Báo cáo y học: "Mortality in sepsis versus non-sepsis induced acute lung injury" doc

... purposes) tional study is the only way in which we can evaluate the poten- tial independent mortality effects of sepsis- induced versus non -sepsis- induced ALI in humans. In this prospective study, we adjusted ... 5 Research Mortality in sepsis versus non -sepsis induced acute lung injury Jonathan E Sevransky 1 , Gregory S Martin 2 , Carl Shanholtz 3 , Pedro A Mende...

Ngày tải lên: 13/08/2014, 19:20

... of acute kidney injury. • In the ICU, urinary cystatin C is independently diag- nostic of sepsis. • In the ICU, urinary cystatin C predicts AKI in the presence of sepsis. • In the ICU, urinary ... median (interquartile range). AKI, acute kidney injury on admission to intensive care; uCysC, urinary cystatin C; uCr, urinary creatinine; pCysC, plasma cystatin C; pCr, plasma crea...

Ngày tải lên: 13/08/2014, 20:22

... 2-year mortality of 36 [6] to 49% [5]. Several studies have been conducted in order to identify the risk factors of mortality in COPD and there is a con- comitant increasing interest in modifying ... several things that are thought to be important in patients with COPD that there was no information on in the current study: For instance, we had no information on body mass index, phys...

Ngày tải lên: 12/08/2014, 16:20

... be explained in several ways. First, the interventions do not affect outcome. Certainly, there is mounting evidence that some of the studied interventions, such as application of the pulmonary artery ... outcome. Second, any beneficial effects are offset by unwanted side effects. For example, better titration of care secondary to information gained by pulmonary artery catheter use may be of...

Ngày tải lên: 12/08/2014, 19:22

... Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; Euro- pean Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; ... Normoglycaemia in Intensive care Evaluation and Survival Using Glucose Algorithm; SSC = Surviving Sepsis Campaign; VISEP = Efficacy of Volume Substitution and Insulin therapy in Severe Se...

Ngày tải lên: 13/08/2014, 11:22

... Since leptin apparently inhibits an excessive or harmful lipopolysaccharide -induced in ammatory reaction to or prevents TNFα -induced lethality in sepsis [13], it would have been interesting ... obvious choice as sepsis markers, since cytokines are key mediators of the in ammatory response to sepsis. Leptin, a hormone mainly generated by adipocytes, acts centrally in the...

Ngày tải lên: 13/08/2014, 20:21

... to citrullinated peptides in RA patients. Further studies [23,24] focussed on an involvement of peptidylarginine deiminases citrullinating enzymes (encoded by PADI genes). In a Japanese case-control linkage ... antigens by enzymatic activity (deiminases), and subsequent immune-mediated destruction of the synovium [9]. Regulation of peptidyl arginine deiminase (PADI) activity appears also...

Ngày tải lên: 09/08/2014, 06:22

... effective in controlling the symptoms of acute gout, but indomethacin was asso- ciated with significantly greater toxicity than a short course of oral steroids, mainly because of the gastrointestinal ... treatment of hyperuricemia. In acute gout, the understanding of how MSU crystals trigger the inflammatory response indicates that IL-1β may be a new target for acute gout therapy. B...

Ngày tải lên: 09/08/2014, 13:22

... mechanism underlying these acute inflammatory events involves activation of specific signaling pathways such as MAPK (ERK1/2) and NF κB, leading to the release of proinflammatory cytokines. One of ... NHBEs exposed to CSC also showed an increase in nuclear stain- ing of phosphorylated I κB as detected by immunocyto- chemical staining using an antibody to phosphorylated I κB (Fig. 4B). Eff...

Ngày tải lên: 12/08/2014, 18:20

... in Acute Renal Disease (PICARD) study Abstract Introduction: Serum creatinine concentration (sCr) is the marker used for diagnosing and staging acute kidney injury (AKI) in the RIFLE and AKIN ... having reached a percentage change in sCr one day earlier. The masking of AKI severity by volume expansion may be especially problematic in settings where the sCr is rising relatively sl...

Ngày tải lên: 13/08/2014, 20:22