Báo cáo y học: "Cancer initiation and progression: an unsimplifiable complexity" pot

... new ways of understanding the complex processes underlying cancer initiation, progression and metastasis [19- 23]. Initiation and progression of cancers Cancer is today recognized as a highly heterogeneous ... between natural and cancer cells may involve both qualitative and quantitative aspects. Recently, the development of recurrent cancers and sec- ond primary tumours (SPTs) h...

Ngày tải lên: 13/08/2014, 16:21

... the discovery of protein kinases by Burnett and Kennedy (J Biol Chem 1954, 211:969-980) and 25 years since the discovery of tyrosine phosphorylation by Hunter and colleagues (Eckhart et al., Cell ... together many of the specialists, mainly from Europe and the USA, working on cancer and signal transduction. It was the 20th meeting in this series, and celebrated 50 years since the...

Ngày tải lên: 09/08/2014, 20:20

... Haznedaroglu IC, Erman M, Tekuzman G: Old antihypertensives as novel antineoplastics: angiotensin- I-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists. Medical Hypotheses 2002, ... plasticity and angiogenesis via the vascular endothelial growth factor (VEGF) [56]. It has been postulated that losartan and other AT1 blockers can act as novel anti-angiogenic, anti...

Ngày tải lên: 11/08/2014, 08:21

... its steady state condition after a random perturbation in the individual birth and death rates. This property can be analytically described in terms of the quantity evolutionary entropy, an information ... BAD, and cell death. Importantly, inhibition of glycolysis effectively kills colon cancer cells and l ymphoma cells in a hypoxic environment in which the cancer cells exhibit high g...

Ngày tải lên: 13/08/2014, 16:20

... at http://arthritis-research.com/viewpoints/reflinks6_01.asp Correspondence Ranjeny Thomas, Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Brisbane, 4102, Australia. Tel: +61 7 32405365; ... tolerance, and in counterbalancing the proinflammatory effects of IL-1 and IL-17. Conclusions Although apparently simple, the concept of a third (c...

Ngày tải lên: 09/08/2014, 01:23

... Y, Tian G, Goodman L, Fan W, Zhang J, Li J, Zhang J, Guo Y, Feng B, Li H, Lu Y, Fang X, Liang H, Du Z, Li D, Zhao Y, Hu Y, Yang Z, Zheng H, Hellmann I, Inouye M, Pool J, Yi X, Zhao J, Duan J, ... strongly evolutionarily conserved or in genes associated with severe disease. This analysis identified 773 potentially medically relevant variants. As in the ancestry analysis, the common...

Ngày tải lên: 09/08/2014, 20:20

... contributions GC and JD drafted the manuscript. FH, LH, SM, CH, FC, JD and NL participated in the design of the study. GC and JD conceived of the study, and participated in its design and coordination. ... purposes before surgery. Both girls and boys were prepubescent (between 5 and 96 months). Patients with Turner Syndrome were older (between 72 and 186 months). The study was...

Ngày tải lên: 11/08/2014, 03:20

... contributions GC and JD drafted the manuscript. FH, LH, SM, CH, FC, JD and NL participated in the design of the study. GC and JD conceived of the study, and participated in its design and coordination. ... gender differences can depend on the type and intensity of the stimulus, and vary according to the considered cytokine. LPS induced similar levels of IL1 production in males...

Ngày tải lên: 11/08/2014, 06:22

... statistical analysis, and drafted the manuscript. MI, AI, YO, KU, YI, TT and KI conceptualized and designed the study, collected the data. HH, YT, NK, MN and YO conceptualized and designed the study. ... details 1 Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan. 2 Schizophrenia Research Team, Tokyo Institute of Psychiatry, Tokyo, Japan. 3 Faculty of Med...

Ngày tải lên: 11/08/2014, 16:22

... for lean mass (lean mass- resid ) represents the part of lean mass not accounted for by height and fat mass (i.e., the correlations between lean mass resid and height, and lean mass resid and ... assisted with study design and writing; SS assisted with study design and implementation; EY assisted with writing and reviewing of the final manu- script;PL managed study recruitment...

Ngày tải lên: 12/08/2014, 15:20