Báo cáo y học: "Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock - does the dose matter" pps

... Gram-negative infection, a significantly lower increase in urinary enzymes suggestive of nephrotoxicity (N-acetyl- - D-glucosaminidase and alanine aminopeptidase) was documented in the once-daily ... review: Appropriate antibiotic therapy in severe sepsis and septic shock - does the dose matter? Federico Pea 1 and Pierluigi Viale 2 1 Institute of Cli...

Ngày tải lên: 13/08/2014, 16:20

... in sepsis seems logical, promising and opens new perspectives, many questions still remain unanswered, including the timing, dura- tion, and frequency of these therapies in the clinical setting. However, ... currently in the clinical testing phase. One such system is the molecular adsorbent regener- ating system device, which employs a polysulfone high-per- meability dialy...

Ngày tải lên: 12/08/2014, 19:22

... consistent in how the variables were analyzed, statisti- cally defined cut-offs were determined from specificity and sensitivity analyses. The cut-offs were driven by variability within the patient ... end-point for monitoring DrotAA therapy and predicting 28-day mortality at the end of therapy. To allow comparison across variables, sensitivity and specificity analyses iden...

Ngày tải lên: 13/08/2014, 08:21

... mortality, although this was not statistically significant; mortality rates in the ICU and in the ward were 25% and 12% (34% in- hospital mortality) in the sepsis group, respectively, and 19% and 8% in ... because they had nonsevere sepsis on admission. From the 697 patients included in the study, 305 were admitted for severe sepsis or septic shock (se...

Ngày tải lên: 12/08/2014, 20:20

... derivative, ethyl (6R )-6 -[ N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex- 1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppres- sion of intracellular ... [13]. Review Bench-to-bedside review: Sepsis, severe sepsis and septic shock – does the nature of the infecting organism matter? Hongmei Gao, Timothy W...

Ngày tải lên: 13/08/2014, 10:20

... Firstly, there may be confusion in identifying patients who may benefit from this therapy. Secondly, all the initial trials utilized the PAC. When this technique ran into controversy [39], the therapies associated ... permeability is increased due to a disrup- tion in the barrier function, leading to capillary leak and tissue oedema. Pro-inflammatory cytokines such as interleuk...

Ngày tải lên: 13/08/2014, 19:20

... (activated) might be obtained by initiat- ing therapy earlier". Because there is also continuing uncertainty regarding the predictors of outcome in severe sepsis, the present study had two objectives: ... remains unacceptably high at 20 to 35% and because the incidence of severe sepsis is steadily increasing, the total number of deaths continues to increase [ 1-3 ]...

Ngày tải lên: 13/08/2014, 16:20

... during study therapy. In addition, the article presents data on hypotension during therapy and recovery of kidney function in the perspective of other studies of renal support in acute kidney injury. ... conference on continuous renal replacement therapy. Kidney Int 2002, 62:185 5-1 863. 3. Palevsky PM: Clinical review: timing and dose of continuous renal replacement...

Ngày tải lên: 13/08/2014, 16:21

... antimicrobial hand-washing agent may be more effective than a non-medicated soap in reducing the rates of nosocomial infection in the ICU [13]. Hand washing is clearly simple and should be routinely adopted based ... Heat and moisture exchangers reduce the incidence of VAP by minimising the development of condensate within ventilator circuits [54], they are well tolerated by m...

Ngày tải lên: 12/08/2014, 18:21

... activity In intensive care patients there is large variability in the activity of plasma cholinesterase, an enzyme that metabolizes Commentary Is succinylcholine appropriate or obsolete in the intensive ... corticosteroids, succinylcholine can contribute to rhabdomyolysis. It is likely that cardiac arrest in such cases has an even higher mortality rate than cardiac arrest in s...

Ngày tải lên: 12/08/2014, 18:21