Báo cáo y học: " Regulation (EC) No 1901/2006 on medicinal products for paediatric use & clinical research in vulnerable populations" doc

... publication of information on clinical trials for already authorised medicinal products. The EC published a consultation on a "Draft Guidance on the information concerning paediatric clinical trials ... trials Additionally all guidelines containing recommendation on clinical trials for specific indication have to be carefully scrutinized and updated in respect t...

Ngày tải lên: 13/08/2014, 18:21

... open to anyone interested. The weight loss program consisted of a 500 calo- rie per day dietary restriction in combination with the following: 1. Daily sublingual treatments by vitamin B12 (1,000 ... female: they ranged in age from thirty to sixty-five years old. The lone male was forty years old. Assay methods are described below. Body composition Body composition was measured b...

Ngày tải lên: 25/10/2012, 10:51

... mechanical dyssynchrony. These findings may further explain why patients with normal QRS duration may benefit from cardiac re- synchronization whether or not they have mechanical dyssynchrony under ... dyssynchrony in heart failure patients with normal QRS duration. By characterizing mechanical interventricular dyssynchrony, which was commonly found to be associated with intra-LV dys...

Ngày tải lên: 05/11/2012, 11:32

... structure determination of hA2aR by X-ray or electron crystallography, or infor- mation on the bound ligand conformation obtained by NMR spectroscopy, would assist in the design of subtype speci®c ... saturation and competition binding experiments on puri®ed receptor. Amounts of tritiated antagonist were determined by liquid scintillation counting. Binding data were analysed by nonlinea...

Ngày tải lên: 24/03/2014, 00:21

... cells in chronic rheumatoid synovitis? Arthritis Rheum 1990, 33:768-773. 4. Panayi GS, Lanchbury JS, Kingsley GH: The importance of the T cell in initiating and maintaining the chronic synovitis ... shown in several animal models [25–28]. In addi- tion, we have already demonstrated the presence of IL-12 as a contributory factor in inducing the IFN-γ-dominant T-cell cytokine response...

Ngày tải lên: 09/08/2014, 01:23

... certain inflammatory cytokines (IL-6, IL-1β) and by certain growth factors. Extracellularly, TIMPs inhibit MMP activity by forming high- affinity noncovalent complexes with MMPs. The amino-termi- nal ... fluid was obtained from 21 patients (aged 36 to 88 years) with noninflammatory joint diseases (osteoarthritis, 8 patients; chondrocalcinosis, 2; villonodular synovitis, 1; knee contusion, 4;...

Ngày tải lên: 09/08/2014, 06:23

... targeting cytokines (IL-1, IL-10, or IL-6) and use of agents that interfere with lymphocyte action. Competing interests The authors declare that they have no competing interests. Authors’ information The ... MIP3-α (macrophage inflammatory protein-3α); IP-10 (IFN-inducible protein-10); Mig (monokine induced by IFN-γ); iTac (interferon-inducible T cell chemo-attractant); and adhesion molec...

Ngày tải lên: 09/08/2014, 14:20

... epidemiology of viral infections circulating in the com- munity, and at the same time reveal the occurrence of asymptomatic infections in the population [6]. Conclusions In conclusion, this study - ... (GenBank accession num- bers included in the tree) confirms the presence of HAV strains belonging only to genotype IA. Kokkinos et al. Virology Journal 2010, 7:235 http://www.virologyj....

Ngày tải lên: 12/08/2014, 01:21

... Serotonin trans- porter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hyperten- sion. J Clin Invest 2001, 108(8):1141-1150. 28. Austyn JM, Gordon ... paraffin embedding. Sec- tions 5 μm in thickness were cut and stained with hema- toxylin-phloxine-saffron for examination by light microscopy. In each mouse, a total of 20 to 30 intra...

Ngày tải lên: 12/08/2014, 14:20

... analysis was not per- formed in this study. Pulmonary microvascular and parenchymal injury is pro- duced by mechanical ventilation not only in the pathological lung [8,23,24], but also in the normal ... impairment of oxygenation. HFO may reduce lung injury via the attenuation of pulmonary inflammation. Keywords: adhesion molecule, high frequency oscillatory ventilation, leukocyte, lung...

Ngày tải lên: 12/08/2014, 18:20