Báo cáo y học: "Activated protein C in severe acute pancreatitis without sepsis" pptx

... In the present issue of Critical Care, Pettila and colleagues report the fi rst single-centred pilot randomized controlled trial of activated protein C (APC) in alcohol- induced acute pancreatitis ... Assessment score as the primary outcome – failed to show any benefi t. In acute pancreatitis, severity is defi ned by the occur- rence of organ failure and/or peri-pancreatic co...

Ngày tải lên: 13/08/2014, 21:21

Ngày tải lên: 13/08/2014, 01:20

... Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care ... ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101:1644-1655. 20. Dellinger RP, Carlet JM, Masur H, Gerlach H, Cala...

Ngày tải lên: 14/08/2014, 07:21

... Chang FY, Ben RJ, Yin HC, Ni YH, Tsai JW, Cheng SH, Wang JT, Liu YC, Cheng YW, Chen ST, Fung CP, Chuang YC, Cheng HP, Lu DC, Liu CJ, Huang IW, Hung CL, Hsiao CF, Ho M: Etiology of community ... ECM, Brandjes DPM, Büller HR, Levi M: Effects on coagulation and fibrinolysis induced by influenza in mice with a reduced capacity to generate activated protein C and a deficiency in plasm...

Ngày tải lên: 13/08/2014, 20:21

... E-selectin expression by endothelial cells [7]. The conversion of protein C to activated protein C is impaired during sepsis, and reduced Commentary Drotrecogin alfa (recombinant human activated protein C) in severe ... Recombinant human protein C Worldwide Evaluation in Severe Sepsis. Available online http://ccforum.com/content/9/4/321 Abstract Introduction Current con...

Ngày tải lên: 12/08/2014, 22:22

... studies can be problematic. In fact, readers should be cautious of economic evaluations that are based exclusively on non-RCTs, when RCT data is available, since Commentary Activated protein C: cost-effective ... at http://ccforum.com/content/11/5/164 © 2007 BioMed Central Ltd See related research by Dhainaut et al., http://ccforum.com/content/11/5/R99 APC = activated protein C; ICU =...

Ngày tải lên: 13/08/2014, 08:20

... throm- bin activatable fi brinolysis inhibitor. Activated throm bin activatable fi brinolysis inhibitor inhibits the chemotactic factors C3 a and C5 a, which could be important for prevention of in ... to systemic in ammation and intense neutrophil in ux into the lung. Activated protein C attenuates coagulation activation and restores  brinolytic capacity but has little e ect on...

Ngày tải lên: 13/08/2014, 20:22

... vasodilator capacity by Escherichia coli endotox- emia. Circ Res 1993, 72:539-551. 5. Reidy MA, Bowyer DE: Scanning electron microscopy: mor- phology of aortic endothelium following injury by endotoxin and ... expression or ACh receptor-NOS coupling. This could be caused by the lack of binding of aPC to EPCR, explaining its lack of effect on the NF- κB pathway, the inflammatory process, monoc...

Ngày tải lên: 12/08/2014, 23:22

... microcirculation, particularly of the intestine, in septic conditions [4,6,8,9]. There is an increasing body of evidence that activated protein C (APC) exerts beneficial effects in the microcirculation. ... improved intestinal microcirculation by protecting functional capillary density as a measure of microvascular perfusion and exerted anti-inflammatory effects by reducing leucocyte...

Ngày tải lên: 13/08/2014, 03:20

... frequently seen in the context of severe septic shock, in particular in patients with meningococcemia, PF also occurs in the rare sce- nario of homozygous or double heterozygous protein C (PC) deficiency ... deficiency [1]. Indeed, the clinical manifestation of a severe PC deficiency in the form of PF has resulted in the description of PF as the clinical symptom of an acu...

Ngày tải lên: 13/08/2014, 21:21