Báo cáo y học: "A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose" pptx

... indicates that DNA repair pathways are a key determinant of cell survival after radiation, and that targeting the molecular components of these path- ways offers therapeutic potential [1-3]. When assessing ... modifiers on radiation sensitivity assume a constant effect independent of the radiation dose received. The aim of this study was to develop and evaluate...

Ngày tải lên: 13/08/2014, 16:21

... Circular binary segmentation for the analysis of array-based DNA copy number data. Biostatistics 2004, 5:557-572. 20. Venkatraman ES, Olshen AB: A faster circular binary segmenta- tion algorithm for ... assign a class value from C to each marker on a genome based on the R i val- ues such that the class assignment of consecutive markers and their raw copy number esti...

Ngày tải lên: 09/08/2014, 20:20

... or immunosuppressants can trigger these salutary effects. Lastly, the anti-inflammatory therapy is simulated as any drug/event leading to an increase of anti-inflammatory medi- ators, modeled here by the ... s i , for instance, may vary greatly during the flare cycle (changes in therapy, therapy failure or success), and can also vary greatly from patient to patient (stages of d...

Ngày tải lên: 13/08/2014, 16:20

... Tan A, Iasvovskaia S, et al. Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithe- lial ... these effects may not only contribute to the increased risk of infection 2 but may also be implicated in the increased rates of other forms of chronic inflammatory respiratory disease se...

Ngày tải lên: 08/08/2014, 21:20

... co-investigator of the repeated cross-sectional studies, performed the Geograph- ical Information System analysis, performed the statistical analysis and was responsible for the data management. UK was ... ratios (RR c ) demonstrate that cardio- vascular death was associated with impaired respiratory health and unfavourable lung function values. The associ- ation between cardi...

Ngày tải lên: 12/08/2014, 15:20

... Rauhut R, Meyer J, Borkhardt A, Tuschl T: New microRNAs from mouse and human. RNA 2003, 9:175-179. 52. Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tom- ida S, Yatabe Y, Kawahara ... conceived the study. AA collected the data and per- formed the data analyses. DACS and AA interpreted the results. DACS drafted the manuscript with assistance from AA. Both authors rea...

Ngày tải lên: 14/08/2014, 08:21

... Length of fol- low-up was at least 3 years with a maximum of 6 years. Location of facet pain was cervical in 45, tho- racic in 15, and lumbar in 114 patients. Surgical times varied based on the ... outcome measure was percent change in facet-related pain as measured by Visual Analog Scale (VAS) score at final follow-up visit. Secondary outcome was change in OSWESTRY disabil...

Ngày tải lên: 26/10/2012, 09:32

... data to warrant the use of these agents in a broad spectrum of psychiatric disorders, either as monotherapy, or as an augmentation strategy. Introduction Newer antipsychotic agents exhibit a ... sufficient hard data to warrant the use of these agents in a broad spectrum of psychiatric disorders, either as monotherapy, or as an augmentation strategy. Conflict of int...

Ngày tải lên: 08/08/2014, 20:23

... aspect of driving behavior was measured as a proxy of hyperactivity. Lane position was measured as the variabil- ity of the driver's position within lane. Reaction time was measured as the ... Biederman had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Refe...

Ngày tải lên: 08/08/2014, 21:20

... included in the meta-analysis of light therapy for depression, eight for light therapy for SAD, and five for dawn simulation for SAD. The meta-analyses revealed a large effect of light therapy (d = ... looked exclusively at light therapy for non-seasonal depression and applied broader inclusion criteria for trials [163]. A total of 18 RCTs were analysed, however on...

Ngày tải lên: 08/08/2014, 23:21