... coagulopathy, suffi cient activators seem to be present. Because of the question of activators, the authors see fi brinogen administration as adjunctive therapy to be used concomitantly with replacement ... KM, Tonnesen E, Ingerslev J, Sorensen B: Fibrinogen substitution improves whole blood clot rmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy: ... Flinck A, Skrtic S, Jeppsson A: Prophylactic brinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study. Thromb Haemost 2009, 102:137-144.10....