Báo cáo y học: "Relating a calcium indicator signal to the unperturbed calcium concentration time-course" potx

... indicator at a rate kf and isproportional to the concentration of free calcium, x(t), aswell as to the concentration of the free indicator, y max - y( t). Calcium disassociates from the indicator ... free indicator concentration becomes y max -y( t). The concentration y max is the initiallevel of the free indicator dye immediately after injectionin the case of synthetic dyes, or the total amount ... and by average mutual information. For every U(t)there is an associated indicator signal V(t), and since wehave already totally characterized the state of the neuronby U(t) there must be a...

Báo cáo Y học: Barley a-amylase Met53 situated at the high-afﬁnity subsite )2 belongs to a substrate binding motif in the bﬁa loop 2 of the catalytic (b/a)8-barrel and is critical for activity and substrate speciﬁcity pot

... TAA (in black). The superimpositioning was guided by the catalytic acids (D179AMY2, E204AMY2, and D289AMY2andD206TAA, E230TAA, and D297TAA). The invariant Y5 1AMY2and Y8 2TAAare ... arrow). Y5 1AMY2and Y8 2TAAare in orange. Otherbinding residues (W9AMY2, H92AMY2, T94AMY2, A9 5AMY2, Y1 30AMY2, A1 45AMY2, F180AMY2, K182AMY2, W206AMY2,S208AMY2, Y2 11AMY2, ... stackedat subsite )1 onto the valienamine ring in AMY2/acarbose(Fig. 1A) . Superpositioning of AMY2 and TAA guided by the catalytic acids was excellent for Tyr51AMY2andTyr82TAA(Fig. 1A) and...

Báo cáo y học: " NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitid" pot

... chromosomal inversions (Additional data file 1). To achieve an annotation as accurate as possible, we anno-tated 8013's genome manually by taking advantage of all the functionalities of the ... CDSs have thus been manually curated,bringing the grand total to approximately 6,400 (Table 4). Asabove, all these datasets are stored in NeisseriaScope and arereadily accessible online. During ... (MaGe) for data visualization and exploration; and the large Prokaryotic Genome DataBase (PkDGB) for datastorage, which contains more than 400 microbial genomes.We devoted particular care to...

Báo cáo y học: "Wheelbarrow tire explosion causing trauma to the forearm and hand: a case report" ppt

... forearm and left hand were fractured.In particular, a second degree open complete diaphysealforearm fracture AO type A3 [1], a distal radius fractureAO type B1, a fracture of the fourth metacarpal ... Kirschner wires. The postoperative X-ray (Figure 1)showed a stable osteosynthesis of the forearm and distalradius allowing immediate mobilisation. The metacarpaland the middle phalanx fracture were ... Preoperative image of the fracture of the forearm shaft and distal radiusFigure 1 (A) Preoperative image of the fracture of the forearm shaft and distal radius. (B) Image of the fracture of the...

Báo cáo y học: " Pruritus: a useful sign for predicting the haemodynamic changes that occur following administration of vancomycin" ppsx

... the coronary patients were adequately monitored and the anaes-thetist was therefore in the optimal conditions to detect andtreat any change in cardiorespiratory function at an early stage.Our analysis ... ST-segment analysis; radial arterycannula and pulmonary artery catheter [Arrow AH 050050-H,7.5 F; Arrow International, Inc., Reading, PA, USA] transcuta-neous oxygen saturation probe), vancomycin ... 4). Apartfrom collection of haemodynamic data, at each time point twoblood samples were drawn (one from the radial artery cannulaand another from the distal port of the pulmonary arterycatheter)...

Báo cáo y học: "Correction: A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes" pdf

... Gornik I, Vujaklija-Brajković A, Renar IP, Gašparović V: A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent ... medical ICU patients and subsequent development of type 2 diabetesIvan Gornik*1, Ana Vujaklija-Brajković1, Ivana Pavlić Renar2 and Vladimir Gašparović1See related research by Gornik et al., ... of type 2 diabetes. Critical Care 2010, 14:R130.© 2010 BioMed Central LtdCorrection: A prospective observational study of the relationship of critical illness associated hyperglycaemia in...

Báo cáo y học: " Does a new polyomavirus contribute to Merkel cell carcinoma" pot

... with a circular double-stranded DNA genome of approximately 5 kb.It has been well established that many polyomaviruses areable to transform mammalian cells [14]. The best-characterized polyomavirus, ... that the discovery of MCPyV by Chang and Mooreand their team [11] has opened up important new avenuesthat should illuminate MCC biology and also that the DTStechnique may be applicable to the ... animal cancers.Polyomavirus family members are known to have two otherT antigen proteins with transforming ability. MCPyV ispredicted to express a small T antigen that is able to bind to and...

... generates easy -to- navigate, annotated HTML pages as output. (a) The L2L web interface. (b) The Results summary page displays each list from the database that significantly matched the data, along ... expression changes caused by a well-definedperturbation may lead immediately to a hypothesis regarding the underlying mechanism in the system under study.L2L is a database and associated software tool ... genes one-by-one, there is no simpleway to compare our data en masse with any other data in the repository, much less against all the data in the repository.Furthermore, repositories can make it...

Báo cáo y học: "ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data" docx

... detected by comparative hybridization to a DNA microarray. Standard technical recommendationscommon to all microarray experiments (for example, the need for dye swaps) apply equally to ChIP-chip ... density'of the peak, and the P value for that peak. The array densityvalue is defined as the average number of arrayed elementsused to calculate the window values for all windows that com-prise the ... the peak. Therefore, the array density value provides anestimate of the number of actual raw data measurements thatunderlie each peak. The last sheet, Description, contains a summary of the ChIPOTle...

Báo cáo y học: "BoCaTFBS: a boosted cascade learner to refine the binding sites suggested by ChIP-chip experiments" pot

... relevant to the rules here. The overall sum of all the nodes is +0.803, a confident score indicating that this is predicted to be a binding site.AACAGGAATAATCAAGACATTTCACGAATG…… ……ACGTCGATACBinding ... sensitivity level. The consensus approach has the worstperformance, as anticipated; the other three traditionalmethods had comparable performance. Additionally, for ourBoCaTFBS method, a P value was ... because of the compu-tational inefficiency for training over massive datasets [41].Efficiency and scalability are key challenges for handlingmassive datasets in a boosting paradigm [42]. The...

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