... specificity of thisdomain, with residues Tyr91 and Tyr137 forminginteraction pocket 1; Tyr93, Tyr137 and Trp119 form-ing pocket 2, and the valley between n-Src and RTloops included by Trp119 and Tyr132 ... grooves 1 and 2 created by the n-Srcloop and the 310helix, stabilized by stacking interac-tions of the pyrrolidine ring of Pro7 with the aromaticside chain of Tyr137. Modelling of the PRD1-superpeptide, ... highlighted the importance of the Fyn SH3-domain interaction in initi-ating the association with PAG, and how this affectstyrosine phosphorylation and thereby the functionality of PAG as a...