Báo cáo y học: "Inhaled aerosolised recombinant human activated protein C ameliorates endotoxin-induced lung injury in anaesthetised sheep" pptx

... 2 Research Inhaled aerosolised recombinant human activated protein C ameliorates endotoxin-induced lung injury in anaesthetised sheep Kristine Waerhaug 1 , Vsevolod V Kuzkov 1 , Vladimir N Kuklin 1 , ... difference; ALI: acute lung injury; APC: activated protein C; ARDS: acute respiratory distress syndrome; CI: cardiac index; CT: computed tomography; EVLW: ext...

Ngày tải lên: 13/08/2014, 16:20

... E-selectin expression by endothelial cells [7]. The conversion of protein C to activated protein C is impaired during sepsis, and reduced Commentary Drotrecogin alfa (recombinant human activated protein C) in severe ... increasingly focused on the interplay between inflammation, microvascular coagulation and endothelial cell injury, and this has led to the development of...

Ngày tải lên: 12/08/2014, 22:22

... lym- phocytes, increasing thymic mass and directly affecting the thymic epithelium [46-49]. It is, however, unlikely that rhGH mediates its effect by increasing antigenic load, since the induction of ... diminished and HIV-1-specific CD4 + T-cell responses remained undetectable. TREC levels remained unchanged indicating invariable thymic output or alternatively sjTREC levels may reflect incr...

Ngày tải lên: 11/08/2014, 10:23

... online http://ccforum.com/content/8/5/337 Figure 1 Protection by recombinant human erythropoietin (rhEPO) of compressive spinal cord injury in the rat. rhEPO ameliorates spinal cord injury with ... has been injured by the host specific innate stress response can probably be achieved by administering tissue protective cytokines such as rhEPO. Only properly structured clinical trial...

Ngày tải lên: 12/08/2014, 20:20

... as early immunologic effectors in hemorrhage- or endotoxemia- Key messages • In ovine oleic acid-induced lung injury, recombinant human activated protein C (rhAPC) ameliorates the increments in ... rhAPC in other models of lung injury in sheep [16-18]. The nearly 30% decrease in oxygen delivery was caused mainly by a combined decline in SaO 2 and CI with OA...

Ngày tải lên: 13/08/2014, 11:23

... of Human Cyclin T1 Markedly Increases Human Immunodeficiency Virus Type 1 (HIV-1) Production by CD4 T Lymphocytes and Myeloid Cells in Mice Transgenic for a Provirus Encoding a Monocyte-Tropic ... [7,16,17]. Since rCycT1, like mCycT1, has a tyrosine at residue 261 in place of the hCycT1 cysteine [7], which is crucial for binding to the TAR element, rCycT1 itself may not be functional...

Ngày tải lên: 12/08/2014, 23:20

... Sense Antisense 5'-CTTGCGACCTTGACCATCTTTGGA-3' 5'-GGCGTCGTGATTAGTGATGATGAACC-3' 58 1.5 467 GATA-2 Sense Antisense 5'-TATGTGCCGGCGGCTGCCCACGACTACA-3' 5'-GGCTCTTCTGGCGGCCGACAGTCTT-3' 60 ... Sense Antisense 5'-TATGTGCCGGCGGCTGCCCACGACTACA-3' 5'-GGCTCTTCTGGCGGCCGACAGTCTT-3' 60 1.5 280 SCL Sense Antisense 5'-GAAGTGCTCCCCTCTGAAAGTT-3&...

Ngày tải lên: 14/08/2014, 08:20

... decrease in pain and increase in cervical ROM,[8] with similar effect of short duration from injec- tions of local anesthetic to myofascial trigger points in the neck. [12] While rarely a definitive ... Ake Nystrom* - anystrom@unmc.edu; Glen M Ginsburg - ginsy4549@yahoo.com; Wayne Stuberg - wstuberg@unmc.edu; Stacey Dejong - SLDEJONG@ARTSCI.WUSTL.EDU * Corresponding author Abstract In...

Ngày tải lên: 10/08/2014, 10:20

... 0,05). Discussion Acute lung injury represents acute hypoxemic respiratory failure and is associated with pulmonary and non-pulmo- nary risk factors. Interestingly, direct lung injury caused by bacteria ... 0.05). Pulmonary cytokine protein expression following CpG- ODN challenge To determine whether increased mRNA expression paral- leled also increased cytokine protein levels in...

Ngày tải lên: 12/08/2014, 15:21

... directly applicable to the dynamic breathing cycle due to a shift to the right that occurs with increasing inspiratory flows and the increase in volume that may occur at the beginning of the dynamic inspirations ... Similar cytokine levels for the two ventilatory approaches suggest that the inflammatory injury was comparable. Conclusion In this porcine model of acute lung injury, &qu...

Ngày tải lên: 12/08/2014, 18:21