Báo cáo y học: "Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation" ppt

... monocytes. In contrast, IL-10- induced HLA-DR down-regulation only occurs among CD14 LOW CD16 + monocytes. Key messages • Down-regulation of HLA-DR on monocytes during systemic inflammation ... monocytes. In contrast, the correlation between levels of IL-10 and altered HLA-DR expression was only found for CD14 HIGH monocytes. Accordingly, Figure 7 Modulation of HLA...

Ngày tải lên: 13/08/2014, 20:21

... effects of albuterol isomers on the IAR of the airways (Figure 1A) where as the second part of the study was focused on studying the effect of albuterol isomers on AHR. The latter part of the study ... minutes. Control animals received saline-only aerosol. On day 25 the mice were asses sed for airway hyperresponsiveness and pulmonary cellular infiltrates. Lung mechanics was...

Ngày tải lên: 12/08/2014, 13:22

... differences. Neuronal differentiation of PC12 cells by Hyper-CNTF In a second bioassay, we investigated the potential role of Hyper-CNTF in neuronal cell differentiation. The morphology of rat pheochromocytoma ... Germany; 4 Department of Medicine, Section Pathophysiology, Johannes Gutenberg University of Mainz, Germany; 5 Department of Biochemistry, Christian Albrechts University...

Ngày tải lên: 22/02/2014, 07:20

... constitutes the bulk of the fatty acid at the sn-2 position of 1-alkyl-2-acyl-GPC under resting conditions [70]. Upon cell activation, most of this AA is replaced by other fatty acids. Finally, ... activation is accompanied by an increase in PAF biosynthesis via acetylation of 1-alkyl-2-lyso-GPC by acetyl transferase (Fig. 8, f) activity, competition for 1-alkyl-2-lyso-GPC intermediat...

Ngày tải lên: 22/02/2014, 07:20

... [54]. HydA belongs to a new class of Fe-hydrogenases HydA of C. reinhardtii, the first isolated gene encoding a hydrogenase of a photosynthetic eukaryotic cell, repre- sents a novel type of Fe-hydrogenases. ... they often catalyze the reduction of pr otons with a high specific activity to yield hydrogen [16]. Interestingly, Fe-hydrogenases were not found in cyanobacteria, the free-liv...

Ngày tải lên: 08/03/2014, 22:20

... experiment, because of the shortage of cellular salvage pathways and the complete inhibition of TEP1 function by high concentra- tions of antisense oligonucleotides, telomerase activity was dramatically diminished. ... Alternatively, hTR and hTERT may play a minimal catalytic activity in telomerase, while the assembly of other telomerase subunits may amplify the enzyme function. In...

Ngày tải lên: 17/03/2014, 23:20

... partially, recover from IL-1- induced degradation by synthesizing new GAG but that the ultimate rate of recovery may be dependent on the degree of initial depletion. By monitoring the spatially localized ... advantage of the characteristic spatial heterogeneity of IL-1-induced GAG depletion to study the relative replenishment rates between regions of varying severity of GAG depl...

Ngày tải lên: 09/08/2014, 01:21

... amount of glyceraldehyde-3-phosphate dehy- drogenase to compensate for variations in quantity and for differences in reverse transcription efficiency. Briefly, 3 µl of the cDNA was in a reaction of ... for- mation in the developing embryo by antagonizing Ang-1- induced autophosphorylation of Tie2 [6]. Transgenic mouse models of Tie2/Ang-1 result in embryonic lethality due to absence...

Ngày tải lên: 09/08/2014, 03:24

... intimal layer. In two of these individuals a minority of synovial samples also showed microscopically normal regions with minimal infil- tration of inflammatory cells and an intimal layer of normal thickness ... (one to two cells thick). The synovia of the six non-RA patients showed inflamed and noninflamed regions. These inflamed regions displayed intimal layer thickening and some...

Ngày tải lên: 09/08/2014, 03:24

... receptor responsible for the controlled migration of B Figure 5 Chemokine receptor CCR6 + expression on B cell subpopulationsChemokine receptor CCR6 + expression on B cell subpopulations. The percentage ... characterized by chronic inflammation of the synovial membrane and the formation of a pannus, which leads to swollen joints and finally to joint destruction. Inflammatory cell...

Ngày tải lên: 09/08/2014, 06:23