Báo cáo y học: "Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)" docx

... ABCC9 ABCC8 ABCC10 ABCA7 ABCA1 ABCA4 ABCA2 ABCA3 ABCA13 ABCA12 ABCA10 ABCA9 ABCA6 ABCA5 ABCG4 ABCG1 ABCG2 ABCG8 ABCG5 ABCD2 ABCD1 ABCD3 ABCD4 Theoretical Biology and Medical Modelling ... state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5) Aina W Ravna*, Ingebrigt Sylte and Georg Sager Address...

Ngày tải lên: 13/08/2014, 16:21

... abdominal aorta (IAAA) affects approximately 3% to 10% of the population diagnosed with an abdominal aortic aneurysm [2]. The principal aetiological agents of the disorder include Salmonella, ... patients died [5-7]. Traditionally, treatment of infectious aortitis was done by open repair [3]; however, reports from the Eurostar database [8] and a meta-analysis of EVAR of...

Ngày tải lên: 11/08/2014, 14:20

... integrity of the data and the accuracy of the data analysis. The authors disclose no conflict of interest for this study. Intramural funding through Emory University/Children's Healthcare of Atlanta ... significantly to the formulation of study design, collection of data, analysis, preparation and editing of this manuscript. Acknowledgements We thank our...

Ngày tải lên: 13/08/2014, 15:22

... normal lipase and esterase activities, and the structure of the K41 3A mutant is similar to that of wild-type LPL. The model of the R40 5A mutant, which has low lipase activity and a normal esterase ... monoclo- nal antibody against human LPL purified from postheparin plasma. One of the monoclonal antibodies, has an epitope similar to that of the 5D2 mon...

Ngày tải lên: 21/02/2014, 15:20

... secondary Ig [anti-(mouse IgG) Ig or anti-(sheep IgG) Ig; Sigma Chemical Co.] and the ECL system (Amersham-Pharmacia). Enzyme assays and trehalase activation Trehalase activity was assayed after ... dispensable for this activation of trehalase. The advantages of a complex bearing enzymes separately implicated in synthesis and breakdown of trehalose could provide improved con...

Ngày tải lên: 08/03/2014, 23:20

... plasmids and yeast strains. We are grateful to V.G. Daftari of Bharat Serums and Vaccine Ltd. Mumbai, for providing the facility to raise antibodies against Mrg19p. We thank K. Sastry and A. Atre ... T.S., Fukuma, M., Yano, K.I., Sakurai, H., Vonika, A. , Johnston, S .A. & Fukasawa, T. (1996) Analysis of the galactose signal transduction pathway in Saccharomyces cerevi...

Ngày tải lên: 31/03/2014, 08:20

... activity. CM-AAT1 is capable of transferring acyl residues into a variety of alcohols and CM-AAT2 is inactive towards the same substrates. CM-AAT1 has the same enzyme activity as a strawberry SAAT ... CM-AAT2 was amplified with RSB-5¢ and FSA-3¢:5¢-GATAATT CCACACCCTCCAATTA-3¢; the internal standard was amplified with act.5¢:5¢-gcactgaagagcatccggtacttc-3¢ and act3¢:5¢-TGGGCAC...

Ngày tải lên: 31/03/2014, 21:21

... Künzler and F Pataky for their technical assistance and G Pairo for the secretarial work. K Masuda is supported by the Japan Rheumatism Foundation, R Masuda by the Uehara Memorial Foundation and the ... factor-1 (Apaf-1) and could modulate a certain apoptotic pathway [28]. We can hypothesize, therefore, that these molecules are not only essential for cell survival and prol...

Ngày tải lên: 09/08/2014, 06:22

... difficult to invoke the spatial separation of populations as the only significant underlying cause of clear ly struc- tured sub-populations co-circulating in Africa (Af-Med and eAf-CA S) and Asia (S-AL, ... populations: Two factors driving the spread of a cassava mosaic disease pandemic. Plant Pathol 2004, 53:577-584. 55. Garcia-Arenal F, Fraile A, Malpica JM: Variation...

Ngày tải lên: 12/08/2014, 01:21

... ORF2, which encode a serine protease, an RNA-dependent RNA polymerase, and a structural protein, respectively [1,2]. AstVs are known to infect humans as well as a variety of mammalian and avian species ... however, that in the analysis of a phylogenetic tree based on the full ORF2 amino acid sequence, three clusters (HastV-1, 7, and 3; HAstV- 5and6 ;andHAstV- 4and8 )we...

Ngày tải lên: 12/08/2014, 01:21