Báo cáo y học: "Macrophage migration inhibitory factor in cerebrospinal fluid from patients with central nervous system infection" potx

... 3 Research Macrophage migration inhibitory factor in cerebrospinal fluid from patients with central nervous system infection Christian Østergaard 1 and Thomas Benfield 2,3 1 Department of Clinical Microbiology, ... significantly with meningeal inflammation (P < 0.05) but not with systemic inflammatory response (P > 0.05) in patients with purulent menin...

Ngày tải lên: 13/08/2014, 16:21

... [21,22]. Macrophage migration inhibitory factor (MIF) was originally identified as a protein derived from T lymphocytes [23,24]. MIF is a proinflammatory cytokine produced by macrophages in response to inflammatory ... expression by synovial lining cells in zymosan-induced arthritis (ZIA) joints of MIF -/- miceDecreased MMP-2 expression by synovial lining cells in zymosan-induce...

Ngày tải lên: 09/08/2014, 08:22

... immunohis- tochemical staining to compare the expression of MIF and RANKL in synovial tissues. More intense staining of MIF and RANKL was observed in synovium from patients with RA compared with synovium from patie ... N-terminal kinase; MAPK: mitogen-activated protein kinase; M-CSF: monocyte-colony stimulating factor; MEM: minimal essential medium; MEK1: MAP kinase kinase-1; M...

Ngày tải lên: 12/08/2014, 15:22

... Within the context of inflammatory responses, the Th1 pathway controls macro- phage activity, which is the main source of proinflammatory cytokines. These proinflammatory cytokines are highly ... shown to increase during cardiopulmonary bypass, which may directly induce MIF secretion by immune cells [6]. MIF thereby stimulates Th1 immune activity and induces proinflammatory cytokines and ampl...

Ngày tải lên: 12/08/2014, 23:23

... and, in part, by the host’s own inflammatory response. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and a neuro-endocrine mediator that might play a role in pneumococcal ... therapy in pneumococcal meningitis. In the previous issue of Critical Care, Ostergaard and Benfield [1] described cerebrospinal fluid macrophage migration inhibitory f...

Ngày tải lên: 13/08/2014, 18:22

... primary antibody. Represen- tative pictures were recorded prior to destaining the slides of hematoxylin with 1% HCl in 70% ethanol. The hematoxylin destained samples were assessed in a blinded ... inflammatory process in allergic rhinitis (AR) involves many different inflammatory cells, cytokines, chemokines and other regulatory molecules [1]. It is well known that exposure to allerge...

Ngày tải lên: 08/08/2014, 21:20

... Trial Evaluating Long-Term Efficacy and Safety for Ankylosing Spondylitis; BASDAI: Bath Ankylosing Spondylitis Disease Activity Index; BASFI: Bath Ankylosing Spondylitis Functional Index; BASMI: ... modified Stoke Ankylosing Spondylitis Spine Score; NSAID: nonsteroidal anti-inflammatory drug; OASIS: Outcome in Ankylosing Spond- ylitis International Study; PCS: physical component summary; P...

Ngày tải lên: 09/08/2014, 14:22

... approach with the physicochemical approach in quantifying complicated metabolic acidosis in patients in the intensive care unit Patients and methods We included 50 consecutive patients with a metabolic ... study was to compare two differ- ent methods of quantifying metabolic acidosis in patients admitted to an ICU. We were especially interested in whether acid–base analy...

Ngày tải lên: 12/08/2014, 19:22

... on central nervous system (CNS) cytokines (Interleukin 6 and tumor necrosis factor) , lactate and perfusion pressures, testing the hypothesis that intra-abdominal hypertension (IAH) may possibly lead to ... Changes in cerebrospinal fluid pressure and lactate concentrations during thoracoabdominal aortic aneurysm surgery. Anesthesiology 1997, 86:41-47. 50. Khan SN, Stansby G: Cer...

Ngày tải lên: 13/08/2014, 20:21

... be secreted by macrophages, but not pl atelets, and they play important roles in mediating pro-inflammatory responses. Interestingly, the pro-inflammatory cytokine secretion was also enhanced by platelets ... expressing surface phosphatidylserine is usually immunosuppressive [2,26,27,53,54]. In the present study, co-culture with apoptotic cells inhibited production of pro-inflammatory c...

Ngày tải lên: 11/08/2014, 03:20