Báo cáo y học: "Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models" pot

... 2002 A single charged surface residue modifies the activity of ikitoxin, a beta-type Na + channel toxin from Parabuthus transvaalicus A. Bora Inceoglu 1, *, Yuki Hayashida 2 , Jozsef Lango 3 , Andrew ... Laboratory, University of California, Davis, CA, USA We previously purified and characterized a peptide toxin, birtoxin, from the South African sco...

Ngày tải lên: 31/03/2014, 08:20

... coronary angiography in the study by Weiss et al. showed a higher sensitivity and specificity for the detection of coronary stenosis by 3DMP than by 12-lead ECG [18]. One lim itation of the ... systems. In the case of the heart, analysis is performed on the signals emitted by the heart, such as the surface resting electrical signal recorded by an ECG....

Ngày tải lên: 08/08/2014, 16:23

... nonobstructive coronary artery disease. Heart Dis. 2002; 4: 2-12. 22. Grube E, Bootsveld A, Yuecel S, et al. Computerized two-lead resting ECG analysis for the detection of coronary artery stenosis. ... Computerized two-lead resting ECG analysis for the detection of coronary artery stenosis after coronary revascularization Eberhard Gru...

Ngày tải lên: 08/08/2014, 17:20

... Monoclonal Antibodies against Nucleophosmin Mutants: Potentials for the Detection of Acute Myeloid Leukemia Shi Tan 1 , Ling Zhang 1  , Xiao-Ming Zhong 1 , Zai-Lin Yang 2 , Liu-Yang Zhao 1 , Yu-Jie ... value of their detection by immunocytochemistry. Blood. 2002; 99: 409-26. 17. Falini B, Mecucci C, Tiacci E, et al. Cytoplasmic nucleophosmin in acute myelo...

Ngày tải lên: 08/08/2014, 18:21

... for analysis was the higher of the two knees. We define generalized OA (GOA) by the hypothesis that OA found in the hand is an indicator of disease in other large joints, including the spine. An individual ... CRP, pyridinoline, YKL-40, MMP-3 and TIMP-1 levels each related to at least one of the radiographic gradings. Furthermore, pyridinoline related to every type...

Ngày tải lên: 09/08/2014, 01:23

... article Hypothalamic-pituitary-adrenal stress axis function and the relationship with chronic widespread pain and its antecedents John McBeth 1 , Yee H Chiu 2 , Alan J Silman 1 , David Ray 3 , ... pain. These results may be explained by the associated high rates of psychological distress and somatisation. We address the hypothesis that the latter, rather than...

Ngày tải lên: 09/08/2014, 06:23

... sIL-1R, increasing the binding affinity of IL-1α and IL-1β to type II sIL-1R by approximately 100-fold, while leaving unaltered the low binding affinity of IL-1Ra to type II sIL-1R, thus enhancing inhibition ... are broader and include activating or increasing the level of factors able to inhibit proinflammatory cytokines or other catabolic factors. Interleukin-1 β For s...

Ngày tải lên: 09/08/2014, 07:20

... transfer of anti-lysozyme antibodies to mice that are locally injected in one knee joint with poly-L-lysine-coupled lysozyme. Poly-L- lysine-coupled lysozyme is highly cationic and sufficiently large ... in every experimental arthritis model. Although IL-1 is not a dominant early inflam- matory cytokine in all models, it is the pivotal cytokine in inhibition of chondrocyte proteoglyc...

Ngày tải lên: 09/08/2014, 14:22

... problem among women of reproductive age. The behavior and other characteristics of the male partners in this study were important predictors for HIV in women. Therefore, involvement of men in HIV prevention ... regarding the male partner& apos;s behavior characteristics was reported by the women. The accuracy may be low due to lack of openness regardin...

Ngày tải lên: 10/08/2014, 05:20

... participated in the design of the study and the analytical plan. DEF participated in the design of the study, the analytical plan, the interpretation of the results, and assisted in drafting the manuscript. ... manuscript. DS and ES participated in the design of the study, the analytical plan, the interpretation of the results, and assiste...

Ngày tải lên: 11/08/2014, 17:20

... medium, provided the original work is properly cited. Research Factors associated with mosquito pool positivity and the characterization of the West Nile viruses found within Louisiana during 2007 Rebecca ... article as: Christofferson et al., Factors associated with mosquito pool positivity and the characterization of the West Nile...

Ngày tải lên: 12/08/2014, 04:20

... design of the study and helped to draft the manuscript. EL participated in the design of the study and helped to analyse the data. RH helped to analyse the data. CSU participated in the design of the ... 2-year mortality of 36 [6] to 49% [5]. Several studies have been conducted in order to identify the risk factors of mortality in COPD and there is...

Ngày tải lên: 12/08/2014, 16:20

... quantities of Vpr. 2). Vpr promotes the binding of the PIC (including MA, integrase (IN) and proviral DNA) to importins and nucleoporins, thereby facilitating nuclear entry of HIV- 1 provirus into the ... pre- viously, Vpr plays a significant role in the permissive infection of HIV- 1 into macrophages and may increase the survival of infected myeloid cells; t...

Ngày tải lên: 13/08/2014, 01:20

... Biology and Medical Modelling Open Access Research Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based ... to predict the effect of the CYP3A4 inhibitors, itraconazole (ITZ) and its primary metabolite, hydroxyitraconazole (OH-ITZ) on the pharmacokineti...

Ngày tải lên: 13/08/2014, 16:21

... RESEARCH Open Access Endogenous plasma activated protein C levels and the effect of enoxaparin and drotrecogin alfa (activated) on markers of coagulation activation and fibrinolysis in pulmonary ... and VIIIa [1]. Inactivation of factor VIIIa reduces the acti vity of the tenase complex and the production of factor Xa. Inactivation o...

Ngày tải lên: 14/08/2014, 07:21