Báo cáo y học: "Simvastatin attenuates ventilator-induced lung injury in mice" pot

... ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice. Crit Care 2009, 13:R1. 8. Jacobson JR, Barnard JW, Grigoryev DN, ... acute lung injury (ALI), including reduction of pulmonary microvascular leakage, limita- tion of pulmonary leukocyte infiltration, and attenuation of pulmonary and systemic hyper...

Ngày tải lên: 13/08/2014, 21:21

... GGT1-cata- lyzed geranylgeranylation are crucial for TGFb1-induced fib ronectin expression in airway fibroblasts. These find- ings are s upported by studies using human fetal lung fibroblasts demonstrating ... Airway fibroblasts and myofibroblasts are a primary source of ECM proteins, including fibronectin, in subepithelial fibrosis linked to airway remodeling [7]. Targeting and underst...

Ngày tải lên: 12/08/2014, 14:20

... could be explained by differences in the distribution of ventilation, in tissular stress and strain as Commentary Reducing ventilator-induced lung injury and other organ injury by the prone position Peter ... enhance- ment of inflammatory changes in pulmonary tissue [4]. As a result, subsequent pathophysiological pathways contribute to clinical symptoms and morbidity, including...

Ngày tải lên: 12/08/2014, 23:23

... the biopsied patients by carefully correlating clinical findings with microbiologic and pathologic findings using established crite- ria, including those for interstitial lung diseases [12]. For ... Jr, Mountain CF, McMurtrey MJ: Open lung biopsy in immunocompromised patients. Chest 1984, 86:671-674. 24. Chuang ML, Lin IF, Tsai YH, Vintch JR, Pang LC: The utility of open lung biopsy...

Ngày tải lên: 13/08/2014, 08:20

... (SOFA-score) and the severity of lung injury (Lung Injury Score) were not different between survivors and non-survivors (Table 3). The frequency of complications is reviewed in Table 4. Tran- sient ... extracorporeal lung assist systems was stimulated by clinical investigations study- ing ECMO or extracorporeal carbon dioxide removal in rescue situations (life-threatening hypoxae...

Ngày tải lên: 13/08/2014, 11:23

... stabilizing the transient semiquinone, destabilizing the flavin hydroquinone complex and therefore in uencing the FAD reduction potential, support the original hypothesis of its role in proton ... forms by tyrosine 94 and tryptophan 57 in flavodoxin from Anabaena and its in uence on the reduction potentials. Biochemistry 36, 14334– 14344. 22. Pueyo, J.J., Go ´ mez-Moreno, C. & Mayhew,...

Ngày tải lên: 08/03/2014, 23:20

... tolerance in the thymus. Competing interests None declared. References 1. Delon J, Stoll S, Germain RN: Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue. ... autoimmunity to be defined. A model for T-cell activation can be envisaged in which each T cell integrates a range of proinflammatory, stimulatory and regulatory signals to det...

Ngày tải lên: 09/08/2014, 01:23

... alter pain sensitivity at the periphery. These underlying central mechanisms of FM are likely to be reflected in altered supraspinal processing and may originate, in part, at supraspinal sites. The ... These findings suggest that pain catastrophizing exerts influence on pain processing that is independent of the influence of depression and supports the hypothesis that catastrophizing infl...

Ngày tải lên: 09/08/2014, 08:23

... comorbidity or immunodepression. Com- munity health worker intervention[28] and closer moni- toring is necessary for patients in whom the physician perceives any difficulty in understanding the ... whereas being in DOT had no influence. Multivariate analysis confirmed the influence of being an immigrant, living alone, being resi- dents of confined institutions, previous TB treatment, ha...

Ngày tải lên: 12/08/2014, 14:20

... living room chair? In stooping, crouching, or kneeling? In getting up from a stooping, crouching, or kneeling position? In lifting or carrying items under 10 pounds, like a bag of potatoes? In ... of potatoes? In lifting or carrying items over 10 pounds, like a bag of groceries? In standing in place for 15 minutes or longer? In sitting for long periods, say 1 hour? In standi...

Ngày tải lên: 12/08/2014, 15:20