Báo cáo y học: " The hyperbolic effect of density and strength of inter beta-cell coupling on islet bursting: a theoretical investigation" ppt

... purposes) Theoretical Biology and Medical ModellingOpen AccessResearch The hyperbolic effect of density and strength of inter beta-cell coupling on islet bursting: a theoretical investigationAparna ... to it, alter-nate between being an irregular hexagonal (IH, the sixsides and internal angles are not all equal) layer, and a reg-ular hexagonal (RH) layer. The edge size decreases eachtime ... The change in intercellular calciumconcentration is given bywhere f is the fraction of free Ca2+ and kCa is the removalrate of Ca2+ in the intracellular space. α is a conversion fac-tor...

Báo cáo y học: "The association between disease activity and NT-proBNP in 238 patients with rheumatoid arthritis: a 10-year longitudinal study" pptx

... patients with RA of less than 4 years in dura-tion longitudinally with comprehensive assessments of clinical and radiographic data at baseline and after 5 and 10 years[15]. The patients had ... N-terminal fragment of the active hormoneBNP, has a longer half-life than the active hormone and is a via-ble biomarker of cardiovascular disease (CVD) [13]. In the healthy heart, the main site of BNP ... interests.Authors' contributionsSAP developed the study, performed the analyses, and drafted the manuscript. KA participated in the development of the study and in the drafting of the manuscript....

Báo cáo y học: "The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanase" docx

... great variability in the response of chondrocytes to the synthesis of ADAMTS-5upon stimulation by cytokines and growth factors under actualconditions [15]. A regulation of the enzyme synthesis ... [31]. The results of a number of studies indicate that the regulatory mechanisms of ADAMTS-4 and ADAMTS-5 gene expression and proteinsynthesis are complex and may vary based on species and cul-ture ... independent.Real-time quantitative PCR analysisExtraction of total RNA from cartilageTotal RNA was extracted directly from the cartilage. The carti-lage from the condyles and the plateaus (0.5–1.0 g) waspooled...

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Báo cáo y học: "The counterintuitive effect of multiple injuries in severity scoring: a simple variable improves the predictive ability of NISS" ppt

... models). A ll the analyses were con-ducted using STATA 10.Because of the observational design of the study and the anonymity of the final database, neither patient con-sent nor approval of ethical ... Hospital, Udine/Regional Health Agency of Emilia-Romagna, Bologna, ItalyFull list of author information is available at the end of the articleDi Bartolomeo et al. Scandinavian Journal of Trauma, ... [5-10].Theroleofmultipleinjuriesinoutcomeprediction and scoring is important because the majority of patients have more than one injury. For example, only38.3% of patients of the American National TraumaData Bank (NTDB) sustained a single...

Báo cáo Y học: The unorthodox histidine kinases BvgS and EvgS are responsive to the oxidation status of a quinone electron carrier ppt

... energy of a cell, and it wasrecently shown that they can bind small ligands such asFAD and ATP [13,29,31]. In fact, mutations in this domainhave been reported which cause either the inactivation ... genusBordetella. The strong link of the master regulator of virulence to basic metabolism of the bacteria suggests thatthis system may have already been used by an ancestor of the pathogenic bacteria. ... ArcAregulates the expression of many genes which are involvedin the adaptation of the bacteria during the switch betweenaerobic and anaerobic growth conditions. The ArcABregulon comprises factors...

Báo cáo y học: "The proinflammatory cytokines IL-1β and TNF-α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway" ppt

... digested by KpnI and Not1.Mice and CIADBA1 mice (The Jackson Laboratory, Bar Harbor, ME, USA)were bred and maintained in accordance with the guidelines of the institutional animal care and use ... hyperprolifer-ation of synovial cells, and bone destruction. Hyperproliferativesynovial fibroblasts play a critical role in the pathogenesis of RA by the following mechanisms: They directly invade bone and ... Erk was analyzed by anti-p-Erk antibody (top panel). The same membrane was reprobed by anti-Erk antibody (bottom panel). (c) p38 activation was analyzed by anti-p-ATF2 antibody (top panel). The...

Báo cáo y học: "The pea aphid genome sequence brings theories of insect defense into question" ppsx

... synthesis of non-essential amino acids [8]. Manual annotation of the pea aphid genome indeed shows that it lacks machinery to synthesize the nine amino acids that are essential to other animals ... into aphid development and their interactions and coevolution with obligate and facultative symbiotic bacteria. Among the studies enabled by the genome project is the charac teri-zation of ... cell walls of Gram-negative and Gram-positive bacteria, and this leads to the activation of the Toll and immuno-deﬁciency/c-Jun N-terminal kinase (JNK) pathways. e recognition of Gram-positive...

Báo cáo y học: "The challenge to verify ceramide’s role of apoptosis induction in human cardiomyocytes a pilot study" doc

... the statistical analysis. MM, FA and TW participated in the experiments and dataevaluation. HA and GZ conceived of the study, and participated in its design and coordination. All authors read ... effect of ceramide and amitryptline on apoptosis in human cardiomyocytes.Percentage of anti-activated caspase-3 ( 3A) and anti-PARP-1cleavage (3B) positive cardiomyocytes. In the treated control ... kinase-c can inhibit translocation of the kinase to the plasma membrane and t herefore inhi-bits its catalytic acti vity. Finally the intrinsic and extrin-sic pathways of apoptosis i nduction...

Báo cáo y học: " The clinical global impression scale and the influence of patient or staff perspective on outcome" doc

... manuscript. AS participated in the analysis and interpretation of the data. MB participated in the design of the study and the statistical analysis. RJ and MP participated in the design of the study and ... coordinated the data acquisition. SG has been involved in drafting and revising the manuscript, and coordinated the study and data acquisition. Allauthors read and approved the final manuscript.Competing ... Germany.2EOS Hospital for Psychotherapy,Münster, Germany.Authors’ contributionsTF contributed to conception and design of the study, conducted the statistical analysis and wrote the manuscript....

Báo cáo y học: " Psychiatric disorder in early adulthood and risk of premature mortality in the 1946 British Birth Cohort" pdf

... forMental Health at the South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King’s College London. Diana Kuh and ImranShah are employed by the UK Medical Research Council.There ... misclassification - these are “snapshots” atone time and may not fully represent the individual’sbackground. Our measures of alcohol consumption and physical health status are taken at age 36 only ... revisedTable 2 Hazard ratios for mortality (36-60 years) by psychiatric disorder at 36 years, obtained from Cox’s proportionalhazards models and based on 3283 men and women and 204 deathsHazard ratios...

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