Báo cáo y học: " Bench-to-bedside review: Chloride in critical illness" potx

... and maintain viability by down-regulating oxygen consumption, energy requirements and ATP demand [15,16]. In the heart this response is called myocardial hibernation and results in cardiomyocyte hypocontractility ... impair tricarboxylic acid cycle in the heart. Am J Physiol 1991, 260:C50-57. 15. Budinger, GR, Duranteau, J, Chandel, NS, Schumacker, PT: Hibernation during hypoxia in ca...

Ngày tải lên: 13/08/2014, 08:20

... Inhibition of synaptic transmission in the brain Glycine channels Glycine, β-alanine and taurine Inhibition of synaptic transmission in the spinal cord Volume-sensitive chloride channels Cell volume ... by new fi ndings of the structure, molecular biology and physiology of its channels, and better understanding of the clinical eff ects of chloride loading, indicate that alterations...

Ngày tải lên: 13/08/2014, 20:22

... mediated by soluble factors, primarily the proinflammatory cytokines granulocyte colony-stimulating factor and granulocyte/macrophage colony-stimulating factor (GM-CSF), and possibly IL-8 and ... lung injury in humans. The first of these, namely the ‘neutrophilic hypothesis’, suggests that during acute inflammation the cytokines granulocyte colony-stimulating factor and granulocyte/macropha...

Ngày tải lên: 12/08/2014, 19:22

... 222 Critical Care June 2003 Vol 7 No 3 Ryan and Levy The goal of the present review is to question, by critically evaluating the literature, the practice of routinely treating fever in the ... mortality, had less organ damage, and had less evidence of acute lung injury. Interestingly, severe sepsis may be associated with a dimin- ished heat shock response. Lymphocytes obtained from ... th...

Ngày tải lên: 12/08/2014, 19:22

... reperfusion therapy, neuroprotection, induced arterial hypertension and oxygen therapy. Besides being instrumental in this development, imaging in the acute setting brings these physiological concepts ... ischaemic changes [12], yet this is not independently associated with poor clinical outcome [13]. Since the ASPECTS combines swelling and hypodensity, it may not distinguish irreversibly...

Ngày tải lên: 13/08/2014, 08:20

... unknown but there is an extremely useful quantity, known as the 95% confidence interval, which can be obtained in the same way. The 95% confidence interval is invaluable in estimation because it provides ... haemoglo- bin concentration is likely to lie, in postoperative cardiac sur- gical intensive care patients. It does not provide information on the likely range of admission haemoglob...

Ngày tải lên: 12/08/2014, 18:21

... Tri- Council Policy Statement, which, in a subsequent section, states that ‘(b)eyond scrutinizing reports, the REB itself should not normally carry out the continuing ethics review, except in specific ... review in medicine. As recently as the early 1960s, peer review in research was viewed by many investigators and research administrators with the same suspicion that Percival undoubt...

Ngày tải lên: 12/08/2014, 20:20

... decades. Interestingly, critical illness has the potential to become a key testing ground and field of application for these emerging modeling techniques, given the increasing availability of point-of-care ... a Commentary Modeling longitudinal data in acute illness Gilles Clermont CIRM (Center for Inflammation and Regenerative Modeling), Clinical Research, Investigation and Systems Model...

Ngày tải lên: 13/08/2014, 08:20

... 0.90). The Breathing Not Properly study, a multicentre evaluation of BNP [2], the N-terminal pro-BNP Investigation of Dyspnoea in the Emergency Department study [3] and the International Collaborative ... with other clinical findings and investigations. At a cutoff value similar to that found in other clinical studies in acute decompensated heart failure, measurement of N-terminal pro-B...

Ngày tải lên: 13/08/2014, 11:23

... all sorts. Its interesting and diverse biology and ease of breeding in a variety of con- ditions has made Drosophila a favorite laboratory model organism. As the leading player in its genus, Drosophila melanogaster ... 2000, 287:2185-2195. 2. Dobzhansky T: Genetics and the Origin of Species. New York: Colum- bia University Press; 1937. 3. Lewontin RC, Hubby JL: A molecular approach to the...

Ngày tải lên: 14/08/2014, 14:21