... Most likely, the down-regulation of fibrinolytic activity can be explained at leastpartially by upregulation of PAI-1, the main inhibitor ofthe fibrinolytic system. As such, severe influenza ... vitro investigations indicatesthat APC may stimulate fibrinolysis by inhibiting themain inhibitor of this system, PAI-1 [29,30]. To study theeffect of lethal influenza A infection on fibrinolysis ... Takatsuki K: Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production. Am J Physiol 1997, 272:L197-L202.33. Suzuki K, Gabazza C, Hayashi T, Kamada...