Báo cáo y học: "Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability" ppt

... Corresponding author Abstract Background: The body's primary stress management system is the hypothalamic pituitary adrenal (HPA) axis. The HPA axis responds to physical and mental challenge ... purposes) Theoretical Biology and Medical Modelling Open Access Research Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis mo...

Ngày tải lên: 13/08/2014, 16:21

... These data suggest that BiP has a negative effect on the folding of TSHR. The interaction of this receptor with BiP leads to an increase in the degradation of TSHR and also to a decrease in the amount ... previously demonstrated that the inhibition of N-glycosylation by tunicamycine leads to a decrease in the amount of TSHR present at the cell surface [26...

Ngày tải lên: 31/03/2014, 08:20

... SJR, Winyard LA, Medhurst SJ, Clayton NM, Wilson AW, Kendall DA, Chapman V: Activation of CB 1 and CB 2 receptors attenuates the induction and maintenance of inflammatory pain in the rat. Pain ... therapeutic target for the treatment of pain and inflammation associated with OA and RA. 2-AG = 2-arachidonyl glycerol; AEA = anandamide; CB 1 = cannabinoid receptor 1; CB 2 = ca...

Ngày tải lên: 09/08/2014, 10:23

... history of gradually worsening numbness and paresthesia on the palmar aspect of the left thumb and thenar eminence. Clinical examination reveals a hypoaesthesia in the median nerve area of the ... and a few cases of ulnar nerve compression in the forearm [11] and the Guyon's canal [20-22]. The involvement of the median nerve was also reported in the...

Ngày tải lên: 10/08/2014, 10:20

... midshaft fracture of the clavicle makes the case even more interesting and remarkable. Case presentation In the las t two kilometres of the cycling split in an Iron- mantriathlonahighlytrainedathletehitaduckinthe street ... a family physician and thus knows the available options, he asked for an intramedullary nail and the surgeon agreed. Post-surgi- cally, the pain di...

Ngày tải lên: 10/08/2014, 10:20

... pheochromocy- tomas. The remaining ten percent are extra adrenal and are termed paragangliomas. Paragangliomas appear in the abdomen, pelvis, neck and mediastimun. Mediastinal paraganglioma originate from para-aortic ... in majority of cases they are non- functional. Up to 50% of patients are asymptomatic and the diagnosis is incidental [1]. Clinical symptoms may be related to...

Ngày tải lên: 10/08/2014, 10:20

... Hepatology 2007, 46:122-129. 18. Sugamura K, Sugiyama S, Nozaki T, Matsuzawa Y, Izumiya Y, Miyata K, Nakayama M, Kaikita K, Obata T, Takeya M, Ogawa H: Activated endocannabinoid system in coronary ... Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA: Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hype...

Ngày tải lên: 11/08/2014, 03:20

... this article as: Ypsilantis and Tisi: Involvement of the genicular branches in cystic adventitial disease of the popliteal artery as a possible marker of unfavourable early clinical outcome: a case ... unfavourable early clinical outcome: a case report Efthymios A Ypsilantis 1* , Paul V Tisi 2 Abstract Introduction: Cystic adventitial disease of the popliteal artery is...

Ngày tải lên: 11/08/2014, 12:20

... associated loss of function and the feeling of pain. On mammography, the typical appearance was of a sin- gle or multiple skin lesions proj ecting over the mam- mary parenchyma. Portions of the ... were rich in mucopolysaccharide and variably collagenous (Figures 4a and 4b). The collagen fibres were typically delicate and lay within a matrix that was variable, abun- d...

Ngày tải lên: 11/08/2014, 14:21

... football, ballet dancing, equestrian jumping, parachuting and snowboarding. Case presentation: A 20-year-old man was injured whilst playing football. He felt a pop in the right knee and was subsequently ... fibular head. Photograph of the knee showing anterolateral dislocation of the proximal tibiofibular jointFigure 1 Photograph of the knee showing anterolateral dislo- ca...

Ngày tải lên: 11/08/2014, 23:21