Ngày tải lên: 13/08/2014, 20:22
... due to the involvement of this signaling pathway in many processes, targeting syndecan 4 is likely to be of benefit in selectively targeting fibrogenic responses (Figure 2). Syndecan 4 is a receptor ... significant morbidity. There is no therapy for the fibrosis observed in SSc; indeed, the underlying cause of the scarring observed in this disease is unknown. Transforming gr...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: " JNK activation is responsible for mucus overproduction in smoke inhalation injury" potx
... mucin secretion i n theairwayofmicebyusingthePASstain.ThePAS stain is mainly used for stai ning str uctures containing a high pro portion of carbohydrate macromolecules (glyco- gen, glycoprotein, ... counterstained lightly wit h hematoxylin for one min. The quantity of MUC5AC protein production in the airway was assessed by measuring the percentage of MUC5AC positive cells in the airw...
Ngày tải lên: 12/08/2014, 13:22
Báo cáo y học: "Sedation practice: is it time to wake up and embrace change" docx
... being incorporated into everyday clinical practice. In the previous issue of Critical Care, Martin and co-workers, [1] report the results of a survey examining changes in sedation management in ... management in German intensive care units (ICUs). This review of 214 ICUs is made more informative by their use of the same questionnaire used by this group in 2002, allowing changes i...
Ngày tải lên: 13/08/2014, 08:21
Báo cáo y học: "Atrial fibrillation is not just an artefact in the ICU" doc
... protein before onset of AF is another factor highlighting the role of in ammation in the genesis of AF in the ICU. Nevertheless, we have to keep in mind that in ammation alone is probably insuffi ... previous fi ndings on the hypothesis of an in ammatory substrate in AF onset [2]. AF is the most signifi cant arrhythmia in the ICU. e risk to develop AF in the ICU is la...
Ngày tải lên: 13/08/2014, 21:20
Báo cáo y học: "Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi" pot
... segregation in trypanosomes is more streamlined than in other organisms, or that the proteins involved are highly divergent. Whatever the reason, resolution of these issues should provide new insights into ... million people, mainly in the developing world. Trypanosomatids are early diverging eukaryotes and share several unusual genetic traits [20]. Protein coding genes lack RNA polym...
Ngày tải lên: 14/08/2014, 20:22
Báo cáo y học: " Intramuscular electroporation with the pro-opiomelanocortin gene in rat adjuvant arthritis" doc
... separated by 2 minutes, with a current of 100 V/cm.) Injection of CFA Arthritis was induced by injecting 0.3 ml of 5.0 mg/ml CFA (consisting of heat-killed Mycobacterium butyricum in Introduction We ... activity of ACTH and endorphin. The increased synthesis of ACTH and endor- phin might therefore also explain the balance between proinflammatory and anti-inflammatory cascade. Our study is...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: " Predictors of infusion reactions during infliximab treatment in patients with arthritis" docx
... some DMARDs [14]. The findings of increased risk for developing infusion reactions in ANA-positive RA patients in our study support the plausibility of underlying immunogenetic mecha- nisms of drug-related ... with infliximab and use of infliximab without methotrexate in patients with RA are inde- pendent risk factors for developing infusion reactions; and that the risk is considerabl...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: " Brain size and brain/intracranial volume ratio in major mental illness" doc
... visually examined sequentially, slice by slice, in detail. The accuracy of the inner skull border wa s determined visually, necessary corrections were made using hand tracing, and the resulting ... the resulting bone and tissue external to this boundary was stripped leaving ICV containing brain and CSF for that slice. Next the estimate of CSF - brain boundary was examined and corrected visu...
Ngày tải lên: 11/08/2014, 16:22
Báo cáo y học: " Identification of critical residues of influenza neuraminidase in viral particle release" doc
... 8.0) containing 100 mM glycine, once with ice-cold PBS (pH 8.0), and then lysed in Triton-X 100 lysis buffer containing a protease inhibi- tor cockt ail. Biotinylated surface proteins were separated from ... Key Laboratory of Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing 100052, China. Authors’ contributions JRT, YG,...
Ngày tải lên: 11/08/2014, 21:21