Báo cáo y học: "Death to sepsis: targeting apoptosis pathways in sepsis" ppt

... rheumatologist answered a questionnaire inquiring about the initial symptoms as reported by the patient (type of initial joint symptoms, localization and distribution of initial joint symptoms, ... article Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis Annette HM van der Helm-van Mil, Kirsten N Verpoort, Ferdinand...

Ngày tải lên: 09/08/2014, 06:23

... angiotensin-(1-7), its receptor Mas and the angiotensin-converting enzyme type 2 are expressed in the human endothelium. Reprod Sci 20 09, 16 :24 7 -25 6. 2. Ingelfinger JR: Angiotensin-converting enzyme ... Chem 20 02, 27 7:14838-14843. Additional file 1 Inhibition of the enzyme activity by an ACE2 inhibi- tor. By preincubation with DX600 for 30 minutes, the enzyme act...

Ngày tải lên: 12/08/2014, 12:20

... to the medulla for medullary glycoly- sis and energy production. A similar recycling system may operate in the brain between neurons and astrocytes, and in the testis between Sertoli cells and ... cortico-medullary glucose lactate recycling system. The medulla consumes glucose (glycolysis) and generates lactate. The cortex takes up lactate to oxidize it for energy prod...

Ngày tải lên: 12/08/2014, 18:21

... among body tissues. In different conditions, the rate of lactate synthesis is depen- dent on the activity of the glycolytic pathway relative to the oxidative capacity of the pyruvate dehydrogenase ... statistically significant rates of substrate exchange across the lung in most circumstances. Lung lactate synthesis and release Virtually all tissues can synthesize or utilize...

Ngày tải lên: 12/08/2014, 18:21

... respiratory distress syndrome; PEEP = positive end-expiratory pressure. Critical Care February 2005 Vol 9 No 1 Lapinsky and Mehta Introduction Ventilatory management protocols for acute respiratory distress ... respiratory distress syndrome (ARDS), the lung comprises areas of aeration and areas of alveolar collapse, the latter producing intrapulmonary shunt and hypoxemia. The currently...

Ngày tải lên: 12/08/2014, 20:20

... Ultimately, it may be the responses of monocytes that have already extravasated from the blood into the tissues that is most relevant to the outcome of sepsis, and this was not measured in the study. Given ... study. Given these points, it is too soon to say with certainty that increased early monocyte apoptosis confers a survival advantage in the context of sepsis. Howe...

Ngày tải lên: 12/08/2014, 23:24

... (wounds, surgery, and insertion of indwelling intravascular and urinary catheters). The gastrointestinal tract, the skin and the urogenital tract are the main portals of entry for Candida infections. ... [18]. In ICU patients, the most common types of Candida infections are bloodstream infections, catheter-related infec- tions, intra-abdominal infections and urinary trac...

Ngày tải lên: 13/08/2014, 08:21

... pro- inflammatory and anti-inflammatory mediators at the immune cell level (intracellular cytokine staining, cytokine secretion assay) and cytokine gene expression via array technology may demonstrate ... the redundancy in the inflammatory pathways. Other pathways and cytokines may activate and/or inhibit the system at the same point, and different mediators may function as co- determinants...

Ngày tải lên: 13/08/2014, 11:22

... study results has the advantage of using evidence already subjected to peer Review Bench-to-bedside review: Avoiding pitfalls in critical care meta-analysis — funnel plots, risk estimates, types ... prospective meta-analysis in the planning of any clinical trial. Reporting of meta-analysis Even if appropriately conducted, a meta-analysis must be a...

Ngày tải lên: 13/08/2014, 11:22

... decreased intrinsic muscle function. Increased energy demands The energy needs of the ventilatory system are determined by the tension produced by the respiratory muscles per minute. Normally, expiration ... factors involved in increased ventilatory drive. Cytokines, endotoxin (LPS) and acidaemia produce an initial increase in the drive to breathe. Demands on the ventilatory muscles...

Ngày tải lên: 13/08/2014, 11:23

... leading to diminished paracellular permeability [65]. Summary In the mature vessel, Ang-1 acts as a paracrine signal to maintain a quiescent status quo, whereas Ang-2 induces or facilitates an ... WPBs in an autocrine and paracrine fashion upon stimulation by various inflammatory agents. Ang-2 acts as an antagonist of Ang-1, stops Tie2 signalling, and sensitizes endothelium to inflam...

Ngày tải lên: 13/08/2014, 11:23

... decrease endotoxin-induced TNF synthesis in cultured cardiac myocytes by inhibiting L-type calcium channel-depen- dent ERK signaling, suggesting nNOS might modulate inflammatory signaling [9]. On ... = inducible nitric oxide synthase (NOS2); L-NMMA = N G -methyl-L-arginine; NF = nuclear factor; nNOS = neuronal nitric oxide synthase (NOS1); NO = nitric oxide; NOS = nitric oxide...

Ngày tải lên: 13/08/2014, 11:23

... loss in the critically ill patient. Importantly, Review Bench -to- bedside review: Mobilizing patients in the intensive care unit – from pathophysiology to clinical trials Alex D Truong 1 , Eddy Fan 1 , ... anti-inflam- matory cytokines during moderate exercise may play an important role in muscle preservation and protection. Physical therapy in the inte...

Ngày tải lên: 13/08/2014, 16:20

... generated by the coagulation process, the fibrinolytic system degrades fibrin by its key enzyme, plasmin. Plasmin formation from plasminogen is mainly activated by tissue plasminogen activator and inhibited ... G s proteins and increased inhibitory activity of G i proteins [38]. The sustained adrenergic stimulation per se may trigger cyto- kine production by cardiomyocytes [39]. From another...

Ngày tải lên: 13/08/2014, 18:22

... clinically relevant model) is certainly intriguing and provides supportive evidence that targeting the apoptosis pathway may represent a novel approach to the management of sepsis in the clinical ... cells undergoing necrotic death. Apoptosis is classically triggered via two signaling pathways, the intrinsic pathway (also known as the mitochondrial pathway) and the extrinsic pathw...

Ngày tải lên: 13/08/2014, 19:20