Báo cáo y học: " Ventilator-induced endothelial activation and inflammation in the lung and distal organs" docx
Báo cáo y học: "Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis" pps
... project running and data analysis, and drafted the manu-script. TM, SF, YI, YK, and HM assisted in the study design and coordination, and oversaw the data analysis and drafting of the manuscript. ... interests The authors declare that they have no competing interests.Authors' contributionsHI and MJ designed the study. NHK, MT, YY, and FCM assisted in the studydesign, oversaw the project ... phosphate-bufferedsaline; PC5: phycoerythrin-cyanin 5.1; PE: phycoerythrin; SD: standard devia-tion; SSc: systemic sclerosis; TGF-β: transforming growth factor-β; TNF-α:tumour necrosis factor-α.Competing interestsThe...
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Báo cáo y học: " Ventilator-induced endothelial activation and inflammation in the lung and distal organs" docx
... shown).Figure 2 Ventilator-induced endothelial activation and inflammation in pulmonary tissueVentilator-induced endothelial activation and inflammation in pulmonary tissue. In total lung homogenates, ... may cause endothelial activation in healthy mice, not only in the lung but also in organs distal to the lung. To determine endothelial activation in these organswe assessed de novo synthesis of ... inflamed pulmonary tissue, which in turn mayFigure 3 Ventilator-induced endothelial activation and inflammation in hepatic tissueVentilator-induced endothelial activation and inflammation in hepatic...
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Báo cáo y học: "Silencing CD36 gene expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the rat" pdf
... via inhibiting the activation of L-TGF-Hydroxyproline content of rat lungsFigure 3Hydroxyproline content of rat lungs. There was no sig-nificant difference in the hydroxyproline content of the ... could reduce hydroxyproline content in lung Hydroxyproline content is an important indicator of lung fibrosis. In this study, no significant differences in the hydroxyproline content of the four treatment ... wasinduced by an intratracheal administration of silica dust,resulting in varying degrees of fibrotic silicosis [15]. Fol-lowing silica-induced lung injury, AMs were stimulated and they secreted...
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Báo cáo y học: "An unusual case of gout in the wrist: the importance of monitoring medication dosage and interaction. A case report"
... occur in any joint including the ankle, knee, hand, wrist, elbow,sacroiliac joint and other joints of the spine, howevermost commonly occurs in the lower extremity. In thiscase, although the ... asfrequently as they have been in the past due to better con-trol of the disease.Competing interests The author(s) declare that they have no competing inter-ests.Authors' contributionsCLJ and ... carpal-metacarpal jointat the base of the thumb. The report stated that the radio-graphs were otherwise normal. The patient's symptoms worsened with increased pain and swelling over the next few days....
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Báo cáo y học: "Incidence of Ocular Zoonoses referred to the Inflammatory and Autoimmune Ocular Diseases Service of the University of Parma - Italy"
... mountains with woods in the South and floody plains in the North. The Po river runs through a fertile plain where world famous food and wines are produced. Green is undoubtedly one of the dominant ... wide. The mountains of the Appennine range divide Parma Province from Tuscany and from Ligury, and Po river flows through its territory. The territory of Parma Province presents two types of ... unknown. In Italy, Lyme disease has been subject to mandatory notification since 1990, but there is likely an underestimation of the real prevalence. There are 400-900 new cases/year in Italy and...
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Báo cáo y học: "Adrenal suppression: A practical guide to the screening and management of this under-recognized complication of inhaled corticosteroid therapy" pptx
... itdissolves into the pulmonary lining and bind s to intra-cellular corticosteroid receptors. The re mainder of the drug that does not get absorbed into the lung (40-90%)is deposited into the mouth and ... the patient’s symptoms.TestingSeveral endocrine tests have been used for the screening and diagnosis of AS. The insulin-induced hypoglycemiatest (IIHT) was once considered the g old standard for the ... metabolites (des-ciclesonide and 17-monopropionate, respectively) by enzymes located in the pulmonary epithelium [53,59] . Because prodrugs areinactive until they reach the lung, they are believed tobe...
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Báo cáo y học: "Biology of recently discovered cytokines: Discerning the pro- and anti-inflammatory properties of interleukin-27" pptx
... immuneresponses and high serum levels of inflammatorycytokines [43]. In these infectious diseases, innateinvolvement promotes the secretion of IL-12 bymacrophages and DCs and thereby creates a highlypolarizing, ... response toinfection. Nonetheless, these findings indicate that IL-27 isgenerated in response to various inflammatory stimuli and imply a role for this cytokine in the regulation of infection-induced ... is in the regulation of immuneprocesses.Interleukin-27 can promote type Iinflammatory responsesIL-6/IL-12 family cytokines play key roles in the generation and regulation of inflammatory responses...
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... nitrotyro-sine. Nitrotyrosine was present both within chondrocytes and in the cartilage matrix, and was seen mainly in the moresuperficial regions. The degree of immunostaining for nitro-tyrosine ... stress induces telomere instability and dysfunction in chondrocytes, subsequently resulting in cartilage ageing and the development of OA through amechanism involving the acceleration of chondrocytesenescence. ... a tendency to maintain the chondrocyte telomere length and proteoglycan remaining in the cartilage explants, suggesting that oxidative stress induceschondrocyte telomere instability and catabolic...
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Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx
... backdrop the paper byFrey and colleagues represents only a minor blink of an eye in the vast Treg literature, but Frey and colleagues introduce aprovocative ‘spin’ to their results as they question ... significantly different. Frey and colleagues alsomonitored the ‘homing’ of the CD4+CD25+Treg and detected an accumulation in the inflamed joints, thusexcluding the possibility that the lack of therapeutic ... IPEX(immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome) [4] or scurfy mice [5] or by means ofdepletion with anti-CD25 monoclonal antibodies in animalmodels, favours the initiation...
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Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt
... pattern ofskin, renal and gastrointestinal pathology. The emergence ofeffective and conveniently administered therapy for PAHincreases the importance of diagnosis and monitoring of thiscomplication. ... is characterised bydecreased production of the vasodilators nitric oxide and prostacyclin, and by enhanced release of endothelin-1. Endothelial cell dysfunction influences the behaviour ofvascular ... at1 year and 2 years of 96% and 89% compared withViewpointCold hands — strained heart? Advances in the management ofRaynaud’s phenomenon and pulmonary hypertensionFrances C HallUniversity...
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