Báo cáo y học: "Early stress exposure: Concepts, findings, and implications, with particular emphasis on attachment disturbances" pptx

... for citation purposes)Child and Adolescent Psychiatry and Mental HealthOpen AccessReviewEarly stress exposure: Concepts, findings, and implications, with particular emphasis on attachment ... Psychi-atry 1988, 145:1-10.6. Belsky J, Fearon RM: Early attachment security, subsequentmaternal sensitivity, and later child development: does con-tinuity in development depend upon continuity ... caseof attachment disturbances, one good context for studying early risk and intervention, sizablequestions remain about conceptual models and assessment practices.Conclusion: Implications of...

Báo cáo y học: " Early atherosclerosis in systemic sclerosis and its relation to disease or traditional risk factors" pdf

... history of macrovascularevents compared with none in the control group.Patients with SSc had a median disease duration of 6 years and had experienced Raynaud phenomenon for almost 11years. ... patients with an IMT of greater than 1.10 mm, onepatient had a history of a cerebrovascular accident and onepatient was known to have left ventricular dysfunction proba-bly caused by coronary artery ... this study, weassessed signs of early atherosclerosis by measuring intima-media thickness (IMT) of the common carotid artery (CCA) inpatients with SSc and healthy controls. In addition, we relatedthe...

Báo cáo y học: "Early results of coronary artery bypass grafting with coronary endarterectomy for severe coronary artery disease" ppsx

... atherosclerosis.MethodsOne-hundred and four patients with diffuse coronaryartery disease underwent coronary artery bypass grafting(CABG) with adjunctive coronary endarterectomy (CE) ofat least one artery in ... 75:865-9.11. Christenson JT, Simonet F, Schmuziger M: Extensive endarterec-tomy of the left anterior descending coronary artery com-bined with coronary artery bypass grafting. Coronary ArteryDisease 1995, ... efficiency of coronaryendarterectomy (CE), it is still used as an adjunct to coronary artery bypass grafting (CABG). Thisis particularly true in patients with endstage coronary artery disease....

Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" ppt

... CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes. Arch Biochem Biophys 2010, 498:62-73.21. ... throughaltering their acetylation and methylation status and thereby regulating gene expression [8]. In addition, Mi-2possesses an ATPase-dependant nucleosome remodellingcapacity and mSin3a can recruit ... transcriptionally closed con-formation [1,16].HDAC-2 function is impaired by oxidative stress whichmay be critical in the development of the uncontrolledchronic and relatively glucocorticoid...

Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" pdf

... CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes. Arch Biochem Biophys 2010, 498:62-73.21. ... Mi-2α and mSin3a and increased protein expression of Mi2β may lead toaltered gene repression. This in turn may have importantimplications in the development of chronic inflammation and reduction ... transcrip-tional machinery and the chromatin structure throughaltering their acetylation and methylation status and thereby regulating gene expression [8]. In addition, Mi-2possesses an ATPase-dependant...

Báo cáo y học: "Hyperosmotic stress enhances cytokine production and decreases phagocytosis in vitro" ppsx

... significantly reduced with increasingconcentrations of glucose and mannitol.Conclusion Hyperglycemia may lead to inflammation byenhancing cytokine production via the direct effects ofhyperosmotic stress. ... and mannitolsignificantly enhanced LPS-induced cytokine production. Insulinalone did not alter cytokine production and had only a minorinfluence in combination with glucose. Phagocytosis and oxidative ... drugs. Hyperglycemia is an independ-ent risk factor for increased morbidity and mortality in criticallyill patients with a variety of conditions. After myocardial infarc-tion, hyperglycemia is...

Báo cáo y học: " Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection" docx

... CD4-lymphocytes,CD8-lymphocytes and B-lymphocytes decrease; inintraabdominal infections absolute counts of CD8-lym-phocytes and the rate of apoptosis of CD8-lymphocytesdecrease; in primary bacteremia ... of bronchoalveolar lavage and or tracheobronchial secretions;APACHE: acute physiology and chronic health evaluation; CAP: community-acquired pneumonia; COPD: chronic obstructive pulmonary disease; ... amount of cytokines as monocytes of the non-septic host. This phenomenon is called immunoparalysis and it may be accompanied by cellular apoptosis. In arecent study by our group, monocytes were...

Báo cáo Y học: Pyruvate decarboxylase from Kluyveromyces lactis An enzyme with an extraordinary substrate activation behaviour pptx

... koenig@biochemtech.uni-halle.deAbbreviations: PDC, pyruvate decarboxylase (2-oxo acid carboxylyase, EC 4.1.1.1); ByPDC, pyruvate decarboxylase from brewer’syeast; KlPDC, pyruvate decarboxylase from Kluyveromyces lactis;PsPDC, pyruvate ... catalyses the nonoxidative decarboxylation of pyruvateto acetaldehyde and carbon dioxide. Thiamine diphos-phate (TDP) and Mg2+are both required as cofactors inthis reaction. In yeast and ... microscopic rateconstants; pyruvamideThe cytosolic pyruvate decarboxylase (PDC) is a keyenzyme at the branching point of alcoholic fermentation and respiration in yeast, some bacteria and plant seeds.It...

Báo cáo y học: "Closure of the NCBI SRA and implications for the long-term future of genomics data storage" doc

... http://img.jgi.doe.gov/cgi-bin/m/main.cgi), Community Cyberinfrastructure for Advanced Microbial Ecology Research and Analysis (CAMERA, http://camera.calit2.net/) and Visualization and Analysis of Microbial Popu-lation Structures ... University of Maryland, Mark Gerstein (MG) from Yale University and Rob Knight (RK) from the University of Colorado).1. Why did the SRA close? How widely used by the community was it?DL: NCBI ... we rely on it maybe more than others. We download data reasonably frequently, but because of the size of the datasets we try not to do it too often.RK: e SRA was widely disliked by a lot...

Báo cáo y học: " Decrease of vitamin D concentration in patients with HIV infection on a non nucleoside reverse transcriptase inhibitor-containing regimen" doc

... deficiency was common before HAART, the frequency of plasma 25-(OH)D concentrationsbelow 20 ng/ml and 30 below ng/ml was 43.7% and 70.1% respectively. After 12 months on HAART, the frequencyincreased ... hydro-xylations by cytochromes P450 [9]. Both 1,25-(OH)2D and 25-(OH)D are catabolized by the cytochromeCYP24 [9]. In target cells such as immune cells,1,25-(OH)2D is converted locally ... A:Vitamin D and calcium supplements reverse the secondaryhyperparathyroidism that commonly occurs in HIV patients on TDFcontaining HAART. 15th Annual Conference of the British HIV Association,Liverpool,...

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