Báo cáo y học: "Activated protein C for H1N1 influenza? More work to do" potx

... pneu- monia due to H1N1 cause sytemic and pulmonary activa - tion of coagulation and inhibition of fi brinolysis in the lungs similar to what is known to occur in community- acquired bacterial pneu ... thrombin formation could prevent the activation of throm- bin activatable fi brinolysis inhibitor. Activated throm bin activatable fi brinolysis inhibitor inhibits the chemotactic fact...

Ngày tải lên: 13/08/2014, 20:22

... American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society ... were matched in patient characteristics, comorbidities, and physiologic variables in a 1:1 propensity-matched analysis (108 received rhAPC, 108 did not). Mean Acute Physiology An d Chronic Health...

Ngày tải lên: 14/08/2014, 07:21

Ngày tải lên: 13/08/2014, 01:20

... (though arguably only after RCTs have confirmed medication efficacy). Studies like the present one are therefore important. Dhainaut and colleagues prospectively collected clinical outcome data in ... University of Calgary and Calgary Health Region, Calgary, Alberta, T2L 2K8, Canada 2 Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, T2L 2K8, Canada 3...

Ngày tải lên: 13/08/2014, 08:20

... Chang FY, Ben RJ, Yin HC, Ni YH, Tsai JW, Cheng SH, Wang JT, Liu YC, Cheng YW, Chen ST, Fung CP, Chuang YC, Cheng HP, Lu DC, Liu CJ, Huang IW, Hung CL, Hsiao CF, Ho M: Etiology of community ... Effects on coagulation and fibrinolysis induced by influenza in mice with a reduced capacity to generate activated protein C and a deficiency in plasminogen activator inhibitor type 1. Circ...

Ngày tải lên: 13/08/2014, 20:21

... Shankar-Hari and Duncan Wyncoll* See related research by Pettila et al., http://ccforum.com/content/14/4/R139/abstract COMMENTARY *Correspondence: Duncan.Wyncoll@gstt.nhs.uk Guy’s and St Thomas’ ... the primary outcome – failed to show any benefi t. In acute pancreatitis, severity is defi ned by the occur- rence of organ failure and/or peri-pancreatic complica- tions. Severe acute pancreatit...

Ngày tải lên: 13/08/2014, 21:21

... vasodilator capacity by Escherichia coli endotox- emia. Circ Res 1993, 72:539-551. 5. Reidy MA, Bowyer DE: Scanning electron microscopy: mor- phology of aortic endothelium following injury by endotoxin and ... vascular reactivity, endothelium CD31-PECAM1 immunohistochemistry, plasma coagulation factors and monocyte tissue factor (TF) expression were performed 5 days (D5) after onset of endoto...

Ngày tải lên: 12/08/2014, 23:22

... versus LPS. APC, acti- vated protein C- only group; LPS, lipopolysaccharide-only group; LPS + APC, activated protein C- treated endotoxaemic group. Available online http://ccforum.com/content/10/6/R157 Page ... of inflammatory cytokines, it increased mucosal and muscular functional capillary density (p < 0.001 and p < 0.05, respectively) and reduced the number of firmly adhering...

Ngày tải lên: 13/08/2014, 03:20

... meningococcemia, PF also occurs in the rare sce- nario of homozygous or double heterozygous protein C (PC) deficiency [1]. Indeed, the clinical manifestation of a severe PC deficiency in the form ... monitor (physician) for standardized (form-based clinical reporting) data collection. For ana- lysis, patients were stratified into three outcome groups by survival to hospital discharg...

Ngày tải lên: 13/08/2014, 21:21

... highly effective when taken correctly, incorrect use can lead to the development of resistance. Contrastingly, adherence levels which are too low to generate resistance do not decrease or delay ... measure- ments, which are typically every six months in patients with HIV. The limitations of this hypothesis as applied to clinical practice include the access to and costs of sequenc- ing...

Ngày tải lên: 10/08/2014, 05:21