Báo cáo y học: "Where does the lactate come from? A rare cause of reversible inhibition of mitochondrial respiration" pdf
Báo cáo y học: "Where does the lactate come from? A rare cause of reversible inhibition of mitochondrial respiration" pdf
... the lactate/ pyruvate ratio [8].All in all, anaerobic energy metabolism is characterized by hyperlactatemia associated with an elevated lactate/ pyruvate ratio, greater glucose utilization and ... phosphorylation [7], thereby inhibiting ATP synthesis and reoxidation of NADH. is leads to a decrease in the ATP/ADP ratio and an increase in the NADH/NAD ratio. A decrease in the ATP/ADP ratio ... should theoretically be accompanied by hypoxic hyperlac-tatemia. Cardiogenic shock, as demonstrated previously [5], is associated with hyperlactatemia with a very high lactate/ pyruvate ratio....
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Báo cáo y học: "What does the marriage of Open Access with online publication bring" docx
... encompass all aspects of basic and clinical science that impact on abating the spread of AIDS; it is a multidisciplinary journal that aimsto keep scientists and clinicians abreast of the latestresearch ... efforts in the spread of HIV-1 can tame the scourge considerably.Dissemination of the latest knowledge in basic scienceand its application to AIDS therapy and prevention is of paramount importance. ... immediately and permanently available onlinewithout charge or any other barriers to access. In an OpenAccess journal, the communication has to be bi-direc-tional for the journal's success and...
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Báo cáo y học: "What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?" ppsx
... synthesis purificationand characterization of six Tat variants. J Biol Chem 1999,274:11473-11478.11. Ranga U, Shankarappa R, Siddappa NB, Ramakrishna L, Nagendran R,Mahalingam M, Mahadevan ... structural variations of Tat may have on these functions. Finally, we will alsodiscuss the role of Tat as a potential vaccine candidate.Structures of Tat variantsHIV-1 Tat is a small nuclear protein ... was probably due to an acquiredimmunity and not an innate immunity that is statisticallyobserved in less than 5% of the population. Ten years after the publication of the above study, the 23...
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Báo cáo y học: "Where is the difference between the genomes of humans and annelids" pot
... splicing. Yet according toRaible et al., the last common ancestor between vertebratesand annelids had nearly as many introns as humans. So,evolution has hardly affected the gene structure of the ... 3.5picograms (pg) of DNA. According to the Animal GenomeSize Database [9] this is several times more than the haploidgenome size of the vast majority of invertebrates, includingDrosophila melanogaster ... invertebrates have a genome size comparable to that of humans [10,11]. The well-known example of the unicellularAmoeba dubia, with a genome 200 times larger than that of humans [9], demonstrates that...
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Báo cáo y học: "Estimated intelligence quotient in anorexia nervosa: a systematic review and meta-analysis of the literature" pot
... to the average and 15 to the standarddeviation. This permits direct comparison between indi-vidual scores with the normative data from the sameage range.Data synthesisMeta-analyses were carried ... variation between the results of the various studies and an estimate of the overall effect size of all the studies together considering the data availablefor each study included in the meta-analysis ... mea n and the standard deviation of the norm group are regarded as known (based on a largesample size), a bias correction of the standard error isnot necessary. The effect siz es and standard...
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Báo cáo y học: "EXACKTE2: Exploiting the clinical consultation as a knowledge transfer and exchange environment: a study protocol" pptx
... col-laborative and two-way and thus, relationship-centered[11].MethodsClinical contextPrimary care is the level of health care that: acts as the patient's gateway into the healthcare system ... Canada, 4Department of Medicine, University of California, Los Angeles, USA, 5Ottawa Health Research Institute, Ottawa, Canada, 6Department of Medicine, University of Ottawa, Ottawa, Canada, ... correlationsbetween any two variables of 0.16 or higher (in absolutevalue) with alpha = 0.05 and beta = 0.20.Statistical analysesTo further assess evidence of the validity and reliability of the relationship-centered...
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Báo cáo y học: "Alterations in the muscle-to-capillary interface in patients with different degrees of chronic obstructive pulmonary disease" pps
... patients. The capillary supply is usually assessed by counting the number of capillaries around each fibre (CAF) or by com-puting the ratio between CAF and the area of the musclefibre (CAFA). ... of the capillary-to-fibre ratio (C:Fi, i.e. the sum of the fractional contribu-tions of all capillary contacts around the fibre). We sug-gest that the C:Fi is the capillary variable mainly ... (CAFA). CAFA is a parameter based on the diffu-sion distance between the capillary and the centre of the fibre. Capillary parameters essentially determining the diffusion distance may not detect actual...
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Báo cáo y học: "Lichen planus-like eruption resulting from a jellyfish sting: a case report" pot
... reported no pasthistory of any skin disease. In addition, there was nohistory of a similar illness in the family.An examination revealed multiple small papules over the lower part of his left ... to fatal cardiovascular and respiratory collapse. Cutaneous features can be bothacute and chronic. We report a case of persistent lichen planus-like eruption in a young boy after a jellyfish ... no regional lymphadeno-pathy or mucosal involvement.Histopathology with hematoxylin and eosin stain revealed a dense perivascular accumulation of mononuclear cellsimmediately beneath the dermoepidermal...
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Báo cáo y học: "Bovine herpesvirus 4 based vector as a potential oncolytic-virus for treatment of glioma" pps
... details1Department of Human Anatomy and Physiology, University of Padova, Italy.2Department of Neuroscience, University of Padova, Italy.3Department of Pharmaceutical Sciences, University of Parma, Italy.4Department ... treatment of gliomaMarco Redaelli1, Carla Mucignat-Caretta1, Andrea Cavaggioni1, Antonio Caretta3, Domenico D’Avella2,Luca Denaro2, Sandro Cavirani4, Gaetano Donofrio4*Abstract The ... was repeated* Correspondence: gaetano.donofrio@unipr.it4Department of Animal Health, University of Parma, ItalyFull list of author information is available at the end of the articleRedaelli...
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Báo cáo y học: "Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration" doc
... jugular and femoralveins and the femoral artery for the placement of hepaticvenous, and pulmonary arterial and femoral arterial catheters, a laparatomy was performed and a urinary bladder catheterwas ... that mitochondrial damage anddysfunction play an important role in the pathogenesis of sep-sis-induced organ failure [23,24]. Mitochondrial dysfunctioncan be characterized by inability of the ... norepinephrine was added.Blood samplingBlood samples for the measurement of haemoglobin, lactate and blood gases were taken at baseline and every 2 hoursafterward from pulmonary and femoral arteries and...
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