Báo cáo y học: " The Basic Immune Simulator: An agent-based model to study the interactions between innate and adaptive immunity" doc

... purposes) Theoretical Biology and Medical Modelling Open Access Software The Basic Immune Simulator: An agent-based model to study the interactions between innate and adaptive immunity Virginia ... contributors Abstract Background: We introduce the Basic Immune Simulator (BIS), an agent-based model created to study the interactions between...

Ngày tải lên: 13/08/2014, 16:21

... biosyn- thetic pathways of tetrahydrofolate and tetrahydrobiopterin [3,4]. GTP cyclohydrolase II catalyzes the hydrolytic release of C8 of GTP accompanied by the release of pyrophosphate from the ... Germany; 2 Lehrstuhl fu ¨ r Anorganische und Analytische Chemie, Technische Universita ¨ tMu ¨ nchen, Garching, Germany GTP cyclohydrolase II catalyzes the hydrolytic release of formate...

Ngày tải lên: 23/03/2014, 21:20

... solution. In order to determine the affinity for Ca 21 and the cooperativity of Ca 21 -binding to p26olf, we next analyzed the stoichiometry of Ca 21 -binding to p26olf by flow dialysis in the Tris buffer. ... sequentially, and has a total of four Ca 21 -binding sites (known as EF-hands). In this study, to elucidate the mechanism of Ca 21 -binding to each EF-hand (named...

Ngày tải lên: 24/03/2014, 04:21

... therapy (TFCBT), stress management, other ther- apies (supportive therapy, nondirective counseling, psy- chodynamic therapy, and hypnotherapy), group cognitive behavioral therapy and eye movement ... prognosis [2]. The development of treatments for PTSD is challenging due to the complexity of the symptoms and psychiatric comorbidities. Psychotherapy and pharmacotherapy are th...

Ngày tải lên: 11/08/2014, 17:20

... the extent and nature of disease heterogeneity; the frequency of the high- risk allele and the concomitant attributable risk; the pene- trance of a specific allele; and the ability to define a ... likely to be offset by the need for very large sample sizes and a substantial penalty neces- sary to correct for multiple comparisons. Further limita- tions come from th...

Ngày tải lên: 12/08/2014, 18:20

... example, the T-even coliphage DNA contains not cytosine but 5-hydroxymeth- ylcytosine, and most of the hydroxymethylcytosine resi- dues in these DNAs are glycosylated as well [20]. The genome of the ... and hydroxyl ions in the glycolic and lactic acids monomers of PLGA towards the hydroxyl and hydrogen ions in the N-9 and the REase nanoparti- cles model. The unde...

Ngày tải lên: 13/08/2014, 16:21

... Comparison of the S Arrays and the N Arrays using the BGI japonica annotation. Log 2 (S/N) of the hybridization intensity was calculated for individual models (top) and the mean intensity of all models ... TE models was not assessed. The nonredundant models were further divided into CG, EG and UG models based on their alignment to rice full-length cDNAs and ESTs and...

Ngày tải lên: 14/08/2014, 14:21

... mice and tumor samples and KKL performed array analysis for the confirmation study. Taqman assays were performed by JS. Array CGH data were provided by DGA. The paper was written by DAQ and AB. Received: ... (FIS)/FEDER, MICIIN/plan-E 2009, JCyL (’Biomedicina y Educación’) and CSIC. The funders had no role in study design, data collection and analysis, decision to publi...

Ngày tải lên: 09/08/2014, 22:23

... proximal stenosis of 90% in the circumflex artery and a stenosis of 99% between the proximal and middle part of the right cor- onary artery. The ejection fraction w as normal and the aortic valve was ... University Hospital Alexandroupolis, 68100, Greece. 2 Dpt of Cardiovascular and Thoracic Surgery, University Hospital Goettingen, Germany. 3 Dpt. of Anesthesiology. Univer...

Ngày tải lên: 10/08/2014, 09:22

... be due to a partial and temporally-limited inactivation of JAK/STAT pathway by PTPH1 deletion. Further biochemical analy- sis are necessary to confirm this hypothesis and to under- stand the possible ... contributions The study was devised by CP and VM and carried out by CP. DL performed the behavioral tests (Von Frey, Hargreaves and Catwalk) on PTPH1-WT and KO ani-...

Ngày tải lên: 11/08/2014, 03:20