Báo cáo y học: "Sepsis-related stress response: known knowns, known unknowns, and unknown unknown" docx

... Shanghai, and Harbin. For every city, 3-10 districts were randomly selected and within each district, 1-3 elementary schools were cho- sen. Among these districts and schools, 30 districts and 42 ... allergy, family history of HS and OSAS) were significantly associated with an increased likelihood of HS (Model I). After controlling simultaneously for health problems and family hist...

Ngày tải lên: 12/08/2014, 11:22

... pulmonary symptoms and she developed pulmonary hypertension andright ven- tricular hypertrophy. At 6 months ofage she was dis- charged with home oxygen therapy and has been stable for several years ... alveolo-capillary membranes become leaky and intra-alveolar hyaline membranes occur, termed as respiratory distress syndrome (RDS). Surfactant is synthesized and secreted by type II epi...

Ngày tải lên: 12/08/2014, 18:21

... in any GO category. OPSM and ISA have highly enriched biclusters with many annotated genes. In contrast, the Bivisu and k-means biclusters are strongly affected by this filtration as they contain ... & Technology, Yemen. The authors would like to thank Prof Dana Pe'er, Columbia University; Dr Kevien Yip, Yale University and Prof G. Stolovitzky, IBM Computational Biology Ce...

Ngày tải lên: 13/08/2014, 16:20

... pathway and the activation of the p38 MAPK/SAPK2 pathway. Independently of these pathways, protein kinase C (PKC) is able to phosphorylate E lk-1 directly. PKC is activated by diacylglycerol, ... Egr-1 promoter and its potential use for radiation induced gene therapy as recently reported [9,29]. While it is ®rmly established, that the Egr-1 promoter is effectively and quickly activated...

Ngày tải lên: 17/03/2014, 17:20

... were determined by MTS (3-[4,5-dimethylthiazol-2-yl]-5-[3-car- boxymethoxyphenyl]-2-[4-sulfophenyl]-2H-tetrazolium) cell proliferation assay (Promega GmbH, Mannheim, Germany). SFs were seeded at a density of ... signature, and revealed similar quantitative effects. SAIDs finally displayed highest potency and reverted expression of many genes to 'healthy' levels or even beyond. P...

Ngày tải lên: 09/08/2014, 01:22

... overall symptoms and tender points [49]. Androgens Normal physiology and response to stress Dehydroepiandrosterone (DHEA) is the major androgen produced by the adrenal glands, both in women and men. Up ... (metabolic stressor), by running (physical stressor) and by immobilisation (psycho- logical stressor) [77]. However, chronic stress affects the brain serotonergic system quite d...

Ngày tải lên: 09/08/2014, 01:23

Ngày tải lên: 09/08/2014, 06:23

... articular chondrocytes: enhancement by cytokines. J Immunol 1990, 145:690-696. 38. Tiku ML, Yan YP, Chen KY: Hydroxyl radical formation in chondrocytes and cartilage as detected by electron paramag- netic ... Ref-1 and HIF-1 activity in OA chondrocytes (data not shown). Figure 4 Effect of HIF-1α on ATP production and glycolysis in human articular cartilageEffect of HIF-1α on ATP product...

Ngày tải lên: 09/08/2014, 06:23

... they have no competing interests. Authors' contributions KS carried out the SNP genotyping and statistical analysis and drafted the manuscript. JR and SB collected the sample and phenotyped ... HGW and SF carried out the HLA typing. CH participated in study coordination and helped to draft the manuscript. RS conceived of the study, and partici- pated in its design and coo...

Ngày tải lên: 09/08/2014, 14:20

... of Akt phosphorylation, LY294002 (10 μM, LY) was pretreated and the level of FMRP was determined by Western blot. (D) After LY treatment, cell viability was measured by MTT assay, inhibition of ... C, Nakamoto M, Yao X, Chan CB, Yim SY, Ye K, Warren ST, Bassell GJ: Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome. J Neuros...

Ngày tải lên: 10/08/2014, 05:21