Báo cáo y học: "Sedation improves early outcome in severely septic Sprague Dawley rats" potx

... Kellum JA, Kong L, Fink MP, Weissfeld LA, Yealy DM, Pinsky MR, Fine J, Krichevsky A, Delude RL, Angus DC, GenIMS Investigators: Understanding the inflammatory cytokine response in pneu- monia and ... clearance by the innate immune system. The sympatholytic effects of α 2 adrenoceptor agonists may be useful as sympatholysis has been shown to improve outcome in septic animals [30]. Fin...

Ngày tải lên: 13/08/2014, 18:22

... diseases involving airway obstruction, there have been many studies performed in both animals and humans exam- ining its effectiveness [10–16]. Although heliox has been used safely for many years in ... clini- cally increase resistance to gas flow in small infants. A 15% difference in pulmonary function between the lung receiving heliox and the lung receiving nitrox (control) was pros...

Ngày tải lên: 12/08/2014, 18:20

... spent most of the time in light sleep, arousals easily resulted in awakenings and thereby in lower arousal index than previously reported in healthy elderly people[51] or in patients with COPD[52,53]. ... and oxygenation during sleep. Hypoxemia and hypercapnia during sleep herald respira- tory insufficiency. Many studies have investigated effects of progestins on breathing in awak...

Ngày tải lên: 12/08/2014, 18:21

... early hypothermia is likely to be more effective than delayed hypothermia. In a rat model, delays of 15 min and 30 min preserved the beneficial effect of hypothermia, but with delays of 45 min there ... shock protein-70 in the hippocampus are blunted by hypothermia [17]. Additionally, arachidonic acid products may be involved in an inflammatory cascade, affecting cell survival. In g...

Ngày tải lên: 12/08/2014, 19:21

... Rothen 4 1 Department of Intensive Care Medicine, Royal North Shore Hospital of Sydney, University of Sydney, St Leonards, 2065 NSW, Australia 2 Department of Internal Medicine, Inselspital, Bern University Hospital ... confidence interval) Contingency coefficient P value Renal replacement therapy during ICU stay (yes/no) 13.38 9.71 (2.40 to 39.33) 0.36 0.001 Mechanical ventilation during IC...

Ngày tải lên: 13/08/2014, 11:22

... HDPs representing different classes for inhibition of early, Env-independent steps in the HIV replication cycle. A lentiviral vector-based screening assay was used to determine the inhibitory effect ... observed. Specific inhibitory effects of Protegrin-1 were confirmed for wild type HIV-1. Conclusion: Although Protegrin-1 apparently inhibits an early step in the HIV-replication cycle,...

Ngày tải lên: 13/08/2014, 13:20

... therapy, a key element and unifying feature is the manifestation of car- diovascular dysfunction. Although the underlying cause of death in septic shock is often multifactorial, refractory hypotension ... M, Yip GW, Wang AY, Zhang Y, Ho PY, Tse MK, Yu CM, Sanderson JE: Tissue Doppler imaging provides incremental prognostic value in patients with systemic hypertension and left ventricul...

Ngày tải lên: 13/08/2014, 20:21

... defined as: increase in serum creatinine of ≥26.4 μmol/l (150 to 200% of baseline) or urine output of <0.5 ml/kg/h for >6 h. RIFLE criteria Injury is defined as: increase in serum creatinine to ... mislead- ing result. The SAFE (Saline versus Albumin Fluid Eva- luation) Study Investigators recently published a subgroup analysis only reporting data from the first seven days [18]. In...

Ngày tải lên: 14/08/2014, 08:21

... demonstrated in the analysis of the role of IFN-γ in models of autoimmunity. Early attempts to define the role of IFN-γ in autoimmunity by the adminis- tration of IFN-γ or neutralizing antibodies ... disease [14]. Early attempts to define the role of IFN-γ in CIA by the administration of IFN-γ or neutralizing antibodies specific for IFN-γ yielded conflicting results [15–19], proba...

Ngày tải lên: 09/08/2014, 06:22

... pathway. This is supported by recent findings demonstrating TNFα-independent IL-7-driven inflammatory and bone-destructive activity [6,7]. IL-7 is also able to regulate joint pathology by T cell-driven immune ... Maki K, Ikuta K, Ito M, Suda T: Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: similarity to estrogen deficiency. Proc Natl Acad...

Ngày tải lên: 09/08/2014, 10:23