounded by a DNA fragmentoriginating from upstream the gyrA gene and a fragmentcontaining the N-terminal part of the gyrA gene. To create a plasmid for integration ... mechanism was operative. In our analysis we focus ontopoisomerase I and DNA gyrase as the main topoisom-erases controlling DNA supercoiling in wild-type E. coli.Recently it was found that also ... when a 10% increase in relaxationactivity leads to a 10% decrease in linking number, norelaxation is prevented and H becomes equal to 0; there is nohomeostasis. When there is no decrease in linking...
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Báo cáo y học: "B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response" docx

... Detailed clinical and labo-ratory data, and serial radiographs of hands and feet wereavailable for all patients (see Table 1).Serum and whole blood samples were obtained from eachpatient. Laboratory ... subtyping, primers and oligonucleotideswere again used as published previously [27].Statistical analysis was performed using the softwarepackage SigmaStat for windows (SPSS Inc., Chicago, ... 1:40. For quantification of antibod-ies against double-stranded DNA, a commercial ELISAsystem was used (VarELISA; Pharmacia Upjohn, Erlangen,Germany). Serum concentrations of IgM, IgG and IgAwere...
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Báo cáo y học: " MAPK signalling in rheumatoid joint destruction: can we unravel the puzzle? " pps

... human RA as well as in other animal models of RA, theactivation of JNK may be caused by another disease-relevantsignalling pathway such as IL-1, which is a potential inducer ofJNK phosphorylation ... previous data, the results of Goertz and colleagues alsoemphasise the role of ERK1/2 as a key integrator ofactivation signals in synovial fibroblasts. In contrast, the datamay be interpreted ... Bennett B, Karin M, Yang L, ManningAM, Firestein GS: c-Jun N-terminal kinase is required for met-alloproteinase expression and joint destruction in inflamma-tory arthritis. J Clin Invest 2001, 108:73-81.3....
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Báo cáo y học: "Microsurgical technique in obstetric brachial plexus repair: a personal experience in 200 cases over 10 years." doc

... spinal accessory nerve, as we need a coun-terbalance to the medial rotators, as rotational dysbalanceat the shoulder level with increasing glenohumeral dys-plasia is a frequent issue [8]. A ... surface to receive sural graftstumps and we look actively for any argument related tomore proximal root damage (intraforaminal rupture, par-tial or total root avulsion) to prevent a grafting ... plan and possibleoutcome.Meanwhile, the sural grafts may be taken and probes ofthe proximal and distal coaptation sites are sent for spe-cialised neuropathological examination.Graft harvestThe...
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Báo cáo y học: " Acquired craniomeningocele in an infant with craniosynostosis: a case report" doc

... Boulay G: The radiological evidence of raised intracranial pressure in children. Br J Radiol 1957, 30:375-377.9. Tajima M, Yamada H, Kageyama N: Craniolacunia in newborn with myelomeningocele. ... severeintracranial hypertension. Meanwhile in the occipitalarea, where the cranium and brain are closely associated,high ICP can result in a bone defect and dura associatedwith brain herniated ... thepatient's parents for publication of this case report andany accompanying images. A copy of the written consent is available for review by the Editor -in- Chief of this jour-nal.AbbreviationsCT:...
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