... a limiting factor in avascular islets, hypoxia can limit insu-lin secretion. The oxygen dependence of local insulin release has be en parameterizedso as to fit the only detailed data available, ... the local availability of oxygen. A total offour concentrations are modeled for local and released insulin (cinsL, cins), glucose (cgluc), and oxygen (coxy),respectively.Buchwald ... only try to survive, oxygen consumption scales with the availabl e concentration coxyand , at sufficiently high con-centration, it plateaus at a maximum (Rmax). As before [33], to account for...