Báo cáo y học: " A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms" pps

... fre- quencies of alleles A and a are q and 1 - q, respectively. For a particular genotype j of this QTL (j = 0 for aa, 1 for Aa and 2 for AA), the parameters describing circadian rhythms are denoted by Θ uj ... the model. Model Mathematical Modeling of Circadian Rhythms In all organisms studied so far, circadian rhythms that allow adaptation to a periodically...

Ngày tải lên: 13/08/2014, 16:21

... 8 1 2 3 4 5 6 7 8 Time Number of clones AA actual AA fitted Aa actual Aa fitted aa actual aa fitted 1 2 3 4 5 6 7 8 1 2 3 4 5 6 7 8 Time Number of clones AA actual AA fitted Aa actual Aa fitted aa actual aa fitted CD 1 ... 8 0 2 4 6 8 10 12 Time Number of clones AA actual AA fitted Aa actual Aa fitted aa actual aa fitted 1 2 3 4 5 6 7 8 0 2 4 6 8 10 12 Time Number of clones AA actual...

Ngày tải lên: 13/08/2014, 16:21

... not financially viable. However, based on risk profile and a higher rate of RSV-related hospitalisation, a certain proportion of these infants may be legitimate candidates for prophylaxis. A comprehensive ... presented a challenge as there were no suitable databases in Europe that were avail- able for such a purpose. As a surrogate, the model was tested against data fr...

Ngày tải lên: 12/08/2014, 14:20

... shape analysis and biological princ iples behind shape formation and variation. Shape Analysis According to the definition of Kendall [31], “shape is all the geometrical information that remains ... RL, Ma C-X, Casella G: Statistical Genetics of Quantitative Traits: Linkage, Maps, and QTL Springer-Verlag, New York 2007. 31. Dryden IL, Mardia KV: Statistical Shape Analysis John Wiley &am...

Ngày tải lên: 13/08/2014, 16:20

... these are congregated in fundamental clusters. Finally, we modeled the case when, in a community of cells that have already formed a biofilm, a si gnal that activates the OmpR regulator and then ... be modeled and analyzed efficiently, making strong simplifying assumptions about the structure and dynamics of a genetic regulato ry system [17]. In this model each cluster (a g...

Ngày tải lên: 13/08/2014, 16:20

... produce circadian rhythms out of different components in different organisms, as is actually observed [4]. This mechanism has the added advantages of robustness and easy adaptability (the period of ... genetic oscillators. Proc Natl Acad Sci USA 2002, 99:5988-5992. 7. Leloup JC, Goldbeter A: Toward a detailed computational model for the mammalian circadian clock. Proc Natl...

Ngày tải lên: 13/08/2014, 16:21

... concentration of Mg 2+ as a mul- tiplier raised to the first power; however, they additionally assumed that Mg 2+ and ASP may act cooperatively. Our calculations demonstrate that an even simpler model, which ... procedure was under way. The values obtained for the parameters are shown in Table 1. Methods The model to describe the reaction catalyzed by adenylo- succinate synthe...

Ngày tải lên: 13/08/2014, 16:21

... and absence of exter- nal calcium. We note that Heinze et al, [2], created a math- ematical model for LH release that reproduces some data for pulsatile administration of GnRH. Their model, how- ever, ... most of the important intracellular mechanisms known to play important roles; thus, they match data but do not study mechanisms. We also note that mathematical models f...

Ngày tải lên: 13/08/2014, 22:22

... non-linear PCA software package for MATLAB ® available at [28]. Data acquisition and preprocessing This analysis is based on microarray data of the P. falciparum HB3 strain from the experimental ... data [25,26] or to use the reduced data of PCA for further analysis. While standard PCA is a linear technique that reduces the dataset by identifying a linear subspace that descri...

Ngày tải lên: 14/08/2014, 08:21

... records was made. The package in EXCEL format was exported to SPSS format for its later sta- tistical analysis, and the quality controls were also made at this stage. Statistical analysis An initial ... Dukes’ stages I and IIA by means of validation of a previous original model [18]. The model, validated by means of logistic regression and “bootstrap” analysis, contains t...

Ngày tải lên: 03/11/2012, 11:34