Báo cáo y học: "Drotrecogin alfa (activated) may attenuate severe sepsis-associated encephalopathy in clinical septic shock" pot

... blocking apoptosis in brain endothelial cells [29]. The present study suggests that APC may attenuate SAE but only in patients with clinically more severe neurological dysfunction. This is in line ... 10.1186/cc8947 Cite this article as: Spapen et al., Drotrecogin alfa (activated) may attenuate severe sepsis-associated encephalopathy in clinical septic shock...

Ngày tải lên: 13/08/2014, 20:21

... is adequately powered to be able to detect differences in outcome beyond 28 days. Competing interests ICNARC conducts paid for analyses for industry, including Eli Lilly and Company. All authors ... Lilly and Com- pany sponsored, nonrandomized, open-label study) [13], the characteristics of patients receiving DrotAA in our study indi- cated that they were only slightly younger or similar...

Ngày tải lên: 13/08/2014, 10:20

... NoNoNoNoYesNoNoNoYesNo DrotAA-related 2 YesNoNoNoYesYesNoYesNoNo Disease category PF Yes Yes No No No Yes Yes No Yes Yes MEN No No Yes Yes Yes Yes No Yes Yes No MD YesNoYesNoNoYesNo NoNoYes Baseline characteristics Age (years) 19204767732441775140 Protein C level ... During infusion After infusion Relative day of event onset 1 112356671118 Bleeding event ICH No No Yes Yes Yes Yes Yes Yes Yes...

Ngày tải lên: 12/08/2014, 22:21

... Administration of Drotrecogin Alfa (Activated) in Early Stage Stage Sepsis; APACHE = Acute Physiology and Chronic Health Evaluation; DrotAA = drotrecogin alfa (activated); PROWESS = Recombinant ... variability and very low proportion of patients with severe sepsis receiving DrotAA in many western European countries [8] suggest that many clinicians are having difficulties iden...

Ngày tải lên: 13/08/2014, 03:20

... A, Steingrub JS, Garber GE, Helterbrand D, Ely EW, et al., for the Recombinant Human Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group: Efficacy and safety of recombinant ... al., for the Administration of Drotrecogin alfa (activated) in Early Stage Severe Sepsis (ADDRESS) Study Group: Drotrecogin alfa (acti- vated) for adults with severe sepsis and a low...

Ngày tải lên: 13/08/2014, 03:20

... receiving low- dose heparin [3]. In the Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) study [1], Abraham and colleagues assessed the role of DrotAA in ... 347:1030-1034. 4. Baillie JK, Murray G: Drotrecogin alfa (activated) in severe sepsis. N Engl J Med 2006, 354:94-96. 5. Friedrich JO: Drotrecogin alfa (activated)...

Ngày tải lên: 13/08/2014, 03:20

Ngày tải lên: 13/08/2014, 03:20

... expression of PPARγ in OA cartilage may, at least in part, be involved in increased expression of inflammatory and catabolic genes, promoting articular inflammation and cartilage degradation. In addition, ... of mitogen-activated protein kinases and tyrosine kinases on IL- 1-induced NF-κB activation and iNOS expression in bovine articular chondrocytes. Nitric Oxide 2002, 6:35-44. 4...

Ngày tải lên: 09/08/2014, 10:20

... amounts of sialylated Hex3 glycoforms were indicated. b Minor amounts of Hex2 and Hex3 glycoforms lacking acetyl groups or containing a second glycyl group were indicated. c Very minor amounts ... of the a cetyl and glycyl groups as well as glycose sequence was provided by ESI tandem mass s pectrometry ( MS/MS ) in the positive ion mode following on-line separation by capillary electro- pho...

Ngày tải lên: 31/03/2014, 21:21

... Finally, we may have been biased into thinking that blacks are more likely to carry weapons as a result of pre- vailing prejudices. However, we also do not intend to minimize the significantly ... The findings from this study may assist in the informed design of interven- tion programs aimed to reduce adolescent perpetrated injury and death resulting from weapon use. Methods Sampling st...

Ngày tải lên: 08/08/2014, 23:20