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Báo cáo y học: "because I am something special" or "I think I will be something like a guinea pig": information and assent of legal minors in clinical trials – assessment of understanding, appreciation and reasoning'''''''' pot

Báo cáo y học:

Báo cáo y học: "because I am something special" or "I think I will be something like a guinea pig": information and assent of legal minors in clinical trials assessment of understanding, appreciation and reasoning'''' pot

... something like a guinea pig": information and assent of legal minors in clinical trials assessment of understanding, appreciation and reasoningMichael Koelch*, Hanneke Singer, Anja Prestel, ... feasibility of providing information about clinical tri-als according to informed consent criteria and the under-standing of information related to clinical trials. The appreciation of children and adolescents ... capacities for understanding, appreciation and reasoning of legal minors with psychiatric disorders and their parents and theircompetence to consent or assent to participation in clinical trials. ...
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Báo cáo y học: "XeNA: Capecitabine Plus Docetaxel, With or Without Trastuzumab, as Preoperative Therapy for Early Breast Cancer" pps

... Evaluation Criteria for Solid Tumors (RECIST) for palpable measurable disease. Key exclusion criteria included inflammatory breast cancer, clinically sig-nificant cardiac disease, and inadequate ... the clinical benefit of docetaxel plus cape-citabine in patients with breast cancer [23]. In a randomized trial in patients with MBC, the combination of capecitabine 1250 mg/m2 twice daily ... on clinical experience and findings from retrospective analyses of dose modification in this trial, lower doses of capecitabine and docetaxel are typically used in this setting and do not appear...
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Báo cáo y học: "Administering the MADRS by telephone or face-to-face: a validity study" docx

... prelimi-nary results showed that only very little variance was dueto interviewer variation, indicating that the reliability of the interviewers was high.Third and finally, the in- person interview ... administra-tion may have several advantages. It (a) can include alloriginal items, (b) preserves the characteristic of a clinical interview, and (c) is less costly and time-consuming than in- person ... than in- person administration. Previous studies have exam-ined the comparability of face-to-face and telephone-administered interviews for obtaining data on health sta-tus or psychiatric symptoms...
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Báo cáo y học: "Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis" pptx

... manuscript. MTparticipated in frequency analysis of NKT cells. KB partici-pated in reactivity assays. PG provided clinical material. VS and JR critically revised the manuscript. PS coordinated ... 1998,188:1521-1528.6. Nieda M, Nicol A, Koezuka Y, Kikuchi A, Takahashi T, Nakamura H,Furukawa H, Yabe T, Ishikawa Y, Tadokoro K, et al.: Activation of human Valpha24NKT cells by alpha-glycosylceramide in a CD1d-restricted ... chemok-ines rapidly is thought to underlie their regulatory function in a variety of diseases, including cancer and autoimmunity [4].Although the natural ligand of NKT cells remains to be eluci-dated,...
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Báo cáo y học: "Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control study" pdf

... USA2Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA3Mayo Alliance for Clinical Trials and the Mayo Clinic, Rochester, MN, USA4Division of Biostatistics, Mayo Clinic, ... scleritis. Use of corticosteroids and disease modifying therapy was fairly typi-cal of patients with long-standing RA.Coronary artery involvementThere was a statistically significant difference ... inter-pretation and participated in study design. JJG participated in study design, interpretation of data and manuscript prepara-tion. CMW conceived the study, participated in its design and coordination...
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Báo cáo y học: "Prolonged, granulocyte–macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha" doc

... colony-stimulating factor, CCL2 and CXCL8 failed to inhibit neutrophil survival any further.Using an inhibitor of the phosphatidylinositol-3-kinase signal-ling pathway (Ly294002) and an inhibitor ... patterns in inflammatory arthritis. Proc Natl Acad Sci USA 1994,91:8562-8566.3. Morita Y, Yamamura M, Kawashima M, Harada S, Tsuji K, ShibuyaK, Maruyama K, Makino H: Flow cytometric single-cell analysis of ... work is properly cited.AbstractIntroduction A surprising feature of the inflammatory infiltrate in rheumatoid arthritis is the accumulation of neutrophils withinsynovial fluid and at the pannus...
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Báo cáo y học: "Failure to respond to endogenous or exogenous melatonin may cause " pdf

... Relative humidity was4 0–6 5%, and temperature was maintained at 23 ± 3°C.Due to bright light's ability to cause retinal damage toalbino rats, light intensity was maintained between 100 and ... ganglion in the spinalcord, and eventually to the pineal gland, which releasesthe indoleamine hormone melatonin [5]. Pinealoctyeswithin the pineal gland convert tryptophan into 5-hydrox-ytryptamine ... recorded.Data Analysis In statistical testing of data on aMT6s, the data from eachstrain was analyzed independently for nocturnally ele-vated aMT6s excretion and for differences in excretionbetween...
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Báo cáo y học: "Surgical treatment for pulmonary metastases from esophageal carcinoma after definitive chemoradiotherapy: Experience from a single institution" doc

... esophageal carcinoma to eluci-date its efficacy. A previous report indicated that solitary pulmonarymetastasis from esophageal carcinoma was a favorableindicator for surgical treatment [6]. In ... Kawamura M, Sato T, Nakagawa K, Nakajima J, Yoshino I, Ikeda N,Horio H, Akiyama H, Kobayashi K: Disease-free interval length correlates toprognosis of patients who underwent metastasectomy for ... surgical treatment forpulmonary metastases from esophageal carcinoma. A major characteristic of this article is that the primarytreatment for esophageal carcinoma was confined todefinitive...
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Báo cáo y học: "Effective cardiac resynchronization therapy for an adolescent patient with dilated cardiomyopathy seven years after mitral valve replacement and septal anterior ventricular exclusio" ppsx

... and a pediatric cardiologist in charge in a pediatricward of Kyoto university hospital. SB is an assistant professor and a pediatriccardiologist in charge in a pediatric ward of Kyoto university ... an attending physician in the pediatric outpa-tient clinic in Kyoto university hospital. TD is an attending physician in the car-diovascular outpatient clinic in Kyoto university hospital. ... university hospital. NY is a graduate student and a pediatric cardiologist in charge in a pediatric ward of Kyoto university hospital. SK is an assistant professor and a pediatric cardiolo-gist in a...
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Báo cáo y học: "Heart echinococcus cyst as an incidental finding: early detection might be life-savin" doc

... Echinococcusgranulosusinfectioninhumans. Cardiac involvement is rare, and early diagnosis and prompt surgical interventio n are critical, with com-plete resection of the germinal layer being of majorimportance for ... 60%, without regional wall motion abnormalities.Coronary angiography revealed normal coronaryarteries.Excision of the cardiac cyst was planned by using cardi-opulmonary bypass and the patient ... gregtsig@hotmail.com1Department of Cardiology, Patras University School of Medicine, Patras,GreeceFull list of author information is available at the end of the articleTsigkas et al. Journal of Cardiothoracic Surgery 2010,...
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