Báo cáo y học: "Inhaled activated protein C: a novel therapy for acute lung injury" pot

... Waerhaug and colleagues [1] test the hypothesis that inhaled activated protein C (APC), a novel therapy approved for the treatment of severe sepsis [2], may be an effective treatment for acute lung ... demonstrate for the first time that APC administered by the inhaled route may have benefit in ALI by improving gas exchange. Given the increase Commentary Inhaled activated...

Ngày tải lên: 13/08/2014, 16:20

... 1667. doi:10.1186/cc8977 Cite this article as: Abraham E: Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury? Critical Care 2010, 14:144. Abraham Critical Care 2010, 14:144 ... 204:2439-2448. 6. Bae JS, Yang L, Rezaie AR: Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid r...

Ngày tải lên: 13/08/2014, 20:21

... 9:321-322. 17. Bradley EL: A clinically based classification system for acute pancreatitis. Summary of the international symposium on acute pancreatitis, Atlanta, Ga, September 11 through 13, 1992. Arch ... ther- apy-free days, va sopressor-free days), days alive outside hospital in 60 days, and changes in other laboratory values during the first five days. Radiologic assessment An ab...

Ngày tải lên: 13/08/2014, 21:21

... BT, Schoenfeld D, Anzueto A, Matthay MA: Airway pressures and early barotrauma in patients with acute lung injury and acute respiratory distress syndrome. Am J Respir Crit Care Med 2002, 165:978-982. 29. ... Industrial Mathematical Sciences, University of Manitoba, Winnipeg, Manitoba, Canada and 3 Department of Pathology and Laboratory Medicine, James Hogg iCAPTURE Centre for Cardi...

Ngày tải lên: 12/08/2014, 18:21

... drug concentration is necessary, particularly with changes in drug dose and clinical status. Second, metabolites may accumulate with AKI. Be aware of potential pharmacologically active metabolite accumulation with ... even hepatically eliminated drugs and formed drug metabolites may accumulate during AKI, and renal replacement therapy may affect nonrenal clearance as well as drug metabolite...

Ngày tải lên: 13/08/2014, 11:23

... luminometer (EG & G Berthold, Bad Wildbad, Germany), and expressed in arbitrary units. Statistical analysis One- or two-way analysis of variance, as appropriate, and Tukey's test were performed ... acetylcholine (ACh) from choline and acetyl coenzyme A is catalyzed by the enzyme choline acetyltransferase (ChAT, acetyl-CoA:cho- line O-acetylotransfe rase, EC 2.3.1.6) [1]. Following...

Ngày tải lên: 31/03/2014, 21:21

... 4°C for immedi- ate use or -20°C for long-term storage. The SP -A was ana- lyzed for purity by SDS-PAGE and for endotoxin contamination using the Limulus amebocyte lysate assay (Associates of Cape ... intracellular kinases. Studies with Leishmania have shown that entry of organisms into non -activated macrophages is accompanied by activation of protein tyrosine phosphatases that i...

Ngày tải lên: 12/08/2014, 14:20

... as an APACHE [Acute Physiology and Chronic Health Evaluation] II of ≥ 25’. APACHE II ≥ 25 was used as one marker of high risk of death because a subset data analysis demonstrated that the treatment ... Page 1 of 2 (page number not for citation purposes) ADDRESS = Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis; APACHE = Acute Physiology and Chronic Health Ev...

Ngày tải lên: 12/08/2014, 23:21

... been identified as participating in the anticoagulant activity but not in cellular effects. Hence, variants have been designed with greater anti-apoptotic activity and reduced anticoagulant activity relative ... endothelium therapy Clearly, in cellular and animal models, rAPC has been given either as a pre-treatment or concurrent with septic challenge. This mode of administration favours...

Ngày tải lên: 13/08/2014, 03:20

... permanent radioactive implants (brachytherapy) [7]. iv) The standard initial systemic therapy for locally advanced or metastatic disease is hormonal or androgen depri- vation therapy (ADT) that ... Nagahara S, Makita N, Tarumi Y, Kadomatsu K, and Takei Y. Systemic delivery of siRNA specific to tumor mediated by atelocollagen: Combined therapy using siRNA targeting Bcl-xL and c...

Ngày tải lên: 26/10/2012, 09:48