Báo cáo y học: "Bench to bedside: A role for erythropoietin in sepsis" pps
Báo cáo y học: "Bench to bedside: A role for erythropoietin in sepsis" pps
... surface receptor
causes conformational change, leading to activation and autophosphorylation of Janus-tyrosine kinase-2 (Jak2). Jak2 phosphorylates nine tyrosine
residues in the intracellular ...
the in ammatory response, and delayed neutrophil
apoptosis has been implicated in mediating tissue
damage in acute respiratory distress syndrome and sys-
temic in ammatory response syn...
Báo cáo y học: "bench-to-bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction" pdf
... hours,
suggesting risk for activated coagulation. Indeed, TF is the
principal activator of the extrinsic coagulation pathway, and as
such is responsible for an intravascular procoagulant state.
Taylor and ... 101:816-823.
24. Gando S, Nakanishi Y, Tedo I: Cytokines and plasminogen acti-
vator inhibitor-1 in posttrauma disseminated intravascular
coagulation: relationship to multiple o...
Báo cáo y học: "Bench-to-bedside review: Severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors" pps
... involves mito-
chondrial impairment and would preferentially target hepato-
cytes. In a preliminary study, L-carnitine dramatically reversed
antiretroviral therapy-related hypertriglyceridaemia in HIV-
infected ... lactaci-
daemia induced by NRTIs is explained by a shift toward
anaerobic metabolism with inverted lactate:pyruvate ratio
[36], by increased apoptosis leading to lactate...
Báo cáo y học: "Bench-to-bedside review: Hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers" ppt
... effects and calcium
channel blockade. Although the availability of free fatty acids
is maintained, myocardial extraction is decreased, making the
heart dependent on carbohydrates as an energy supply. ... heart performance
induced by low-dose insulin was not accompanied by an
increase in myocardial oxygen consumption. Myocardial
uptake of glucose increased significantly, whereas uptake of
la...
Báo cáo y học: "Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock - does the dose matter" pps
... inhibitory
concentration.
patients? Anaesth Intensive Care 2009, 37:323-324.
32. Yano R, Nakamura T, Tsukamoto H, Igarashi T, Goto N, Wakiya Y,
Masada M: Variability in teicoplanin protein binding and its
prediction ... higher
than standard daily dosages of aminoglycosides may be
needed to reach adequate C
max
[42]. Additionally, once-daily
dosing may potentially be less nephrotoxic. Am...
Báo cáo y học: " Bench-to-bedside review: Diaphragm muscle function in disuse and acute high-dose corticosteroid treatment" ppsx
... Stained with hematoxylin and eosin. (c) and (d) Stained with antibody specific for slow
myosin, heavy chain. (e) and (f) Stained with antibody specific for fast myosin, heavy chain. In (c) to ... phosphate (NADPH) oxidase pathway, and mitochondrial oxidant-generating pathway. The
mitochondrial oxidant-generating pathway is key to oxidative damage of diaphragm muscle inactivity. O
2...
Báo cáo y học: " Bench-to-bedside review: A possible resolution of the glucose paradox of cerebral ischemia" pdf
... event and plays a major detrimental role in delayed
neuronal damage postischemia. The findings of Myers and
Yamaguchi [4] that glucose administration preischemia signif-
icantly aggravates the postischemic ... neuronal
death in hippocampal CA1 pyramidal neurons after forebrain
ischemia in hyperglycemic gerbils: amelioration by
indomethacin. Brain Res 2000, 853:93-98.
27. Li PA, Shua...
Báo cáo y học: " Bench-to-bedside review: Inotropic drug therapy after adult cardiac surgery – a systematic literature review" pot
... S, Kinoshita H:
Slow induction of milrinone after coronary artery bypass graft-
ing. Ann Thorac Cardiovasc Surg 2001, 7:23-27.
78. Yamaura K, Okamoto H, Akiyoshi K, Irita K, Taniyama T, Takahashi
S: ... counter-pulsation). Causes are multifactorial but
include myocardial ischaemia during cross-clamping, reper-
fusion injury, cardioplegia-induced myocardial dysfunction,
activation of inflammat...
Báo cáo y học: " Bench-to-bedside review: Oxygen as a drug" pot
... animals and
warrants careful evaluation in selected clinical states and
their animal models.
Effects on inflammation
Tissue hypoxia activates a large variety of vascular and inflam-
matory mediators ... T cells via augmented HIF- 1a (hypoxia inducible
factor- 1a) activity [69], and to weaken local hypoxia-driven
and adenosine A
2A
receptor-mediated pulmonary anti-inflam-
matory mech...
Báo cáo y học: " Bench-to-bedside review: Angiopoietin signalling in critical illness – a future target" pps
... leading to diminished paracellular
permeability [65].
Summary
In the mature vessel, Ang-1 acts as a paracrine signal to
maintain a quiescent status quo, whereas Ang-2 induces or
facilitates an ... stored and rapidly released from WPBs in an
autocrine and paracrine fashion upon stimulation by various inflammatory agents. Ang-2 acts as an antagonist of Ang-1, stops Tie2 signalling,...
Từ khóa: