Báo cáo y học: "Renal hypoperfusion and impaired endothelium-dependent vasodilation in an animal model of VILI: the role of the peroxynitrite-PARP pathwa" ppt
Báo cáo y học: "Renal hypoperfusion and impaired endothelium-dependent vasodilation in an animal model of VILI: the role of the peroxynitrite-PARP pathwa" ppt
... reproduction in any medium, provided the original work is properly cited.ResearchRenal hypoperfusion and impaired endothelium-dependent vasodilation in an animal model of VILI: the role of the peroxynitrite-PARP ... peroxynitrite attenuates VILI and renal hypoperfusion and dysfunction, by maintaining endothelium-dependent vasodilation and decreasing inflammation and tissue injury.Materials and methods Animal ... is involved in renal hypoperfusion, impaired endothelium-dependent vasodilation and resultant dysfunction, and injury, in a model of lung injury.IntroductionMechanical ventilation (MV) remains...
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Báo cáo y học: "Reduced number and impaired function of circulating progenitor cells in patients with systemic lupus erythematosus" pot
... anal-ysis and drafting of the manuscript. KL was in charge of the recruitment of patients and their demography and performed the ELISA measurements. XS participated in the culturingPBMNCs and ... functionality assays. CK participated in the design of the study and helped to draft the manuscript. MLparticipated in the design and coordination of the study and helped to draft the manuscript. ... provided the clinical back-ground, was in charge of the recruitment of patients and par-ticipated in design and drafting of the manuscript. MHparticipated in the design and coordination of the...
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Báo cáo y học: "Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysi" ppsx
... human leukocyte antigen (HLA)-DRon monocytes and the impairment of cellular immunity in sep-sis, including decreased production of proinflammatorycytokines, impaired antigen presentation, and ... number of immune dysfunctions have been reported in sep-sis, including apoptosis of T lymphocytes and B lymphocytes,altered cellular cytokine production, increased levels of the anti-inflammatory ... patients and controls even atbaseline, suggesting that proteolytic processing and/ or secre-tion of IL-1β rather than synthesis and intracellular accumula-tion of inactive pro-IL-1β in monocytes...
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Báo cáo y học: " Renal function and thromboprophylaxis in critically ill patients" ppsx
... Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insu ciency with low molecular weight heparin dalteparin; An assessment of safety and pharmacodynamics: The DIRECT ... Occurrence of thrombosis and haemorrhage, relationship with anti-Xa, anti-IIa activities, and D-dimer plasma levels in patients receiving a low molecular weight heparin, enoxaparin or tinzaparin, ... receiving thromboembolic prophylaxis with standard doses of enoxaparin. Thromb Res 2002, 105:201-204.7. Lim W, Dentali F, Eikelboom JW, Crowther MA: Meta-analysis: low-molecular-weight heparin and...
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Báo cáo y học: "Ozone Therapy and Hyperbaric Oxygen Treatment in Lung Injury in Septic Rats"
... experimental and clinical studies in animal models and human beings are needed to un-derstand molecular elements, ligand and receptors, involved in the mode of action of ozone and HBO. Finally, according ... proinflammatory cytokines levels, MPO activities and histopathological injury scores significantly. The in- crease in the antioxidant enzyme activities, the sup-pression of IL-1β levels and the ... important to decrease morbid-ity and mortality. This study was designed to define the efficacy of OT as an adjuvant to antibiotherapy in an experimental rat model of sepsis. In terms of their...
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Báo cáo y học: "Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures" doc
... totalbody clearance of these compounds, with the remainingamounts being eliminated in unknown proportions by the exo-crine glands and by the respiratory and gastrointestinal tracts[11,12]. The ... laboratory analyses. TL and EWSrecruited and examined patients and controls, and collectedclinical information. WEW performed the statistical analyses.JBW wrote the manuscript, and TL, WEW, DSP, and ... lines of evidence implicate NO in the pathogenesis of joint inflammation. Rodents in animal models of arthritis gener-Figure 3NOx/creatinine ratios in urine and serumNOx/creatinine ratios in...
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Báo cáo y học: " T cells and post menopausal osteoporosis in murine models" doc
... in elucidating the crosstalk between the immune system and bone and in uncovering the mechanism by which sex-steroids, infection and inflammation lead to bone loss by disregulating Tlymphocyte ... treated with the TNF inhibitor TNF bindingprotein [16] are protected from ovx-induced bone loss. The presence of increased levels of TNF in the BM of ovxanimals and in the conditioned media of peripheral ... TNF, a cytokine thatenhances OC formation by upregulating the stromal cellproduction of RANKL and M-CSF [12] and by augmenting the responsiveness of OC precursors to RANKL [13].Furthermore,...
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Báo cáo y học: "Thymic function and T cell parameters in a natural human experimental model of seasonal infectious diseases and nutritional burden" potx
... resulted in invasion of the thymus by day 14; accompanied by severe thymic atro-phy[17]. In humans, postmortem studies show thymic involu-tion in the severely malnourished[18]. Furthermore,cytokines ... Scand J Immunol 1997,45:637-644.54. Yao XS, Diao Y, Sun WB, Luo JM, Qin M, Tang XY: Analysis of the CDR3length repertoire and the diversity of TCR alpha chain in humanperipheral blood T lymphocytes. ... werecruited t wo groups of young a dults (18-23 y) born in the hungry/high infection and harvest/low infection and, based on the known susceptibility of the thymus tonutritional insult and our previous...
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Báo cáo y học: " Fat distribution and longitudinal anthropometric changes in HIV-infected men with and without clinical evidence of lipodystrophy and HIV-uninfected controls: A substudy of the Multicenter AIDS Cohort Study" potx
... agents and 34 due todiabetes, and 35 due to inconsistent antiretroviral therapylevel in the 2 years preceding the first clinical evidence of lipodystrophy. Of the remaining 77 men, matched HIV-infected ... better understand body shape changesover time, we examined the relationship between thesedata and longitudinal changes in anthropometry in thesethree groups over the 6 years following the cross-sectionalassessment.MethodsStudy ... studyprotocols and forms, and each participant provided writ-ten informed consent both for the overall study and thissubstudy.Sampling methods for the Lipodystrophy SubstudyBeginning in April...
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Báo cáo y học: "Technical phosphoproteomic and bioinformatic tools useful in cancer research" potx
... forphosphor-quantitative analysis of signalling networksidentifying and quantifying 222 tyrosine phosphorylatedpeptides, obtaining an extremely high percentage of sig-nalling nodes covered. Ziwei Yu ... combined with IMAC and resulted in greater recovery and identification by MS of interest-ing phosphorylated peptides originating from yeast pher-omone signalling pathway and membrane proteinsrespectively ... incorporated into the AQUA peptideby using isotopically “heavy” amino acids during the synthesis p rocess of the peptide of interest (native pep-tide). The synthetic peptide has a mass increase of e.g.10Dal...
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