Báo cáo y học: " Mathematical model insights into arsenic detoxification" pptx

... article as: Lawley et al.: Mathematical model insights into arsenic detoxification. Theoretical Biology and Medical Modelling 2011 8:31. Lawley et al. Theoretical Biology and Medical Modelling 2011, ... inorganic arsenic LiAs-stor liver storage of inorganic arsenic LMMAs liver monomethyl arsenic LDMAs liver dimethyl arsenic LDMAs-stor liver storage of dimethyl arsenic UiAs...

Ngày tải lên: 13/08/2014, 16:20

... The availabil- ity of genome databases and advancements in analytical technology, especially mass spectrometry, has made it possible to study many phosphoproteins and phosphorylation sites at ... and the discovery of new phos- phorylation sites in known signaling proteins. As enzymatic catalysis by protein kinases is the only known physiological mechanism for phosphorylation of serine, ... ph...

Ngày tải lên: 14/08/2014, 14:22

... complete redundancy, quantitative redun- dancy, and incongruent redundancy. e latter category was unexpected yet is relatively common and can arise from partial redundancy between two factors ... treatment. e sensi- tivity of this approach meant that they could identify about tenfold more protein-coding genes rapidly regu lated by estrogen than did microarrays. Moreover, the data revea...

Ngày tải lên: 09/08/2014, 20:22

... mainly due to the fact that the brain is uniquely dependent on the availability of glucose and that dysglyc- emia, either hypoglycemia or hyperglycemia, would induce brain dysfunction. Not only ... glucose utilization by erythrocytes, which is assumed to occur only in the arterial compartment for simplification, although the glucose is physiologically uti- lized by erythrocytes in all blood ....

Ngày tải lên: 13/08/2014, 16:20

... rouleaux, assuming that viscosity is determined by the numbers of erythrocytes only at a high yield velocity (since high yield velocities destroy rouleaux). Granted this assumption, the viscosity is determined ... resemble those of a solid body. When the yield velocity increases, the length of the rouleaux gradually decreases and ulti- mately only stand-alone erythrocytes are left. To test th...

Ngày tải lên: 13/08/2014, 22:22

... transferred N-acetylgalactosamine into the second Thr residue only when N-acetylgalactosamine was attached to the third one. Keywords: O-glycosylation; mucin; polypeptide N-acetylga- lactosaminyltransferase; ... UDP-GalNAc. Biosynthesis of O-glycans is mediated by the step-wise addition of monosaccharides by a variety of glycosyl- transferases, where topology and kinetic properties of Golgi...

Ngày tải lên: 17/03/2014, 10:20

... a three-dimensional model of the ligand binding domain (LBD) of the mouse aryl hydrocarbon receptor (mAhR). The model allowed us to putatively i dentify the residues responsible for the recognition of polychlorinated ... by AhR receptors and to formulate an hypothesis on the signal transduction mechanism. Keywords: aryl h ydrocarbon receptor; polychlorinated dibenzo-p-dioxins; structure p...

Ngày tải lên: 24/03/2014, 00:21

... 3-hydroxy-3-methylglutaryl-coenzyme A; IFN = interferon; i.p. = intraperitoneally; LPS = lipopolysaccharide; Th = T helper cell; TNF = tumour necrosis factor. Arthritis Research & Therapy ... both capacities. Statins are particularly topical in this regard. Statins (3-hydroxy-3-methylglutaryl-coenzyme A [HMG- CoA] reductase inhibitors) are widely prescribed for indi- viduals at increased...

Ngày tải lên: 09/08/2014, 01:23

... part, mediated by IL-1 and/or TNF-α. Oncostatin M (OSM), a cytokine produced by activated T cells and macrophages, is structurally and functionally related to the IL-6 cytokine family. Raised levels ... Shaughnessy SG: Stimulation of osteoclast differentiation in vitro by mouse oncostatin M, leukaemia inhibitory factor, cardiotrophin-1 and interleukin 6: synergy with dexamethasone. Cytokine 2...

Ngày tải lên: 09/08/2014, 06:22

... pool with NHS-cyanine dyes (Cy3 and Cy5; Amersham Biosciences, Amersham Place, England). The two labeled probes were hybridized with the array for 16 h at 65°C. Arrays were scanned by using a 4000B ... 2:737-744. 7. Whitfield ML, Finlay DR, Murray JI, Troyanskaya OG, Chi JT, Per- gamenschikov A, McCalmont TH, Brown PO, Botstein D, Connolly MK: Systemic and cell type-specific gene expression p...

Ngày tải lên: 09/08/2014, 08:22