Báo cáo y học: "Where does the lactate come from? A rare cause of reversible inhibition of mitochondrial respiration" pdf

... the lactate/ pyruvate ratio [8]. All in all, anaerobic energy metabolism is characterized by hyperlactatemia associated with an elevated lactate/ pyruvate ratio, greater glucose utilization and ... phosphorylation [7], thereby inhibiting ATP synthesis and reoxidation of NADH.  is leads to a decrease in the ATP/ADP ratio and an increase in the NADH/NAD ratio. A decrease in...

Ngày tải lên: 13/08/2014, 20:21

... encompass all aspects of basic and clinical science that impact on abating the spread of AIDS; it is a multidisciplinary journal that aims to keep scientists and clinicians abreast of the latest research ... efforts in the spread of HIV-1 can tame the scourge considerably. Dissemination of the latest knowledge in basic science and its application to AIDS therapy and prev...

Ngày tải lên: 10/08/2014, 05:20

... synthesis purification and characterization of six Tat variants. J Biol Chem 1999, 274:11473-11478. 11. Ranga U, Shankarappa R, Siddappa NB, Ramakrishna L, Nagendran R, Mahalingam M, Mahadevan ... structural variations of Tat may have on these functions. Finally, we will also discuss the role of Tat as a potential vaccine candidate. Structures of Tat variants HIV-1 Tat is a smal...

Ngày tải lên: 12/08/2014, 23:21

... splicing. Yet according to Raible et al., the last common ancestor between vertebrates and annelids had nearly as many introns as humans. So, evolution has hardly affected the gene structure of the ... 3.5 picograms (pg) of DNA. According to the Animal Genome Size Database [9] this is several times more than the haploid genome size of the vast majority of invertebrates, in...

Ngày tải lên: 14/08/2014, 16:20

... to the average and 15 to the standard deviation. This permits direct comparison between indi- vidual scores with the normative data from the same age range. Data synthesis Meta-analyses were carried ... variation between the results of the various studies and an estimate of the overall effect size of all the studies together considering the data available for each stud...

Ngày tải lên: 09/08/2014, 01:21

... col- laborative and two-way and thus, relationship-centered [11]. Methods Clinical context Primary care is the level of health care that: acts as the patient's gateway into the healthcare system ... Canada, 4 Department of Medicine, University of California, Los Angeles, USA, 5 Ottawa Health Research Institute, Ottawa, Canada, 6 Department of Medicine, University of O...

Ngày tải lên: 11/08/2014, 05:21

... patients. The capillary supply is usually assessed by counting the number of capillaries around each fibre (CAF) or by com- puting the ratio between CAF and the area of the muscle fibre (CAFA). ... of the capillary- to-fibre ratio (C:F i , i.e. the sum of the fractional contribu- tions of all capillary contacts around the fibre). We sug- gest that the C:F i is...

Ngày tải lên: 12/08/2014, 11:22

... reported no past history of any skin disease. In addition, there was no history of a similar illness in the family. An examination revealed multiple small papules over the lower part of his left ... to fatal cardiovascular and respiratory collapse. Cutaneous features can be both acute and chronic. We report a case of persistent lichen planus-like eruption in a young boy afte...

Ngày tải lên: 11/08/2014, 17:21

... details 1 Department of Human Anatomy and Physiology, University of Padova, Italy. 2 Department of Neuroscience, University of Padova, Italy. 3 Department of Pharmaceutical Sciences, University of Parma, Italy. 4 Department ... treatment of glioma Marco Redaelli 1 , Carla Mucignat-Caretta 1 , Andrea Cavaggioni 1 , Antonio Caretta 3 , Domenico D’Avella 2 , Luca Denaro 2 , Sandro...

Ngày tải lên: 12/08/2014, 02:20

... jugular and femoral veins and the femoral artery for the placement of hepatic venous, and pulmonary arterial and femoral arterial catheters, a laparatomy was performed and a urinary bladder catheter was ... that mitochondrial damage and dysfunction play an important role in the pathogenesis of sep- sis-induced organ failure [23,24]. Mitochondrial dysfunction can be character...

Ngày tải lên: 13/08/2014, 11:22