Báo cáo y học: " The velocity of the arterial pulse wave: a viscous-fluid shock wave in an elastic tube" pot

... are differently glyco- sylated, and that nonglycosylated biglycan and decorin are more abundant in OA cartilage [20]. Changes in glycosylation of the SLRPs, whether by altered synthesis or subsequent Figure ... sulphate and keratan sulphate (KS) substituted proteoglycans (aggrecan) are entrapped. The negatively charged aggrecan glycosaminogly- can side-chains act to create an osmo...

Ngày tải lên: 09/08/2014, 06:23

... function at early and late stages of cancer would be decreasing local cancer cell population, an apparently unsuccessful self-protective mechanism of human body in battling against cancer. Further ... a research grant from the Cancer Research Society of Canada. W. Sun would also like to acknowledge the College of Phar- macy and Nutrition, University of Saskatchewan f...

Ngày tải lên: 25/10/2012, 11:15

... findings of Hwang et al [13]. Acoustic energy decreases gradually as it prop- agates through the intervening tissues. Anatomically the pancreas lies in deep abdomen and is surrounded by many ... was composed of three parts: a firing system located in a degassed water tank, an imaging system consisting of an ultrasound scanner coupled wi t h a sterotaxic localizing...

Ngày tải lên: 25/10/2012, 11:18

... has low lipase activity and a normal esterase activity, displays a substantial conformational change in the substrate-binding site in the C-terminal domain (red arrow). Modeling of the K41 4A ... site in the N-terminal domain of one subunit and the substrate recognition site in the C-terminal domain of the other face each other, thereby bringing together the...

Ngày tải lên: 21/02/2014, 15:20

... used. RESULTS The enzymatic activity and molecular stability of the mutants The catalytic activity and the molecular stability of the mutants were assayed because a change in either of these parameters ... I and IV and the appearance of fragment II in the degradation of the Tyr146!His/Asn147!Ser mutant (panel d) indicated a significant decrease in the rate...

Ngày tải lên: 22/02/2014, 07:20

... in computation. Constraints involving resolved prochiral protons are handled by INDYANA in a manner similar to the original DYANA program in the absence of a stereospecific assign- ment, except that the fixed distances ... to the set of distances. The main advantages of the procedure are simple: the details of the calibration are precisely and unambiguously defi...

Ngày tải lên: 22/02/2014, 07:20

... addition of a flavone (apigenin), of a flavanonol (taxifolin) and of a flavan-3-ol (epicatechin) (Fig. 8) did not alter the EPR spectra of the enzyme indicating the absence of binding to the copper ... difference in temperature, crystal packing and manner of freezing, and the use of different preparations and batches. Nevertheless, EPR spectroscopy and X-ray cryst...

Ngày tải lên: 22/02/2014, 07:20

... is an effective way to explore the nature of the binding site and the process of catalysis for a- amylases. Although the overall structure and the tertiary folding of the polypeptide chains of ... the crystalline state are free or complexed to a substrate- analogue, is a powerful method for mapping the active site of an a- amylase. However, these data can v...

Ngày tải lên: 08/03/2014, 09:20

... with the anti-myc Ig. Besides the 38 kDa band corres- ponding to CCR5-myc-his which is present in lane a, the heavy and light chains of the anti-CD4 Ig (50 and 25 kDa, respectively, lane a) are also ... (Fig. 3A) . CCR5 was quantitatively retained on the column, and could be eluted with imidazole. The protein was unidentifiable by autoradiography in cell lysates, but appear...

Ngày tải lên: 08/03/2014, 09:20

... features can point to an enhanced flexibility or possibly a break in the helix. Structure calculation by a standard DYANA protocol yielded a bundle of 20 structures with satisfactory values of the ... converted into upper distance bounds with the routine CALIBA of the program package DYANA [29]. After discarding redundant and duplicated constraints, the final list incl...

Ngày tải lên: 08/03/2014, 09:20