Báo cáo y học: "Neuroimmune perspectives in sepsis" pps

... limits acetylcholine production by the vagus nerve during sepsis. Since vagus nerve stimulation requires α 7 -nicotinic acetyl- choline receptors, direct activation of this receptor using nicotinic ... these studies, inhibition of NF-κB after partial hepatectomy results in massive hepatocyte apoptosis and impairs liver function. Conversely, NF-κB activation in the liver prevents hepatic i...

Ngày tải lên: 13/08/2014, 16:20

... basic research. The potential key role of proteins that were originally believed to be exclusively involved in coagulation in the inflammatory response provides an exciting potential mechanism(s) ... augmenting or inhibiting the contribution of the clotting cascade components to inflammation would be required for determining the selection and dosing of potential new therapies. Altering th...

Ngày tải lên: 12/08/2014, 19:21

... the effect of inflammatory mediators on the brain. Investigations addressing SAD will remain difficult due to the problem of correctly identifying and quantifying this entity. The value of monitoring cerebral ... one could speculate that, in analogy to traumatic brain injury, severe brain dysfunction is necessary to disturb CO 2 reactivity. The action of inflammatory mediators on the endoth...

Ngày tải lên: 13/08/2014, 08:21

... injury? The interpretation of S-100β, a protein found predominately in astrocytes and Schwann cells, is difficult. Even when an increase in S-100β is not due to extracranial sources, includ- ing the ... PN, Shatney CH, Schein RM, Wilson MF, Sheagren JN, Hinshaw LB: Impact of encephalopathy on mor- tality in the sepsis syndrome. The Veterans Administration Systemic Sepsis Cooperative Stu...

Ngày tải lên: 13/08/2014, 11:22

... myocardial infarction were reduced. Hypotension was very instrumental in causing the adverse events. Interestingly, sepsis and infection were also clearly more common on metoprolol. Commentary Myocardial ... offset by an increase in cardiogenic shock (11 per 1,000) [7]. This was most prominent in the first day of therapy in elderly patients with tachycardia and low blood pressure, a p...

Ngày tải lên: 13/08/2014, 11:22

... and actually exacerbate liver injury [9]. In addition to apoptosis, certain caspases, such as caspase-1, are involved in cytokine maturation by proteolytically proces- sing the inactive precursors of interleukin ... Neverthe- less, these promising findings must be tempered by the new study showing that multiple pathways might be activated in dying cells during sepsis [1]. The simple inh...

Ngày tải lên: 13/08/2014, 18:22

... brain function in sepsis. Sepsis and the brain In sepsis, the brain may be aff ected by many systemic disturbances, such as hypotension, hypoxemia, hyper- glycemia, hypoglycemia, and organ dysfunction ... brain and regulates brain capillary blood fl ow [1]. In sepsis, cerebral endothelial cells are activated by lipopoly- saccharide (LPS) and pro -in ammatory cytokines, including bradyk...

Ngày tải lên: 13/08/2014, 20:21

... erences in terms of the number of circulating NK cells, CD4 + T lymphocytes, CD8 + T lymphocytes, and B lymphocytes was limited to community-acquired pneu- monia and intra-abdominal infection. ... ammatory responses in the early phase of severe sepsis: longitudinal study of mononuclear histocompatibility leukocyte antigen-DR expression, procalcitonin, C-reactive protein, and change...

Ngày tải lên: 13/08/2014, 20:22

... models in inhibiting airway eosinophilia and airway hyperresponsiveness. 37 Recombinant IL-12 was administered subcu- taneously in increasing doses (0.1, 0.25, and 0.5 ␮g/kg) weekly in 19 individuals ... widely prescribed. Modifications to sympathomimetics resulted in increasingly long-acting increasingly selective ␤ 2 agonists, the most widely prescribed of which was salbutamol, intr...

Ngày tải lên: 08/08/2014, 20:23

... Carney RM, et al. Pathways linking depression, adiposity, and inflammatory markers in healthy young adults. Brain Behav Immun 2003;17:276–85. 125. Yao JK, Reddy RD. Metabolic investigation in psychiatric disorders. ... F 2 have a variety of effects on airway physiology, including polarizing immune cells to a Th2 phenotype, attracting immune cells, stimulating proinflammatory cytokines, in...

Ngày tải lên: 08/08/2014, 21:20