Báo cáo y học: "Cell death in sepsis: a matter of how, when, and where" potx
Báo cáo y học: "Cell death in sepsis: a matter of how, when, and where" potx
... exacerbate liver injury [9]. In addition to apoptosis, certain caspases, such as caspase-1,are involved in cytokine maturation by proteolytically proces-sing the inactive precursors of interleukin ... not apoptotic cells, is systemically elevated in human sepsis and functions as a mediator of endotoxinlethality in mice [12].Intense research has recently delineated the signaling path-way of ... survivalbut rather lead to alternative pathways of cell death. Indeed,apoptosis may even be protective, by obviating the potential of injured cells to necrosis and further propagating theinflammatory...
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Báo cáo y học: "Cough quality in children: a comparison of subjective vs. bronchoscopic findings" doc
... for citation purposes)present. Inter-rater clinician agreement for cough qualities of dry/wet and brassy/non brassy was good.Accuracy and reliability of symptoms are important in clinical and ... drycough as determined by clinicians and parents has goodclinical validity as it has good agreement with, and relatesto, quantification of airway secretions. However as mini-mal amount of ... pre-determined criteria and graded (1 to 6). Kappa (K) statistics was used for agreement, and inter-rater and intra-rater agreement examined on digitally recorded cough. A receiver operating characteristic...
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Báo cáo khoa học: "Age Prediction in Blogs: A Study of Style, Content, and Online Behavior in Pre- and Post-Social Media Generations" ppt
... in- terests since they are not always available.770age and gender. In International AAAI Confer-ence on Weblogs and Social Media.Mark Hall, Eibe Frank, Geoffrey Holmes, BernhardPfahringer, Peter ... Kumar, Jasmine Novak, Prabhakar Raghavan, and Andrew Tomkins. 2004. Structure and evolu-tion of blogspace. Commun. ACM, 47:35–39, De-cember.Amanda Lenhart, Kristen Purcell, Aaron Smith, and Kathryn ... al.’s approach usingthe same data and have a 4% increase in accu-racy. However, the paper is lacking details and it is entirely unclear how they were able to dothis with fewer features than...
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Báo cáo y học: "eening the human exome: a comparison of whole genome and whole transcriptome sequencing" pot
... coverage RNA-Seq in the same individual. This comparison allowed us to directly evaluate the sensitivity and specificity of RNA-Seq in identifying coding variants, and to evaluate how key parameters ... Ensembl's transcript library arehypothetical and not confirmed to be expressed. A list of core exons as defined by the Affymetrix (Santa Clara,California, USA) Human Exon 1.0 ST Array was utilizedto ... data for a more easily accessible tissue suchas skin for this exon array publicly available; however, onecan extrapolate that adding cDNA from almost any tissuewould be similarly beneficial...
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Báo cáo y học: "Cell death serum biomarkers are early predictors for survival in severe septic patients with hepatic dysfunction" pptx
... key mediators of apoptosis are caspases, leading tothe caspase-dependent pathway of apoptotic cell death. Cas-pases are intracellular cysteine proteases that cleave varioussubstrates including ... cell death involves measuring intracellu-lar components (eg, in the liver, alanine and aspartate ami-notransferases; in the heart, creatine kinase and troponin T),which are released into the ... mode of cell death in critically ill patients with sepsis by achieving a bal-ance between systemic oxygen delivery and oxygen demand.Conclusion In summary, we have demonstrated that in healthy...
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Báo cáo y học: "Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis" pps
... existing evidence of an involvement of TLRs in thepathogenesis of RA and other inflammatory diseases, a greatdeal of interest exists in understanding the molecular basis of the signalling pathways ... macrophages may have altered signalling patternswhen compared to other cell types, and IL-10 may have bothanti- and pro-inflammatory functions in RA. In macrophages the principal intracellular ... superfamily, the structuralbasis of this interaction is unclear at this stage. Activation of NF-κB and MAPK pathways lead to transcription and mRNAstabilisation of pro-inflammatory molecules; transcriptionfactors...
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Báo cáo y học: " Paraneoplastic limbic encephalitis as a cause of new onset of seizures in a patient with non-small cell lung carcinoma: a case report" potx
... characterized' paraneoplastic antibodies.b) CSF analysis assists in making the diagnosis of PLE bydetecting inflammatory abnormalities (lymphocytic pleo-cytosis, elevated proteins, intrathecal ... brain magnetic resonance imaging findings and the results of the brain biopsy, weconcluded that our patient had a 'definite' diagnosis of paraneoplastic limbic encephalitis and he was ... characterized'paraneoplastic antibodies [2].PEM is characterized pathologically by neuronal loss and inflammatory infiltrates in particular areas of the nervoussystem. The location and severity of the neuronal...
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Báo cáo y học: "Coagulation cascade in sepsis: getting from bench to bedside" pot
... dosing of potentialnew therapies.Altering the intrinsic balance of coagulation and inflammation: detrimental consequences A safe assumption is that any new therapies that alter theintrinsic ... or synthetic analogues of coagulation cascade components (e.g. protein C, thrombin, and factor VIIa or Xa), coagulation inhibitors (e.g. heparin oranalogues), or agonists or antagonists of the ... detrimental effects is theadministration of protein C resulting in undesirablehaemorrhage [3]. This example illustrates that a broaderknowledge of the impact of altering the coagulation/inflammatory...
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Báo cáo y học: "Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients" pptx
... forearly risk stratification and prediction of inhospital and overallmorbidity and mortality in a range of conditions includingstroke [6], myocardial infarction [11], cancer [8] and trauma[12]. ... local research/ethics commit-tee as this was an observational study looking at plasma DNA, a new variable measured from blood samples that were takenas part of standard clinical practice. All ... demonstrate that plasma DNA may be a useful prog-nostic marker of mortality and sepsis in intensive care patients.Although a recent study has demonstrated that plasma DNAlevels were higher in patients...
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