Báo cáo y học: "A tumor cord model for Doxorubicin delivery and dose optimization in solid tumors Steffen Eikenberry" ppsx

... significant interest in modeling fluid flow and delivery of macromol- ecules within solid tumors [8-11]. Some modeling work has considered spatially explicit drug delivery to solid tumors [12-14], ... DOX. Interestingly, binding to proteins affects DOX delivery dif- ferently in the plasma and extracellular tumor space. While increasing the fraction of bound DOX in th...

Ngày tải lên: 13/08/2014, 16:20

... 6:120-126. 7. Uchiyama Y, Yorozu K, Hashizume M, Moriya Y, Mihara M: Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis. ... validity in safety and toxicity tests. Disparities between humans and marmosets in the immune system will decrease the cross-reactivity of human-specifi c therapeutic...

Ngày tải lên: 12/08/2014, 15:22

... and AUC for the testing set are very close to the training set esti- mates, indicating that the Bayes linear model designed from training set maintains very similar discrimination performance with ... developed a Bayes linear model to discriminate morbidity risk after coronary artery bypass grafting and compared it with three different score models: the Higgins' original scorin...

Ngày tải lên: 12/08/2014, 23:24

... assumptions examining shorter vac- cine efficacy durations and including the need for a repeat dose or possible waning in vaccine efficacy were considered in the sensitivity analysis. A vaccine coverage ... analysis (PSA) was also performed and several parameters were included. In particular, HZ vaccine efficacy was tested by varying the base efficacy using a beta distribution...

Ngày tải lên: 13/08/2014, 11:22

... isolated in community-acquired pneumonia is increasingly found in primary pyogenic liver abscesses. The presence of magA in K. pneumoniae has been impli- cated in hypermucoviscosity and virulence ... ampicillin and intermediate to ampicillin/sulbactam. It was sensitive to the cephalosporins (cefazolin, cefotaxime, and cefepime), the fluoroquinolones (ciprofloxacin, levofloxa...

Ngày tải lên: 26/10/2012, 09:53

... leaving Boston seventeen twenty one ar- riving Fort Worth twenty two twenty one forty Here, 'twenty two twenty one forty' must be interpreted as a flight arrival time; the system ... early detection of repairs in recognition, permitting early pruning of the hypothesis space. One proposal for repair processing that lends it- self to both incremental processing and the...

Ngày tải lên: 20/02/2014, 21:20

... deaths were caused by DM, 17 by myocardial infarction, and 12 by chronic ischemic heart diseases Table 1. The corresponding SMR were 6.4 for DM (95% CI:3.5-10.8), 2.3 for myocardial infarction (95% ... have used mortality rates in the general population as a bench mark for com- parison, because the overall mortality of HIV-infected individuals is increasingly influenced by deaths th...

Ngày tải lên: 10/08/2014, 05:21

... Concluding Remarks In summary, we have refined the RTA model developed in [6] by incorporating diffusion of reacting species in the extracell ular space. By solving numerically the system of non- linear ... number of ways of refining the simple kinetic model for the Receptor- Toxin-Antibody (RTA) system proposed in [6]. The possibilities include incorporating a mechanism of rece...

Ngày tải lên: 13/08/2014, 16:20

... by maintaining a stationary cell density distribution that peaks well before the Hayflick limit. The healing rates of damaged endothelia for young, middle-aged, and old persons are compared and ... reality, the healing process is very complex involving many other types of cells, including platelet cells that aggregate on the wound during the clotting cascade. Recent work [5] has shown t...

Ngày tải lên: 13/08/2014, 16:21

... Thierry Colin 2 and Santiago Schnell 3 Address: 1 Institute for Theoretical Medicine and Clinical Pharmacology Department, Faculty of Medicine R.T.H Laennec, University of Lyon, Paradin St., ... factors such as hypoxia, as well as tumor geometry and tissue dynamics, in predicting and improving radiotherapeutic efficacy. Conclusion: This model provides insight into the coupl...

Ngày tải lên: 13/08/2014, 23:20